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Phylloquinone (vitamin K1) intakes and serum undercarboxylated osteocalcin levels in Irish postmenopausal women

Published online by Cambridge University Press:  08 March 2007

Aoife Collins ,
Kevin D. Cashman  and
Máiréad Kiely
Aoife Collins*
Affiliation:
Department of Food and Nutritional Sciences, University College, Cork, Ireland
Kevin D. Cashman
Affiliation:
Department of Food and Nutritional Sciences, University College, Cork, Ireland Department of Medicine, University College, Cork, Ireland
Máiréad Kiely
Affiliation:
Department of Food and Nutritional Sciences, University College, Cork, Ireland
*
*Corresponding author: Dr Aoife Collins, fax +353 21 4270244, email collinsaoife@ucc.ie
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Abstract

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Low phylloquinone (vitamin K1) intakes have been associated with low bone mineral density in older adults. Phylloquinone intakes and serum undercarboxylated osteocalcin (ucOC) levels were assessed in ninety-seven apparently healthy, free-living Irish women aged 50–75 years. Phylloquinone intakes were estimated using a detailed dietary history, which measured habitual food intakes from a typical 14 d period, and recently published food composition data for phylloquinone. Fasting serum ucOC was measured using an enzyme immunoassay. The median daily intake of phylloquinone in the group from all sources was 108·8 mg and from food sources only was 106·6 mg, indicating that approximately 99% of the phylloquinone came from food. Vegetables and vegetable dishes contributed 67% of the total phylloquinone intake, but further analysis showed that broccoli, cabbage and lettuce were the primary sources, making a total contribution of 44 %. Twenty per cent of the women had a phylloquinone intake below the UK recommendation of 1μg/kg body weight per day and 34% failed to meet the US Adequate Intake value of 90mg/day. Mean serum ucOC levels in the women were 6·2 (SD 1·7) ng/ml and were predicted by phylloquinone intake (β— 22·20, generated from log-transformed phylloquinone intake data; P=4 0·04). On the basis of comparisons with both UK recommendations and US A equate Intakes for phylloquinone, the habitual intakes of phylloquinone in a high proportion of Irish postmenopausal women may not be adequate.

Keywords

Phylloquinone intakeUndercarboxylated osteocalcinBone health
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 5 , May 2006 , pp. 982 - 988
Copyright
Copyright © The Nutrition Society 2006

References

Askim, M, Vitamin K in the Norwegian diet and osteoporosis. Tids Den Norske Laege 2001 121 2614–2616.Google ScholarPubMed
Binkley, NC, Krueger, DC, Engelke, JA, Foley, AL, Suttie, JW, Vitamin, K, supplementation reduces serum concentrations of under-γ-carboxylated osteocalcin in healthy young and elderly adults. Am J Clin Nutr 2000 72 1523–1528.CrossRefGoogle Scholar
Binkley, NC, Suttie, JW, Vitamin K nutrition and osteoporosis. J Nutr 1995 125 1812–1821.CrossRefGoogle ScholarPubMed
Bolton-Smith, C, Price, RJG, Fenton, ST, Harrington, DJ, Shearer, MJ, Compilation of provisional UK database for the phylloquinone (vitamin K1) content of foods. Br J Nutr 2000 83 389–399.Google ScholarPubMed
Booth, SL, Broe, KE, Gagnon, DR, et al.. Vitamin K intake and bone mineral density in women and men. Clin Endocrinol Metab 2003 89 4904–4909.CrossRefGoogle Scholar
Booth, SL, Sadowski, JA, Pennington, JAT, Phylloquinone (vitamin K1) content of foods in the U.S. Food and Drug Administration'sTotal Diet Study. J Agric Food Chem 1995 43 1574–1579.Google Scholar
Booth, SL, Tucker, KL, Chen, H, et al. Dietary vitamin K intakes are associated with hip fracture but not with bone mineral density in elderly men and women. Am J Clin Nutr 2000 71 1201–1208.CrossRefGoogle Scholar
Carriquiry, AL, Assessing the prevalence of nutrient inadequacy. Public Health Nutr 1999 2 23–33.CrossRefGoogle ScholarPubMed
Conway, SP, Wolfe, SP, Brownlee, KG, White, H, Oldroyd, B, Truscott, JG, Harvey, JM, Shearer, MJ, Vitamin K status among children with cystic fibrosis and its relationship to bone mineral density and bone turnover. Pediatrics 2005 115 1325–1331.Google Scholar
Department of Health Dietary Reference Values for Food Energy and Nutrients for the United Kingdom Report on Health and Social Subjects No. 41. LondonHMSO 1991Google Scholar
Duggan, p, Cashman, kd, Flynn, a, Bolton-Smith, c, Kiely, m, Phylloquinone (vitamin K1) intakes and food sources in 18–64 year old Irish adults. Br J Nutr 2004 92 151–158.Google Scholar
Fenton, ST, Price, RJ, Bolton-Smith, C, Harrington, D, Shearer, MJ, Nutrient sources of phylloquinone (vitamin K1) in Scottish men and women. Proc Nutr Soc 1997 56 301A.Google Scholar
Feskanich, D, Weber, P, Willett, WC, Rockett, H, Booth, SL, Colditz, GA, Vitamin K intake and hip fracture in women: a prospective study. Am J Clin Nutr 1999 69 74–79.Google Scholar
Finch, S, Doyle, W, Lowe, C, Bates, CJ, Prentice, A, Smithers, G, Clarke, PC, National Diet and Nutrition Survey: People Aged 65 Years and Over Report of the Diet and Nutrition Survey 1 LondonStationery Office. 1998Google Scholar
French, MR, Langdon, C, Levy-Milne, R, Development of a validated food frequency questionnaire to determine folate intake. Can J Diet Prac Res 2001 62 82–86.Google Scholar
Gundberg, CM, Nieman, SD, Abrams, S, Rosen, H, Vitamin, K, status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 1998 83 3258–3266.Google Scholar
Harrington, KE, Robson, PJ, Kiely, M, Livingstone, MBE, Lambe, J, Gibney, MJ, The North/South Ireland Food Consumption Survey: survey design and methodology. Public Health Nutr 2001 4 1037–1042.Google Scholar
Herbert, JR, Hurley, TG, Chiriboga, DE, Barone, J, A comparison of selected nutrient intakes derived from three diet assessment methods used in a low-fat maintenance trial. Public Health Nutr 1998 1 207–214.CrossRefGoogle Scholar
Holland, B, Welch, AA, Unwin, ID, Buss, DH, Paul, AA, Southgate, DAT, (1995) McCance & Widdowson's The Composition of Foods, 5th edn. Royal Society of Chemistry/Ministry of Agriculture, Fisheries and Food. London: HMSOGoogle Scholar
Institute of Medicine Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc. Washington, DC: National Academy Press. 2001Google Scholar
Jie, K-SG, Bots, ML, Vermeer, C, Witteman, JCM, Grobbee, DE, Vitamin K intake and osteocalcin levels in women with and without aortic atherosclerosis: a population-based study. Atherosclerosis 1995 116 117–123.CrossRefGoogle ScholarPubMed
Jie, K-SG, Bots, ML, Vermeer, C, Witteman, JCM, Grobbee, DE, Vitamin K status and bone mass in women with and without atherosclerosis: a population-based study. Calcif Tissue Int 1996 59 352–356.CrossRefGoogle ScholarPubMed
Knapen, MHJ, Hamulyák, K, Vermeer, C, The effect of vitamin K supplementation on circulating osteocalcin (bone Gla protein)and urinary calcium excretion. Ann Intern Med 1989 111 1001–1005.Google Scholar
Kohlmeier, M, Salomon, A, Saupe, J, Shearer, MJ, Transport of vitamin K to bone in humans. J Nutr 1996 126 S1192–S1196.CrossRefGoogle ScholarPubMed
Lahmann, PH, Kumanyika, SK, Attitudes about health and nutrition are more indicative of dietary quality in 50- to 75-yearold women than weight and appearance concerns. J Am Diet Assoc 1999 4 475–478.CrossRefGoogle Scholar
McKeown, NM, Jacques, PF, Gundberg, CM, Peterson, JW, Tucker, KL, Kiel, DP, Wilson, PW, Booth, SL, Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J Nutr 2002 132 1329–1334.CrossRefGoogle ScholarPubMed
Ministry of Agriculture, Fisheries and Food Food Portion Sizes. London: Stationery Office. 1997Google Scholar
National Research Council Recommended Dietary Allowances.10th ed. Washington, D.C: National Academy Press. 1989Google Scholar
O'Brien, M, Flynn, A, Kiely, M, Vegetable intake in the Irish population. Public Health Nutr 2003 6 711–726.Google Scholar
Plantalech, L, Chapuy, MC, Guillaumont, M, Chapuy, P, Leclerq, M, Delmas, DP, Christiansen, C, Overgaard, K, Copenhagen: Osteopress. 1990.Google Scholar
Price, PA, Role of vitamin K dependent proteins in bone metabolism. Ann Rev Nutr 1988 8 565–583.CrossRefGoogle ScholarPubMed
Price, R, Fenton, S, Shearer, MJ, Bolton-Smith, C, Daily and seasonal variation in phylloquinone (vitamin K1) intake in Scotland. Proc Nutr Soc 1996 55 244A.Google Scholar
Rambeck, WA, Stahelin, HB, Emerging scientific evidence. Vitamin K and bone metabolism: effects of vitamins on behaviour and cognition. Biblio Nutr Diet 2001 55 206–208.Google Scholar
Schurgers, LJ, Geleijnse, JM, Grobbee, DE, Pols, HAP, Hofman, A, Witteman, JCM, Vermeer, C, Nutritional intake of vitamins K1 (phylloquinone) and K2 (menaquinone) in the Netherlands. J Nutr Environ Med 1999 9 115–122.Google Scholar
Shearer, MJ, Vitamin K and vitamin K dependent proteins. Br J Haem 1990 75 156–162.Google ScholarPubMed
Shearer, MJ, Role of vitamin K and Gla proteins in the pathophysiology of osteoporosis and vascular calcification. Curr Opin Clin Nutr Metab Care 2000 3 433–438.CrossRefGoogle ScholarPubMed
Shearer, MJ, Bach, A, Kohlmeier, M, Chemistry, nutritional sources, tissue distribution and metabolism of vitamin K with special reference to bone health. J Nutr 1996 126 1181S–1186S.Google Scholar
Sokoll, LJ, Booth, SL, O'Brien, ME, Davidson, KW, Tsaioun, KI, Sadowski, JA, Changes in serum osteocalcin, plasma phylloquinone and urinary γ-carboxyglutamic acid in response to altered intakes of dietary phylloquinone in human subjects. Am J Clin Nutr 1997 65 779–784.CrossRefGoogle ScholarPubMed
Sokoll, lj, Sadowski, ja, Comparison of biochemical indexes for assessing vitamin K status in a healthy adult population. Am J Clin Nutr 1996 63 566–573.CrossRefGoogle Scholar
Szulc, p, Arlot, M, Chapuy, MC, Duboeuf, F, Muenier, PJ, Delmas, PD, Serum undercarboxylated osteocalcin correlates with hip bone mineral density in elderly women. J Bone Miner Res 1994 9 1591–1595.Google Scholar
Szulc, P, Chapuy, MC, Meunier, PJ, Delmas, PD, Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture in elderly women. J Clin Invest 1993 91 1769–1774.Google Scholar
Szulc, P, Chapuy, MC, Meunier, PJ, Delmas, PD, Serum undercarboxylated osteocalcin is a marker of the risk of hip fracture: a three year follow-up study. Bone 1996 18 487–488.CrossRefGoogle ScholarPubMed
Tapsell, LC, Brenninger, V, Barnard, J, Applying conversation analysis to foster accurate reporting in the diet history interview. J Am Diet Assoc 2000 100 818–824.CrossRefGoogle ScholarPubMed
Thane, CW, Paul, AA, Bates, CJ, Bolton-Smith, C, Prentice, A, Shearer, MJ, Intake and sources of phylloquinone (vitamin K1) variation with socio-demographic and lifestyle factors in a national sample of British elderly people. Br J Nutr 2002 87 605–613.Google Scholar
Vergnaud, P, Garnero, P, Meunier, PJ, Breart, G, Kamihagi, K, Delmas, PD, Undercarboxylated osteocalcin measured with a specific immunoassay predicts hip fracture in elderly women: the EPIDOS Study. J Clin Endocrinol Metab 1997 82 719–724.Google Scholar
Vermeer, C, Gijsbers, BLMG, Craciun, AM, Groenen-Van Dooren, MMCL, Knapen, MHJ, Effects of vitamin K on bone mass and bone metabolism. J Nutr 1996 126 S1187–S1191.Google Scholar
Vermeer, C, Jie, KSG, Knapen, MHJ, Role of vitamin K in bone metabolism. Annu Rev Nutr 1995 15 1–22.Google Scholar
Weber, P, Vitamin K and bone health. Nutrition 2001 17 880–887.CrossRefGoogle ScholarPubMed
Yan, L, Zhou, B, Greenberg, D, Wang, L, Nigdikar, S, Prynne, C, Prentice, A, Vitamin K status of older individuals in the UK. Br J Nutr 2004 92 939–945.CrossRefGoogle ScholarPubMed