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The initial physiological responses to glucose ingestion in normal subjects are modified by a 3 d high-fat diet

Published online by Cambridge University Press:  09 March 2007

M. B. Sidery ,
I. W. Gallen  and
I. A. Macdonald
M. B. Sidery
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH
I. W. Gallen
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH
I. A. Macdonald
Affiliation:
Department of Physiology and Pharmacology, University of Nottingham Medical School, Clifton Boulevard, Nottingham NG7 2UH
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Abstract

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The present study was designed to investigate whether 3 d of high-fat, low-carbohydrate diet (with normal daily energy intake) affected the metabolic, cardiovascular and thermic responses to an oral glucose load (1.5 g/kg body-weight). Eight normal weight, healthy subjects (five male) consumed diets containing approximately 65 % by energy of carbohydrate (C) or fat (F), each for 3 d. Before and after glucose ingestion, continuous recordings of oxygen consumption and carbon dioxide production were made using indirect calorimetry, and metabolic rate (MR) and respiratory exchange ratio (RER) were calculated. Heart rate, blood pressure and limb blood flow were also measured. There was no significant change in baseline MR following the high-fat diet, but the fasting RER was reduced. The high-fat diet modified the responses to oral glucose, with a greater increase in MR (kJ/min; C + 0.38, F + 0.76), and an enhanced plasma insulin response (mU/l; C + 51.5, F + 85.0). There were no differences between the two diets with respect to the baseline blood glucose levels or the changes after glucose ingestion. Heart rate, systolic and diastolic blood pressures and blood flow responses to the glucose load were similar after the two diets. There was no plasma catecholamine response to glucose ingestion. It can be concluded that a high-fat diet alters the initial thermic response and insulin response but does not alter the other physiological responses to glucose ingestion.

Keywords

Glucose toleranceFat intakeInsulin
Type
Diet and Metabolic Response to Glucose
Information
British Journal of Nutrition , Volume 64 , Issue 3 , November 1990 , pp. 705 - 713
Copyright
Copyright © The Nutrition Society 1990

References

Acheson, K. J., Jequier, E. & Wahren, J. (1983). The influence of β-adrenoceptor blockade on glucose induced thermogenesis in man. Journal of Clinical Investigation 72, 981–986.CrossRefGoogle Scholar
Acheson, K. J., Ravussin, E., Wahren, J. & Jequier, E. (1984). The thermic effect of glucose in man. Journal of Clinical Investigation 74, 1572–1580.CrossRefGoogle ScholarPubMed
Alban-Davies, H. J., Baird, I., Fowler, J., Mills, I. H., Baille, J. E., Ratten, S. & Howard, A. N. (1989). Metabolic responses to low- and very-low-calorie diets. American Journal of Clinical Nutrition 49, 745–751.Google Scholar
Andres, R., Zierler, K. I., Anderson, H. M., Stainsby, W. N., Cader, G., Ghrayyib, A. & Lilienthal, J. L. (1954). Measurement of blood flow in human limbs; detailed notes on the theory of indicator-dilution and intravascular injection. Journal of Clinical Investigation 33, 482–504.CrossRefGoogle Scholar
Elia, M. & Livesey, G., (1988). Theory and validity of indirect calorimetry during net lipid synthesis. American Journal of Clinical Nutrition 47, 591–604.CrossRefGoogle ScholarPubMed
Fagan, T., Sawyer, P. R., Gourley, L. A., Lee, J. T. & Gaffney, T. E. (1986). Postprandial alteration in haemodynamics and blood pressure in normal subjects. American Journal of Cardiology 58, 636–641.Google Scholar
Fellows, I. W. & Macdonald, I. A. (1985). An automated method for the measurement of oxygen consumption and carbon dioxide excretion in man. Clinical Physics and Physiological Measurement 6, 349–355.Google Scholar
Flatt, J. P. (1978). The biochemistry of energy expenditure. In Recent Advances in Obesity, vol. 2, pp. 211–218 [Bray, G. A., editor]. London: Newman.Google Scholar
Gallen, I. W. & Macdonald, I. A. (1990). The effect of 48 h fast on the physiological responses to food ingestion in normal-weight women. British Journal of Nutrition 63, 53–64.CrossRefGoogle ScholarPubMed
Lloyd, B., Burrin, J., Smythe, P. & Alberti, K. G. M. M. (1978). Enzymic fluorimetric continuous flow assays for blood glucose, lactate, pyruvate, alanine, glycerol and 3-hydroxybutyrate. Clinical Chemistry 24, 1724–1729.CrossRefGoogle Scholar
Lusk, G. (1924). Animal calorimetry. Analysis of the oxidation of mixtures of carbohydrate and fat. Journal of Biological Chemistry 59, 41–42.Google Scholar
Macdonald, I. A. & Lake, D. M. (1985). An improved technique for extracting catecholamines from body fluids. Journal of Neuroscience Methods 13, 239–248.Google Scholar
McGuire, E. A. H., Helderman, J. H., Tobin, J. D., Andres, R. & Berman, M. (1976). Effects of arterial versus venous sampling on analysis of glucose kinetics in man. Journal of Applied Physiology 41, 565–573.CrossRefGoogle ScholarPubMed
Randle, P. J., Garland, P. B., Hales, C. N. & Newshotme, E. A. (1963). The glucose fatty-acid cycle: its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i, 785–789.Google Scholar
Thiebaud, D., DeFronzo, R. A., Jacot, E., Golay, A., Acheson, K., Maeder, E., Jequier, E. & Felber, J.-P. (1982). Effect of long-chain triglyceride infusion on glucose metabolism in man. Metabolism 31, 1128–1136.CrossRefGoogle ScholarPubMed
Thulin, L. & Samnegard, H. (1978). Circulatory effects of gastrointestinal hormones and related peptides. Acta Chirurgica Scandinavica 144, Suppl 482, 73–74.Google Scholar
Webb, P. (1986). 24-hour energy expenditure and the menstrual cycle. American Journal of Clinical Nutrition 44, 614–619.Google Scholar
Weir, J. B. de V (1949). New methods for calculating metabolic rate with special reference to protein metabolism. Journal of Physiology 109, 1–9.CrossRefGoogle ScholarPubMed
Welle, S. L., Lilavivathana, U. & Campbell, R. G. (1980). Increased plasma norepinephrine concentrations and metabolic rate following glucose ingestion in man. Metabolism 29, 806–809.Google Scholar
Whitney, R. J. (1953). Measurement of volume changes in human limbs. Journal of Physiology 121, 1–27.CrossRefGoogle ScholarPubMed