Hostname: page-component-cd9895bd7-lnqnp Total loading time: 0 Render date: 2024-12-26T11:37:37.289Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of undernutrition in the early postnatal period on skeletal muscle tissue

Published online by Cambridge University Press:  09 March 2007

Stephanie S. Ward  and
Neil C. Stickland
Stephanie S. Ward
Affiliation:
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NWI OTU
Neil C. Stickland
Affiliation:
Department of Veterinary Basic Sciences, The Royal Veterinary College, Royal College Street, London NWI OTU
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Guinea-pigs were undernourished from birth by first, cross-fostering in groups of six (in pairs for control animals) and then by feeding a diet of 60% of ad lib. intake from 2 to 6 weeks. The changing characteristics of muscle fibre types in the biceps brachii and soleus muscles were monitored by histochemistry. Undernutrition appeared to delay maturation of muscle fibres. Fibre cross-sectioned area was reduced in all fibres of the 60% of ad lib. intake group. Fibres of the biceps brachii were more affected than those of the soleus. Fibre area vulnerability was partly associated with a high relative growth rate in biceps brachii at this time. Total protein content in the semitendinosus muscle was depressed in the undernourished group compared with the control group. DNA concentrations were initially higher in the control group but decreased in both groups to similar levels by 6 weeks. RNA concentration increased up to 5 weeks in the control group and then decreased, but decreased after 2 weeks in the undernourished group.

Keywords

MuscleUndernutritionDifferentiation
Type
Effects of Undernutrition on Growth
Information
British Journal of Nutrition , Volume 69 , Issue 1 , January 1993 , pp. 141 - 150
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Ashmore, C. R., Addis, P. B. & Doerr, L. (1972). Postnatal development of muscle fibre types in domestic animals. Journal of Animal Science 34, 37–41.CrossRefGoogle ScholarPubMed
Aziz-Ullah, (1974). Studies on muscle development with specific reference to the effects of protein malnutrition. PhD Thesis, University of Hull.Google Scholar
Baldwin, K. M. (1984). Muscle development; neonatal to adult. Exercise and Sport Sciences Reviews 12, 1–19.CrossRefGoogle ScholarPubMed
Baldwin, K. M., Cambell, P. J., Hooker, A. M. & Lewis, R. E. (1978). Enzyme changes in neonatal skeletal muscle; effect of thyroid deficiency. American Journal of Physiology 235, 97–102.CrossRefGoogle ScholarPubMed
Barany, M. (1967). ATPase activity of myosin correlated with speed of shortening. Journal of General Physiology 50, 197–218.CrossRefGoogle Scholar
Bedi, K. S., Birzgalis, A. R., Mahon, M., Smart, J. L. & Wareham, A. C. (1982). Early life undernutrition in rats; I. Quantitative histology of skeletal muscles from underfed young and adult refed animals. British Journal of Nutrition 47, 417–431.CrossRefGoogle Scholar
Butler-Browne, G. S. & Whalen, R. G. (1984). Myosin isozyme transitions occurring during the postnatal development of the rat soleus muscle. Developmental Biology 102, 324–334.CrossRefGoogle ScholarPubMed
Close, R. (1964). Dynamic properties of fast and slow muscles of the rat during development. Journal of Physiology 173, 74–95.CrossRefGoogle ScholarPubMed
Drachman, P. B. & Johnson, D. M. (1973). Development of a mammalian fast muscle; dynamic and biochemical properties related. Journal of Physiology 234, 29–43.CrossRefGoogle Scholar
Dubowitz, V. & Pearce, A. G. E. (1960). Reciprocal relation of phosphorylase and oxidative enzymes in skeletal muscle. Nature 185, 701–702.CrossRefGoogle Scholar
Engel, W. K. & Kaparti, G. (1968). Impaired skeletal muscle maturation following neonatal neurectomy. Developmental Biology 17, 713–723.CrossRefGoogle ScholarPubMed
Gauthier, G. F., Lowey, S., Benfield, P. A. & Hobbs, A. W. (1982). Distribution and properties of myosin isozymes in developing avian and mammalian skeletal muscle fibres. Journal of Cell Biology 92, 47–84.Google Scholar
Gauthier, G. F., Lowey, S. & Hobbs, A. W. (1978). Fast and slow myosin in developing muscle fibres. Nature 274, 25–29.CrossRefGoogle ScholarPubMed
Goldspink, G. (1962). Biochemical and physiological changes associated with the postnatal development of the biceps brachii. Comparative Biochemisfry and Physiology 7, 157–168.CrossRefGoogle ScholarPubMed
Goldspink, G. & Howells, K. F. (1974). Work induced hypertrophy in exercised normal muscles of different ages and the reversibility of hypertrophy after the cessation of exercise. Journal of Physiology 239, 179–193.CrossRefGoogle ScholarPubMed
Goldspink, G. & Ward, P. S. (1979). Changes in rodent muscle fibre types during postnatal growth, nutrition and exercise. Journal of Physiology 296, 453469.CrossRefGoogle Scholar
Guth, L. & Samaha, F. J. (1970). Research note: Procedure for the histochemical demonstration of Actomyosin ATPase. Experimental Neurology 28, 365–367.CrossRefGoogle Scholar
Helander, E. (1957). On quantitative muscle protein determination. Sarcoplasm and myofibril protein content of normal and atrophic skeletal muscles. Acta Physiologica Scandinavica 41, Suppl., 141.Google ScholarPubMed
Hoh, J. F., Hughes, S., Hugh, G. & Pozagaj, I. (1988). Three hierarchies in skeletal muscle fibre classification: allotype, isotype and phenotype. UCLA Symposia on Molecular and Cellular Biology Suppl., 12C.Google Scholar
Howells, K. F., Matthews, D. R. & Jordan, T. C. (1978). Effects of pre and perinatal malnutrition on muscle fibres from fast and slow rat muscles. Research into Experimental Medicine 173, 35–40.CrossRefGoogle ScholarPubMed
Ianuzzo, C. P., Patel, P., Chen, V. & O'Brien, P. (1980). A possible thyroidal trophic influence on fast and slow skeletal myosin. In Plasticity of Muscle, pp. 593–606 [Pette, D., editor]. Berlin: de Gruyter.Google Scholar
Lyons, S. E., Kelly, A. M., Rubenstein, N. A. & Hazelgrove, J. (1983). Myosin transitions in developing fast and slow muscles of the rat hind limb. Differentiation 25, 163–175.Google Scholar
Millward, D. J. (1970). Protein turnover in skeletal muscle. I. The measurement of rates of synthesis and catabolism of skeletal muscle protein using (14C) Na2CO3, to label protein. Clinical Sciences 39, 577–590.Google ScholarPubMed
Moss, F. P. & Leblond, C. P. (1971). Satellite cells as the source of nuclei in the muscle of growing rats. Anatomical Record 170, 421–430.CrossRefGoogle ScholarPubMed
Munro, H. N. & Fleck, A. (1966). The determination of nucleic acids. Methods of Biochemical Analysis 14, 133–176.Google ScholarPubMed
Nachlas, M. M., Tsouk, K., De Sousa, F., Cheng, C. & Seligman, M. (1957). Cytochemical demonstration of succinic dehydrogenase by the use of a new p-nitrophenol substituted ditetrazole. Journal of Histochemistry and Cytochemistry 5, 420–436.CrossRefGoogle Scholar
Noble, E. G., Dabrowski, B. L. & Ianuzzo, C. P. (1983). Myosin transformation in hypertrophied rat muscle. Pflügers Archives 396, 260–271.CrossRefGoogle ScholarPubMed
Peter, J. B., Barnard, R. J., Edgerton, V. R., Gillespie, C. A. & Stempel, K. E. (1972). Metabolic profiles of 3 fibre types of skeletal muscle in guinea-pigs and rabbits. Biochemistry 11, 2627–2633.CrossRefGoogle Scholar
Prior, R. C., Scott, R. A., Lister, D. B. & Campion, D. R. (1979). Maternal energy status and development of liver and muscle in the bovine foetus. Journal of Animal Science 48, 15341545.CrossRefGoogle Scholar
Sillau, A. H. & Banchero, N. (1977). Effect of malnutrition on capillary density, fibre size and composition in rat skeletal muscle. Proceedings of the Society of Experimental and Biological Medicine 154, 461 466.CrossRefGoogle Scholar
Stickland, N. C., Widdowson, E. M. & Goldspink, G. (1975). Effects of severe energy and protein deficiencies on the fibres and nuclei of skeletal muscle of pigs. British Journal of Nutrition 34, 421–428.CrossRefGoogle ScholarPubMed
Swatland, H. J. (1983). Aerobic activity in the axis of the growing myofibres in the porcine biceps femoris. Journal of Anima1 Science 56, 13241328.Google Scholar
Takeuchi, T. (1956). Histochemical demonstration of phosphorylase. Journal of Histochemistry and Cytochemistry 4, 84.CrossRefGoogle Scholar
Ward, S. S. (1989). The effect of undernutrition on skeletal muscle development and growth in the guinea pig. PhD Thesis, University of London.Google Scholar
Wigmore, P. M. C. (1982). Prenatal muscle development in the pig. PhD Thesis, University of Edinburgh.Google Scholar
Winick, M. & Nobel, A. (1966). Cellular response in rats during malnutrition at various ages. Journal of Nutrition 89, 300–306.CrossRefGoogle ScholarPubMed