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Effect of postprandial lipaemia and Taq 1B polymorphism of the cholesteryl ester transfer protein (CETP) gene on CETP mass, activity, associated lipoproteins and plasma lipids

Published online by Cambridge University Press:  09 March 2007

Enda Noone ,
Helen M. Roche ,
Irene Black ,
Anne-Marie Tully  and
Michael J. Gibney
Enda Noone*
Affiliation:
Unit of Nutrition, The Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin 8, Republic of Ireland
Helen M. Roche
Affiliation:
Unit of Nutrition, The Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin 8, Republic of Ireland
Irene Black
Affiliation:
Unit of Nutrition, The Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin 8, Republic of Ireland
Anne-Marie Tully
Affiliation:
Unit of Nutrition, The Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin 8, Republic of Ireland
Michael J. Gibney
Affiliation:
Unit of Nutrition, The Trinity Centre for Health Sciences, St James's Hospital, James's St, Dublin 8, Republic of Ireland
*
*Corresponding author: Dr Enda Noone, fax +353 1 4542043, email enoone@tcd.ie
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Abstract

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A large number of studies in recent years have investigated the effects of hyperlipidaemias and diabetes on cholesteryl ester transfer protein (CETP) on neutral lipid transfer activity and plasma lipids. There has been an ongoing debate as to whether CETP is pro- or anti-atherogenic as it provides a mechanism for the transfer of cholesterol from the cardioprotective HDL subfraction to the potentially atherogenic LDL subfraction. This study was designed to investigate whether there was significant variability of CETP mass and activity in a large normolipidaemic population and whether there is an association between CETP and plasma lipoprotein composition. The presence of a known polymorphism of CETP gene (Taq 1B) was investigated to see if there was any association between this polymorphism and CETP mass and activity, and plasma lipids. There was significant (P < 0·0001) increase in CETP mass and activity in plasma postprandially at 6 h. Using multiple stepwise regression analysis there was significant association with fasting CETP mass and activity (β = 0·055; P = 0·002) and triacylglycerol-rich lipoprotein (β = 0·013; P = 0·005) and postprandial CETP mass (β = 0·254; P = 0·007). Repeated-measures analysis showed a strong association between the absence of Taq 1B polymorphism and low CETP mass and elevated HDL- and HDL2-cholesterol and HDL-phospholipid concentrations than did those who were homozygous or heterozygous for the presence of the restriction site.

Keywords

Cholesteryl ester transfer proteinTaq 1B polymorphismPostprandial lipaemia
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 2 , August 2000 , pp. 203 - 209
Copyright
Copyright © The Nutrition Society 2000

References

Abbey, M and Nestel, PJ (1994) Plasma cholesteryl ester transfer protein activity is increased when trans-elaidic acid is substituted for cis-oleic acid in the diet. Atherosclerosis 106, 99–107.CrossRefGoogle ScholarPubMed
Bagdade, JD, Ritter, MC and Subbaiah, PV (1992) Accelerated cholesteryl ester transfer in plasma of patients with hypercholesterolemia. Journal of Clinical Investigation 87, 1259–1265.CrossRefGoogle Scholar
Bernard, S, Moulin, P, Lagrost, L, Picard, S, Elchebly, M, Ponsin, G, Chapuis, F and Berthezene, F (1998) Association between plasma high density lipoprotein cholesterol concentration and Taq 1B cholesteryl ester transfer protein gene polymorphisms in non insulin dependent diabetes mellitus. Journal of Lipid Research 39, 59–65.CrossRefGoogle Scholar
de Bruin, TWA, Brouwer, CB, van Linde-Sibenius Trip, M, Jansen, H and Erkelens, DW (1993) Different postprandial metabolism of olive oil and soya bean oil: a possible mechanism of high density lipoprotein conserving effect of olive oil. American Journal of Clinical Nutrition 58, 477–483.CrossRefGoogle ScholarPubMed
Castro, GR and Fielding, CJ (1985) Effect of postprandial lipaemia on plasma cholesterol metabolism. Journal of Clinical Investigation 75, 874–882.CrossRefGoogle ScholarPubMed
Clarke, RW, Moberly, JB and Bamberger, MJ (1995) Low level quantification of cholesteryl ester transfer protein in plasma subfractions and cell culture media by monoclonal antibody based immunoassay. Journal of Lipid Research 36, 876–889.CrossRefGoogle Scholar
Freeman, DJ, Griffin, BA, Holmes, P, Lindsay, GM, Gaffney, D, Packard, CJ and Shepard, J (1993) Regulation of plasma HDL cholesterol and subfraction distribution by genetic and environmental factors. Associations between the Taq 1B RFLP in the CETP gene and smoking and obesity. Arteriosclerosis and Thrombosis 14, 336–344.CrossRefGoogle Scholar
Freeman, DJ, Packard, CJ, Shepard, J and Gaffney, D (1990) Polymorphisms in the gene coding for cholesteryl ester transfer protein are related to plasma high density lipoprotein cholesterol and transfer activity. Clinical Science 79, 575–581.CrossRefGoogle Scholar
Fielding, CJ and Fielding, PE (1995) Molecular physiology of reverse cholesterol transport. Journal of Lipid Research 36, 211–228.CrossRefGoogle ScholarPubMed
Groener, JE, van Ramhorst, EM, Katan, MB, Mensink, RP and van Tol, A (1991) Diet induced alteration in the activity of plasma lipid transfer protein in normolipidemic human subjects. Atherosclerosis 87, 221–226.CrossRefGoogle ScholarPubMed
Groener, JEM, Pelton, RW and Kostner, GM (1986) Improved estimation of cholesteryl ester transfer/exchange activity in serum or plasma. Clinical Chemistry 32, 283–286.CrossRefGoogle ScholarPubMed
Guyard-Dangremont, V, Lagrost, L and Gambert, P (1994) Comparative effects of purified apolipoproteins A-1, A-II, and A-IV on cholesteryl ester transfer protein. Journal of Lipid Research 35, 982–991.CrossRefGoogle Scholar
Inazo, A, Brown, ML, Hestler, CB, Agellon, LB, Koizumi, J, Tulata, K, Marumhama, Y and Tall, AR (1990) Increased high density lipoprotein caused by common CETP gene mutation. New England Journal of Medicine 323, 1234–1238.CrossRefGoogle Scholar
Inazu, A, Koizumi, J, Mabuchi, H, Kajinami, K and Takeda, R (1992) Enhanced cholesteryl ester transfer protein activities and abnormalities of high density lipoproteins in familial hypercholesterolemia. Hormone Metabolism Research 24, 284–288.CrossRefGoogle ScholarPubMed
Hannuksela, ML, Liinamaa, MJ, Kesaniemi, YA and Slolainen, MJ (1994) Relation of polymorphisms in the cholesterol ester transfer protein gene to transfer protein activity and plasma lipoprotein levels in alcohol drinkers. Atherosclerosis 110, 34–44.CrossRefGoogle ScholarPubMed
Jones, RJ, Owens, D, Brennan, C, Collins, PB, Johnson, AH and Tomkin, GH (1996) Increased esterification of cholesterol and transfer of cholesterol ester to apo-B containing lipoproteins in type 2 diabetes: relationship to serum lipoproteins A-I and A-II. Atherosclerosis 119, 151–157.CrossRefGoogle ScholarPubMed
Kahri, J, Mikko, S and Taskinen, MR (1994) Plasma cholesteryl ester transfer protein activity in non insulin dependent diabetic patients with and without coronary artery disease. Metabolism 43, 1498–1502.CrossRefGoogle ScholarPubMed
Kahri, J, Syvanne, M and Taskinen, MR (1998) Plasma cholesteryl ester transfer protein activity in non-insulin-dependent diabetic patients with and without coronary artery disease. Metabolism 43, 1498–1502.CrossRefGoogle Scholar
Karpe, F, Steiner, G, Olivercrona, T, Carlson, LA and Hamsten, A (1993) Metabolism of triglyceride rich lipoproteins during alimentary lipaemia. Journal of Clinical Investigation 91, 748–758.CrossRefGoogle Scholar
Koizumi, J, Inazu, A, Yagi, K, Koizumi, I, Kajinami, K, Miyamoto, S, Moulin, P, Tall, AR and Mabuchi, H (1991) Serum lipoprotein lipid concentration and composition in homozygous and hetrozygous patients with cholesteryl ester transfer protein deficiency. Atherosclerosis 90, 189–196.CrossRefGoogle Scholar
Kuivenhoven, JA, de Knijff, P and Boer, JAM (1997) Heterogencity at the CETP gene locus: influence on plasma CETP concentrations and HDL cholesterol levels. Arteriosclerosis, Thrombosis and Vascular Biology 17, 560–568.CrossRefGoogle Scholar
Kuivenhoven, JA, Jukema, JW, Zwinderman, AZ, Knijff, P, McPherson, R, Bruschke, AVG, Lie, KI and Kastelein, JP (1998) The role of a common variant of the cholesterol ester transfer protein gene in the progression of coronary atherosclerosis. New England Journal of Medicine 338, 86–93.CrossRefGoogle ScholarPubMed
Kondo, IK, Berg, D, Drayna, D and Lawn, R (1989) DNA polymorphism at the locus for human cholesteryl ester transfer protein is associated with high density lipoprotein cholesterol and apolipoprotein levels. Clinical Genetics 35, 49–56.CrossRefGoogle ScholarPubMed
Lagrost, L, Florentin, E, Athias, A, Gandjini, H, Lallemant, C and Gambert, P (1995) Evidence for nonesterified fatty acids as modulators of neutral lipid transfers in normolipidemic plasma. Arteriosclerosis, Thrombosis and Vascular Biology 15, 1388–1396.CrossRefGoogle Scholar
Lagrost, L, Persegol, C, Lallemant, C and Gambert, P (1994) Influence of apolipoprotein composition of high density lipoprotein particles on cholesteryl ester transfer activity. Particles containing various proportions of apolipoproteins AI and AII. Journal of Biological Chemistry 269, 3189–3197.CrossRefGoogle ScholarPubMed
Lassel, TS, Guerin, M, Auboiron, S, Chapman, MJ and Guy-Gaurd, B (1998) Preferential cholesteryl ester acceptor among triglyceride rich lipoproteins during alimentary lipemia in normolipidemic subjects. Arteriosclerosis, Thrombosis and Vascular Biology 18, 65–74.CrossRefGoogle ScholarPubMed
Lottenberg, AM, Nunesm, VS, Lottenberg, SA, Shimabukuro, AF, Carrilho, AJ, Malagutti, S, McPherson, R and Quintao, EC (1996) Plasma cholesteryl ester synthesis, cholesteryl ester transfer protein concentration and activity in hypercholesterolaemic women: effects of the degree of saturation of dietary fatty acids in the fasting and postprandial states. Atherosclerosis 126, 265–275.CrossRefGoogle ScholarPubMed
Lottenberg, SA, Lottenberg, AM, Nunes, VS, MacPherson, R and Quintao, EC (1996) Plasma cholesteryl ester transfer protein concentration, high density lipoprotein cholesterol esterification and transfer rates to lighter density lipoproteins in the fasting state and after a test meal are similar in type II diabetics and normal controls. Atherosclerosis 127, 81–90.CrossRefGoogle ScholarPubMed
Mann, CJ (1991) Mechanism of plasma cholesteryl transfer in hypertriglyceridaemia. Journal of Clinical Investigation 6, 2059–2066.CrossRefGoogle Scholar
MacPherson, R, Agnani, G, Lau, P, Fruchart, JC, Edgar, AD and Marcel, YL (1996) Role of Lp A-1 and Lp A-1/A-II in cholesteryl ester transfer protein mediated neutral lipid transfer studies in normal subjects and in hypertriglyceridemic patients before and after fenofibrate therapy. Arteriosclerosis, Thrombosis and Vascular Biology 16, 1340–1346.CrossRefGoogle Scholar
Patsch, JR, Prasad, S, Gotto, AM and Olivecrona, GB (1984) Postprandial lipaemia; A key for the conversion of high density lipoprotein2 into high density lipoprotein3 by hepatic lipase. Journal of Clinical Investigation 74, 2017–2023.CrossRefGoogle ScholarPubMed
Patsch, JR, Prasad, S, Gotto, AM and Patsch, W (1987) High density lipoprotein-2. Relationship of the plasma levels of this lipoprotein species to its composition, to the magnitude of postprandial lipaemia, and to the activities of lipoprotein lipase and hepatic lipase. Journal of Clinical Investigation 80, 341–347.CrossRefGoogle Scholar
Quinet, EM (1990) Atherogenic diets increases cholesteryl ester transfer protein messenger RNA levels in rabbit. Journal of Clinical Investigation 85, 357–363.CrossRefGoogle ScholarPubMed
Savolainen, MJ, Hannuksela, M, Seppanen, S, Kervinen, K and Kesaniemi, YA (1990) Increased high density lipoprotein in alcoholics is related to low cholesteryl ester transfer protein activity. European Journal of Clinical Investigation 20, 593–599.CrossRefGoogle ScholarPubMed
Skinner, ER (1994) High density lipoproteins. Current Opinions in Lipidology 5, 241–247.CrossRefGoogle Scholar
Tall, AR (1986) Plasma lipid transfer proteins. Journal of Lipid Research 27, 361–368.CrossRefGoogle ScholarPubMed
Tall, AR (1993) Plasma cholesteryl ester transfer protein. Journal of Lipid Research 34, 1255–1274.CrossRefGoogle ScholarPubMed
Tato, F, Vega, GL and Grundy, SM (1997) Determinants of plasma HDL-cholesterol in hypertriglyceridemic patients. Role of cholesterol ester transfer protein and lecithin cholesteryl acyl transferase. Arteriosclerosis, Thrombosis and Vascular Biology 17, 56–63.CrossRefGoogle ScholarPubMed
Tato, F, Vega, GL, Tall, AR and Grundy, SM (1995) Relation between cholesterol ester transfer protein activities and lipoprotein cholesterol in patients with hypercholesterolemia and combined hyperlipidaemia. Arteriosclerosis, Thrombosis and Vascular Biology 15, 112–120.CrossRefGoogle Scholar