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Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa–Reply by Pajari & Mutanen

Published online by Cambridge University Press:  09 March 2007

Anne-Maria Pajari
Affiliation:
Department of Applied Chemistry and MicrobiologyPO Box 27 00014University of HelsinkiFinland
Marja Mutanen
Affiliation:
Department of Applied Chemistry and MicrobiologyPO Box 27 00014University of HelsinkiFinland
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Abstract

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Type
Nutrition Discussion Forum
Copyright
Copyright © The Nutrition Society 2003

References

Black, J (2001) Protein kinase C isozymes in colon carcinogenesis: guilt by omission. Gastroenterology 120, 18681872.CrossRefGoogle ScholarPubMed
Cook, D, Fry, M, Hughes, K, Sumathipala, J, Woodgett, J & Dale, T (1996) Wingless inactivates glycogen synthase kinase-3 via an intracellular signaling pathway which involves a protein kinase C. EMBO Journal 15, 45264536.CrossRefGoogle ScholarPubMed
Davidson, LA, Aymond, CM, Jiang, Y-H, Turner, ND, Lupton, JR & Chapkin, RS (1998) Non-invasive detection of fecal protein kinase C βII and ζ messenger RNA: putative biomarkers for colon cancer. Carcinogenesis 19, 253257.CrossRefGoogle ScholarPubMed
Gökmen-Polar, Y, Murray, NR, Velasco, MA, Gatalica, Z & Fields, AP (2001) Elevated protein kinase C βII is an early promotive event in colon carcinogenesis. Cancer Research 61, 13751381.Google ScholarPubMed
Kinzler, KW & Vogelstein, B (1996) Lessons from hereditary colon cancer. Cell 87, 159170.CrossRefGoogle Scholar
Murray, NR, Davidson, LA, Chapkin, RS, Gustafson, WC, Schattenberg, DG & Fields, AP (1999) Overexpression of protein kinase C βII induces colonic hyperproliferation and increased sensitivity to colon carcinogenesis. Journal of Cell Biology 145, 699711.CrossRefGoogle ScholarPubMed
Mutanen, M, Pajari, A-M & Oikarinen, S (2000) Beef induces and rye bran prevents formation of intestinal polyps in APCMin mice: relation to β-catenin and PKC-isoforms. Carcinogenesis 21, 11671173.CrossRefGoogle Scholar
Pajari, A-M, Häkkänen, P, Duan, R-D & Mutanen, M (1998) Role of red meat and arachidonic acid in protein kinase C activation in rat colonic mucosa. Nutrition and Cancer 32, 8694.CrossRefGoogle ScholarPubMed
Pajari, A-M, Oikarinen, S, Gråsten, S & Mutanen, M (2000) Diets enriched with cereal brans or inulin modulate protein kinase C activity and isozyme expression in rat colonic mucosa. British Journal of Nutrition 84, 635643.CrossRefGoogle ScholarPubMed
Weller, SG, Klein, IK, Penington, RC & Karnes, WE Jr (1999) Distinct protein kinase C isozymes signal mitogenesis and apoptosis in human colon cancer cells. Gastroenterology 117, 848857.CrossRefGoogle ScholarPubMed