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Changes in vitamin-D metabolites and parathyroid hormone in plasma following cholecalciferol administration to pre- and postmenopausal women in the Netherlands in early spring and to postmenopausal women in Curaçao

Published online by Cambridge University Press:  09 March 2007

Fiona R. M. Van Der Klis ,
Jan H. P. Jonxis ,
Jasper J. Van Doormaal ,
Peter Sikkens ,
Alejandro E. C. Saleh  and
Frits A. J. Muskiet
Fiona R. M. Van Der Klis
Affiliation:
Central Laboratory for Clinical Chemistry, University Hospital Groningen, Oostersingel 59, PO Box 30.001, 9700 RB Groningen, The Netherlands
Jan H. P. Jonxis
Affiliation:
Retired Professor of Paediatrics, Rijksstraatweg 65, 9752 AC Haren, The Netherlands
Jasper J. Van Doormaal
Affiliation:
Department of Internal Medicine, University Hospital Groningen, The Netherlands
Peter Sikkens
Affiliation:
Hoofdweg 86, 9761 EK Eelde, The Netherlands
Alejandro E. C. Saleh
Affiliation:
Department of Internal Medicine, St Elisabeth Hospital, Willemstad, Curaçao, The Netherlands Antilles
Frits A. J. Muskiet
Affiliation:
Central Laboratory for Clinical Chemistry, University Hospital Groningen, Oostersingel 59, PO Box 30.001, 9700 RB Groningen, The Netherlands
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Abstract

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To study the effect on plasma 25-hydroxycholecalciferol (25(OH)D), 1,25-dihydroxycholecalciferol (1,25(OH)2D) and parathyroid hormone (PTH) we supplemented premenopausal (aged 30 (SD 7) years) and postmenopausal (aged 61 (SD 2) years) white women living in The Netherlands in late winter/early spring, and elderly black and white women (aged 75 (SD 6) years) living in Curacao (Dutch Antilles) with either 10 or 20µpg cholecalciferol/d for 4, 5 and 9 weeks respectively. Baseline plasma 25(OH)D concentration of Dutch women was lower than that of Curacao women. Postmenopausal Dutch women had a higher PTH concentration in plasma than premenopausal Dutch and postmenopausal Curaçao women. There were no differences in plasma 1,25(OH)2D. Cholecalciferol administration increased 25(OH)D in all groups, 1,25(OH)2D in postmenopausal Curaçao women and PTH in postmenopausal Curaçao women and premenopausal Dutch women. Serum and urinary Ca and phosphate concentrations did not change. There were no response differences between 10 and 20 µg doses. Oral cholecalciferol administration (either 10 or 20 µg/d) to women living at northern latitudes in late winter/early spring increased 25(OH)D levels to the baseline levels of elderly people living in the tropics.

Keywords

CholecalciferolParathyroid hormoneOsteoporosis
Type
Vitamin D supplementation in pre- and postmenopausal women
Information
British Journal of Nutrition , Volume 75 , Issue 4 , April 1996 , pp. 637 - 646
Copyright
Copyright © The Nutrition Society 1996

References

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