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Carotene dioxygenase (EC 1. 13. 11. 21) activity in rat intestine: effects of vitamin A deficiency and of pregnancy

Published online by Cambridge University Press:  09 March 2007

Laurence Villard  and
C. J. Bates
Laurence Villard
Affiliation:
Medical Research Council, Dunn Nutrition Laboratory, Milton Road, Cambridge CB4 IXJ
C. J. Bates
Affiliation:
Medical Research Council, Dunn Nutrition Laboratory, Milton Road, Cambridge CB4 IXJ
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Abstract

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1. Female weanling rats were fed on a purified diet containing either no vitamin A, apart from traces present in casein (deficient groups), or the same diet containing 1.55 mg retinol as retinyl acetate/kg (control groups). In one experiment the deficient groups were given 1 μg retinol/d after 10 weeks, to permit successful reproduction under conditions of marginal vitamin A status. A proportion were mated at 11 weeks after weaning, and fetal development was permitted for 7 d or for 20 d before killing.

2. Carotene dioxygenase (EC 1. 13.11.21) activity was measured in a supernatant fraction from intestinal mucosal scrapings. For each group, activity was 20–30% greater in the vitamin-A-deficient animals than in the controls, and the difference reached statistical significance for the virgin and 7 d pregnant animals in the first experiment (severe deficiency) and for the 20 d pregnant animals in the second experiment (less-severe deficiency).

3. It is suggested that low tissue vitamin A levels may feedback to increase carotene dioxygenase activity, by mechanisms at present unknown, presumably to ensure a more efficient use of precursor dietary carotenoids.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 1 , July 1986 , pp. 115 - 122
Copyright
Copyright © The Nutrition Society 1986

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