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Biotin supply by large bowel bacteria in minipigs: Evidence from intracaecal avidin

Published online by Cambridge University Press:  09 March 2007

Johanne Scholtissek ,
Christian A. Barth ,
Hans Hagemeister  and
Martin Frigg
Johanne Scholtissek
Affiliation:
Bundesanstalt für Milchforschung, D-2300 Kiel 1, Federal Republic of Germany
Christian A. Barth
Affiliation:
Bundesanstalt für Milchforschung, D-2300 Kiel 1, Federal Republic of Germany
Hans Hagemeister
Affiliation:
Bundesanstalt für Milchforschung, D-2300 Kiel 1, Federal Republic of Germany
Martin Frigg
Affiliation:
Department of Animal Nutrition and Health, F. Hoffmann–La-Roche, CH 4002 Bade, Switzerland
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Abstract

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The influence of a change of colonic availability of biotin on biotin status was studied. This was done by inhibition of biotin absorption by intracaecal avidin infusion. Five adult minipigs with a permanent caecal ‘T’ cannula were fed on a semi-synthetic, biotin-deficient diet for 4 months. Following an 8-week adaptation period there were nine sequential 1-week infusion periods with or without oral lactulose or antibiotics. Avidin infusion during weeks 2, 5 and 8 amounted to 18 mg/d (13 U/mg). Plasma biotin concentrations were not changed by avidin infusions. There was a significant average 84% rise in faecal biotin excretion during the avidin periods. Urinary biotin output following avidin decreased by 21 %. This is taken as evidence that biotin synthesized by colonic bacteria is available for host metabolism. A rough estimate shows that under basal conditions 1.7–17% of the metabolic allowance may be covered by this metabolic route.

Keywords

Biotin synthesisBiotin absorptionColonic microfloraMinipig
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 64 , Issue 3 , November 1990 , pp. 715 - 720
Copyright
Copyright © The Nutrition Society 1990

References

Barth, C. A., Frigg, M. & Hagemeister, H. (1986). Biotin absorption from the hindgut of the pig. Journal of Animal Physiology and Animal Nutrition 55, 128–134.CrossRefGoogle Scholar
Bonjour, J.-P. (1984). Biotin. In Handbook of Vitamins, pp. 403–435 [Machlin, L. J., editor]. New York and Basel: Marcel Dekker.Google Scholar
Bowman, B. B. & Rosenberg, I. H. (1987). Biotin absorption by distal rat intestine. Journal of Nutrition 117, 2121–2126.CrossRefGoogle ScholarPubMed
Bryant, K. L., Kornegay, E. T., Knight, J. W., Webb, K. E. & Notter, D. R. (1985). Supplemental biotin for swine. I. Influence on feedlot performance, plasma biotin and toe lesions in developing gilts. Journal of Animal Science 60, 136–144.CrossRefGoogle ScholarPubMed
Buenrostro, J. L. & Kratzer, F. H. (1983). Effect of lactobacillus inoculation and antibiotic feeding of chickens on availability of dietary biotin. Poultry Science 62, 2022–2029.CrossRefGoogle ScholarPubMed
Christensen, K. (1980). Evaluation of the background for determination of vitamin requirements in pigs. Livestock Production Science 7, 569–590.CrossRefGoogle Scholar
Davidson, S., Passmore, R., Brock, J. F. & Truswell, A. S. (1979). Water-soluble vitamins. In Human Nutrition and Dietetics, 7th ed., pp. 15G–151 [Davidson, S. and Passmore, R., editors]. Edinburgh, London, New York: Churchill Livingstone.Google Scholar
Deutsche Gesellschaft für Ernährung (1985). Empfehlungen für die Nährstoffzufuhr, 4th revised ed., p. 82. Frankfurt am Main: Umschau Verlag.Google Scholar
Food and Nutrition Board (1980). Recommended Dietary Allowances. Washington, DC: National Academy of Sciences.Google Scholar
Frigg, M. & Brubacher, G. (1976). Biotin deficiency in chicks fed a wheat-based diet. International Journal of Vitamin Nutrition Research 46, 314–321.Google ScholarPubMed
Grundy, W. E., Freed, M., Johnson, H. C., Henderson, C. R., Berryman, G. H. & Friedmann, T. E. (1947). The effect of phthalylsulfathiazole (sulfathalidine) on the excretion of B-vitamins by normal adults. Archives of Biochemistry and Biophysics 15, 187–194.Google ScholarPubMed
György, P. & Langer, B. W. Jr (1968). Biotin. In The Vitamins, vol. 2, 2nd ed., pp. 316–322 [Sebrell, W. H. Jr and Harris, R. S., editors]. London, New York: Academic Press.Google Scholar
Harvey, W. R. (1976). Mixed Model and Maximum Likelihood General Purpose Computer Program. Ohio: Ohio State University.Google Scholar
Kopinski, J. S., Bryden, W. L. & Leibholz, J. (1983). Biotin synthesis and absorption in the pig. Proceedings of the Nutrition Society of Australia 8, 205.Google Scholar
Kopinski, J. S. & Leibholz, J. (1985). Post-ileal absorption of biotin in the pig. Proceedings of the Nutrition Society of Australia 10, 170.Google Scholar
Kopinski, J. S. & Leibholz, J. (1988). Post-ileal absorption of biotin. Proceedings of 4th International Seminar on Digestive Physiology in the PigJablona, Poland.Google Scholar
Kopinski, J. S. & Leibholz, J. (1989). Biotin studies in pigs. 2. The biotin requirement of the growing pig. British Journal of Nutrition 62, 761–766.CrossRefGoogle ScholarPubMed
Markkanen, T. (1960). Studies on the urinary excretion of thiamine, riboflavin, nicotinic acid, pantothenic acid and biotin in achlorhydria and after partial gastrectomy. Acia Medica Scandinavica 169, Suppl 1, 1–55.Google Scholar
Misir, R. & Blair, R. (1986). Effect of biotin supplementation of barley–wheat diet on restoration of healthy feet, legs and skin of biotin-deficient sows. Research in Veterinary Science 40, 212–218.CrossRefGoogle ScholarPubMed
Mosenthin, R., Sauer, W. C., Völker, L. & Frigg, M. (1990). Synthesis and absorption of biotin in the large intestine of pigs. Livestock Production Science 25, 95–103.CrossRefGoogle Scholar
Oppel, T. W. (1942). Studies of biotin metabolism in man. American Journal of the Medical Sciences 204, 856–875.CrossRefGoogle Scholar
Sarett, H. P. (1952). Effect of oral administration of streptomycin on urinary excretion of B vitamins in man. Journal of Nutrition 41, 275–287.CrossRefGoogle Scholar
Sauer, W. C., Mosenthin, R. & Ozimek, L. (1988). The digestibility of biotin in protein supplements and cereal grains for growing pigs. Journal of Animal Science 66, 2583–2589.CrossRefGoogle ScholarPubMed
Searle, S. R. (1971). Linear Models. New York: John Wiley.Google Scholar
Sorrell, M. F., Frank, O., Thomson, A. D., Aquino, H. & Baker, H. (1971). Absorption of vitamins from the large intestine in vivo. Nutrition Reports International 3, 143–148.Google Scholar
Spencer, R. P. & Brody, K. R. (1964). Biotin transport by small intestine of rat, hamster and other species. American Journal of Physiology 206, 653–657.CrossRefGoogle ScholarPubMed
Streiff, K., Völker, L. & Frigg, M. (1986). Availability of biotin from feed ingredients to the growing pig, Proceedings of the 6th International Conference on Production Disease in Farm Animals, pp. 112–115 [McMurray, C. H., editor]. Belfast.Google Scholar
Sydenstricker, V. P., Singel, S. A., Briggs, A. P., De Vaughn, N. M. & Isbell, H. (1942). Observations of the ‘egg white injury’ in man and its cure with a biotin concentrate. Journal of the American Medical Association 118, 1199–1200.CrossRefGoogle Scholar
Tagwerker, F. J. (1977). Biotin in pigs. Nippon Roche Feed Seminars, Tokyo and Osaka: Roche Information Service Bulletin no. 1675. Bask: Hoffmann-La-Roche.Google Scholar
Tagwerker, F. J. (1983). Biotin in poultry and swine nutrition. Feed International 1–9.Google Scholar