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The relationship between serum fatty acids and depressive symptoms in obese adolescents

Published online by Cambridge University Press:  03 October 2022

Sandra Maria Chemin Seabra da Silva*
Affiliation:
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil
Aline de Piano Ganen
Affiliation:
Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Mestrado Profissional em Nutrição: do nascimento à adolescência, Centro Universitário São Camilo, São Paulo, SP, Brasil
Deborah Cristina Landi Masquio
Affiliation:
Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Mestrado Profissional em Nutrição: do nascimento à adolescência, Centro Universitário São Camilo, São Paulo, SP, Brasil
Marcus V.L. Dos Santos Quaresma
Affiliation:
Curso de Nutrição, Centro Universitário São Camilo, São Paulo, SP, Brasil
Debora Estadella
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Departamento de Biociências, Universidade Federal de São Paulo, Santos, SP, Brasil
Lila Missae Oyama
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Lian Tock
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Marco Túlio de Mello
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Escola de Educação Física, Fisioterapia e Terapia Ocupacional, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brasil
Ana Raimunda Dâmaso
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Claudia Maria da Penha Oller do Nascimento
Affiliation:
Programa de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, São Paulo, SP, Brasil Departamento de Fisiologia, Universidade Federal de São Paulo, São Paulo, SP, Brasil
Danielle Arisa Caranti
Affiliation:
Programa de Pós-Graduação Interdisciplinar em Ciências da Saúde, Universidade Federal de São Paulo, Santos, SP, Brasil Departamento de Biociências, Universidade Federal de São Paulo, Santos, SP, Brasil
*
*Corresponding author: Sandra Maria Chemin Seabra da Silva, email nutri@saocamilo-sp.br

Abstract

Depression and obesity are highly prevalent and are considered inflammatory pathologies; in addition, they are also associated with dietary patterns including types of fatty acids (FA). Changes in the FA composition in the brain are determined by changes in the content and quality of dietary and serum FA. The aim of this study was to verify the relationships between serum-free FA, inflammatory processes and depressive symptoms in obese adolescents. This was a cross-sectional study that analysed a database composed of 138 post-pubertal adolescents. Data regarding the depressive symptoms, body composition, glucose metabolism, lipid profile, FA profile, leptin concentration, as well as adiponectin, IL-A, IL-6, IL-10, TNF-α, C-reactive protein and plasminogen activator inhibitor-1 levels of the subjects were collected. A total of 54·6 % of the adolescents presented with depressive symptoms, and there were positive correlations between depressive symptoms and serum saturated fatty acids (SFA) content, body fat, and inflammatory adipokines, such as leptin, IL-6, and the leptin/adiponectin ratio. Moreover, the content of n-3 polyunsaturated fatty acids (PUFA) was negatively correlated with depressive symptoms, suggesting that eicosatrienoic acid (C20:2n6) and dihomo-γ-linolenic acid (C20:3n-6) are independently associated with depressive symptom scores and can be critical predictors of poor mental health in humans. These results point to the relationship between SFA and depressive symptoms in obese adolescents. However, longitudinal studies are needed to confirm the causality between dietary SFA and depression in obese individuals.

Type
Research Article
Copyright
© Universidade Federal de São Paulo, 2022. Published by Cambridge University Press on behalf of The Nutrition Society

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References

Caixeta, HCV & Amato, AA (2020) Factors associated with overweight and abdominal obesity in Brazilian school-aged children: a comprehensive approach. Arch Endocrinol Metab 64, 445453.Google ScholarPubMed
Smith, JD, Fu, E & Kobayashi, MA (2020) Prevention and management of childhood obesity and its psychological and Health comorbidities. Ann Rev Clin Psychol 16, 120.CrossRefGoogle Scholar
Nittari, G, Scuri, S, Petrelli, F, et al. (2019) Fighting obesity in children from European Organization member states. Epidemiological data, medical social aspects, and prevention programs. Clin Ter 170, e223e230.Google Scholar
Riviera, , Cossio, TG, Pedraza, LS, et al. (2014) Childhood and adolescent overweight and obesity in Latin America: a systematic review. Lancet Diab Endocrinol 2, 321332.CrossRefGoogle Scholar
Brazil. Ministry of Health. General Coordination of Food and Nutrition, Department of Health Promotion & Secretariat of Primary Health Care (2019) Atlas of childhood obesity in Brazil. http://189.28.128.100/dab/docs/portaldab/publicacoes/dados_atlas_obesidade.pdf (accessed July 2021).Google Scholar
Wang, S, Sun, Q, Zhai, L, et al. (2019) Prevalence of depression and anxiety syntoms among overweight/obese and non-overweight/nom-obese children/adolescents in China: a systematic review and meta-analysis. Int Environ Res Public Health 16, 117.Google Scholar
Lindberg, L, Hagman, E, Danielsson, P, et al. (2021) Anxiety and depression in children and adolescents with obesity: a nationwide study in Sweden. BMC Med 18, 3039.CrossRefGoogle Scholar
Rao, WW, Zong, QQ, Zhang, JW, et al. (2020) Obesity increases the risk of depression in children and adolescents: results from a systematic review and meta-analysis. J Affect Disord 15, 7885.CrossRefGoogle Scholar
Marques, CG, Dos Santos Quaresma, MVL, Nakamoto, FP, et al. (2021) Does modern lifestyle favor neuroimmunometabolic changes? A path to obesity. Front Nutr 8, 705545.CrossRefGoogle ScholarPubMed
Godos, J, Currenti, W, Angelino, D, et al. (2020) Diet and mental health: review of the recent updates on molecular mechanisms. Antioxidants 9, 113.CrossRefGoogle ScholarPubMed
Fernandes, MF, Mutch, DM & Leri, F (2017) The relationship between fatty acids and diferente depression-related brain regions, and their potential role as biomarkers of response to antidepressants. Nutrients 9, 119.CrossRefGoogle Scholar
Milano, W, Ambrosio, P, Carizzone, F, et al. (2020) Depression and obesity: analysis of common biomarkers. Diseases 8, 119.Google Scholar
Sotoudeh, G, Khosravi, M, Ahmadkhaniha, R, et al. (2019) Erythrocytes polyunsaturated fatty acids mediate relationship between dietary patterns and depression. Int J Vit Nutr Res 90, 417424.Google Scholar
Mac Giollabhui, N, Swistun, D, Murray, S, et al. (2020) Executive dysfunction in depression in adolescence: the role of inflammation and higher body mass. Psychol Med 50, 683691.CrossRefGoogle Scholar
Luo, X, Feng, J, Yang, Z, et al. (2020) High-dose n-3 polyunsaturated fatty acid supplementation might be more superior than low-dose for major depressive disorder in early therapy period: a network meta-analysis. BMC Psychiatr 20, 248256.CrossRefGoogle Scholar
Freitas, HR, Isaac, AR, Malcher-Lopes, R, et al. (2017) Polyunsaturated fatty acids and endocannabinoids in health and disease. Nutrit Neurosci 21, 121.Google ScholarPubMed
Mannan, M, Mamun, A, Doi, S, et al. (2016) Prospective associations between depression and obesity for adolescent males and females – a systematic review and meta-analysis of longitudinal studies. PLOS ONE 10, 118.Google Scholar
Sánchez-Villegas, A, Álvarez-Pérez, J, Toledo, E, et al. (2018) Seafood consumption, n-3 fatty acids intake, and life-time prevalence of depression in the PREDIMED-plus trial. Nutrients 10, 2000.CrossRefGoogle ScholarPubMed
Carvalho-Ferreira, JP, Masquio, DC, Silveira Campos, RM, et al. (2015) Is there a role for leptin in the reduction of depression symptoms during weight loss therapy in obese adolescent girls and boys? Peptide 65, 2028.Google Scholar
Masquio, DCL, Piano-Ganen, A, Oyama, LM, et al. (2016) The role of free fatty acids in the inflammatory and cardiometabolic profile in adolescents with metabolic syndrome engaged in interdisciplinary therapy. J Nutr Biochem 33, 136144.CrossRefGoogle ScholarPubMed
Tanner, JM & Whitehouse, RH (1976) Clinical longitudinal standards for height, weight, weight velocity and stages of puberty. Arch Dis Child 51, 170179.CrossRefGoogle ScholarPubMed
Fields, DA, Higgins, PB & Radley, D (2005) Air-displacement plethysmography: here to stay. Curr Opin Clin Nutr Metab Care 8, 624629.CrossRefGoogle Scholar
Christie, WW (2003) Lipids Analysis. Isolation, Separation, Identification and Lipidomic Analysis. Bridgwater: The Oily Press.Google Scholar
Beck, AT, Ward, CH, Mendelson, M, et al. (1961) An inventory for measuring depression. Arch Gen Psychiatry 4, 561571.CrossRefGoogle ScholarPubMed
Cunha, JA (2001) Manual of the Portuguese version of the Beck Scales. São Paulo: House of the Psychologist.Google Scholar
Tsurutani, Y, Inoue, K, Sugisawa, C, et al. (2018) Increased serum Dihomo-γ-linolenic acid levels are associated with obesity, body fat accumulation, and insulin resistance in japanese patients with type 2 diabetes. Intern Med 57, 29292935.CrossRefGoogle ScholarPubMed
Ishihara, K, Izawa, KP, Kitamura, M, et al. (2019) Serum concentration of dihomo--linolenic acid is associated with cognitive function and mild cognitive impairment in coronary artery disease patients. Prost Leuk Essent Fatty Acids (PLEFA) 158, 132.Google Scholar
Calder, PC (2018) Very long-chain n-3 fatty acids and human health: fact, fiction and the future. Proc Nutr Soc 77, 5272.CrossRefGoogle Scholar
Bouyanfif, A, Jayarathne, S, Koboziev, I, et al. (2019) The Nematode Caenorhabditis elegans as a model organism to study metabolic effects of ω-3 polyunsaturated fatty acids in obesity. Adv Nutr 10, 165178.CrossRefGoogle ScholarPubMed
Yary, T, Tolmunen, T, Lehto, SM, et al. (2017) Serum dihomo-γ-linolenic acid level is inversely associated with the risk of depression. A 21-year follow-up study in general population men. J Affect Disord 213, 151155.CrossRefGoogle ScholarPubMed
Larrieu, T & Layé, S (2018) Food for mood: relevance of nutritional n-3 fatty acids for depression and anxiety. Front Physiol 9, 115.CrossRefGoogle ScholarPubMed
Marx, W, Lane, M, Hockey, M, et al. (2020) Diet and depression: exploring the biological mechanisms of action. Mol Psychiatr 26, 134150.CrossRefGoogle ScholarPubMed
Mendes, NF, Kim, YB, Velloso, LA, et al. (2018) Hypothalamic microglial activation in obesity: a mini-review. Front Neurosci 12, 18.CrossRefGoogle ScholarPubMed
Trebaticka, J, Hradecná, Z, Surovcová, A, et al. (2020) n-3 fatty-acids modulate symptoms of depressive disorder, sérum levels of n-3 fatty acids and n-6/n-3 ratio in children. A randomized, double-blind and controlled trial. Psychiatry Res 287, 112910112920 CrossRefGoogle Scholar
Schacky, C (2020) Importance of EPA and DHA blood levels in brain structure and function. Nutrients 13, 118.Google Scholar
Bremner, JD, Moazzami, K, Wittbrodt, MT, et al. (2020) Diet, stress and mental health. Nutrients 12, 2428.CrossRefGoogle ScholarPubMed
Shabbir, F, Patel, A, Mattison, C, et al. (2013) Effect of diet on serotonergic neurotransmission in depression. Neurochem Int 62, 324329.CrossRefGoogle ScholarPubMed
Estadella, D, da Penha Oller do Nascimento, CM, Oyama, LM, et al. (2013) Lipotoxicity: effects of dietary saturated and transfatty acids. Mediators Inflamm 2013, 137579.CrossRefGoogle ScholarPubMed
Potalla, JV, Talley, JA, Churchill, SW, et al. (2012) Red blood cell fatty acids are associated with depression in a case-control study of adolescentes. Prostaglandins Leukot Essent Fatty Acids 86, 161165.CrossRefGoogle Scholar
WHO World Health Organization (2003) Population Nutrient Intake Goals for Preventing Diet-Related Chronic Diseases. http://www.who.int/nutrition/topics/5_population_nutrient/en/index.html (accessed July 2021). Google Scholar
Liao, Y, Xie, B, Zhang, H, et al. (2019) Efficacy of n-3 PUFAs in depression: a meta-analysis. Transl Psychiatr 9, 19.CrossRefGoogle Scholar
Scola, G, Versace, A, Metherel, AH, et al. (2018) Alterations in peripheral fatty acid composition in bipolar and unipolar depression. J Affect Dis 233, 8691.CrossRefGoogle ScholarPubMed
Zhang, R, Sun, J, Li, Y, et al. (2020) Associations of n-3, n-6 fatty acids intakes and n-6:n-3 ratio with the risk of depressive symptoms: NHANES 2009–2016. Nutrients 12, 114.CrossRefGoogle Scholar
Tsuboi, H, Watanabe, M, Kobayashi, F, et al. (2013) Associations of depressive symptoms with serum proportions of palmitic and arachidonic acids, and α-tocopherol effects among male population – a preliminary study. Clin Nutr 32, 289293.CrossRefGoogle ScholarPubMed
Thesing, CS, Bot, M, Milaneschi, Y, et al. (2018) n-3 and n-6 fatty acid levels in depressive and anxiety disorders. Psychoneuroendocrinology 87, 5362.Google ScholarPubMed
Gabbay, V, Feed, RD, Alonso, CM, et al. (2019) A double-blind placebo-controlled trial of n-3 fatty acids as a monotherapy for adolescent depression. J Clin Psychiatr 79, 117.Google Scholar
Khana, P, Chattu, V & Aeri, B (2019) Nutritional aspects of depression in adolescents – a systematic review. Int J Prev Med 10, 19.Google Scholar

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