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Higher habitual dietary flavonoid intake associates with lower central blood pressure and arterial stiffness in healthy older adults

Published online by Cambridge University Press:  23 August 2021

Benjamin H. Parmenter*
Affiliation:
School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Australia
Kevin D. Croft
Affiliation:
School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Australia
Lachlan Cribb
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Matthew B. Cooke
Affiliation:
School of Health Sciences, Swinburne University of Technology, Melbourne, Australia
Catherine P. Bondonno
Affiliation:
Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia Medical School, University of Western Australia, Perth, Australia
Ana Lea
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Grace M. McPhee
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Mrudhula Komanduri
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Karen Nolidin
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Karen Savage
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Matthew P. Pase
Affiliation:
Turner Institute for Brain and Mental Health, Monash University, Melbourne, Australia Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA
Jonathan M. Hodgson
Affiliation:
Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia Medical School, University of Western Australia, Perth, Australia
Con Stough
Affiliation:
Centre for Human Psychopharmacology, Swinburne University of Technology, Melbourne, Australia
Nicola P. Bondonno
Affiliation:
School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Australia Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia
*
*Corresponding author: Benjamin H. Parmenter, email benjamin.parmenter@research.uwa.edu.au

Abstract

Flavonoids have shown anti-hypertensive and anti-atherosclerotic properties: the impact of habitual flavonoid intake on vascular function, central haemodynamics and arterial stiffness may be important. We investigated the relationship between habitual flavonoid consumption and measures of central blood pressure and arterial stiffness. We performed cross-sectional analysis of 381 non-smoking healthy older adults (mean age 66·0 (sd 4·1) years; BMI, 26·4 (sd 4·41) kg/m2; 41 % male) recruited as part of the Australian Research Council Longevity Intervention study. Flavonoid intake (i.e. flavonols, flavones, flavanones, anthocyanins, isoflavones, flavan-3-ol monomers, proanthocyanidins, theaflavins/thearubigins and total consumption) was estimated from FFQ using the US Department of Agriculture food composition databases. Measures of central haemodynamics and arterial stiffness included systolic blood pressure (cSBP), diastolic blood pressure (cDBP), mean arterial pressure (cMAP) and augmentation index (cAIx). After adjusting for demographic and lifestyle confounders, each sd/d higher intake of anthocyanins ((sd 44·3) mg/d) was associated with significantly lower cDBP (−1·56 mmHg, 95 % CI −2·65, −0·48) and cMAP (−1·62 mmHg, 95 % CI −2·82, −0·41). Similarly, each sd/d higher intake of flavanones ((sd 19·5) mg/d) was associated with ~1 % lower cAIx (−0·93 %, 95 % CI −1·77, −0·09). These associations remained significant after additional adjustment for (1) a dietary quality score and (2) other major nutrients that may affect blood pressure or arterial stiffness (i.e. Na, K, Ca, Mg, n-3, total protein and fibre). This study suggests a possible benefit of dietary anthocyanin and flavanone intake on central haemodynamics and arterial stiffness; these findings require corroboration in further research.

Type
Research Article
Copyright
© The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society

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