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What are the mechanisms of photoreceptor adaptation?

Published online by Cambridge University Press:  04 February 2010

M. Deric Bownds  and
Vadim Y. Arshavsky
M. Deric Bownds
Affiliation:
Laboratory of Molecular Biology, University of Wisconsin, Madison, WI 53706. Electronic mail: bownds@macc.wisc.edu
Vadim Y. Arshavsky
Affiliation:
Harvard Medical School and The Massachusetts Eye and Ear Infirmary, Boston, MA 02114. Electronic mall: vadim@macc.wisc.edu
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Abstract

This article evaluates each of the reactions known to be involved in visual transduction as a potential site for the regulation of light adaptation. Extensive evidence suggests that calcium acts as a feedback messenger at several different points and recent work suggests a role for cGMP in regulating the primary excitatory pathway. A conclusion is that adaptation is likely to be regulated by multiple and redundant mechanisms. The goal of future experimentation will be to determine the relative importance of each of these.

Keywords

calciumcyclic GMPcyclic GMP phosphodiesteraseguanylate cyclaselight adaptationphosphorylationphotoreceptorrhodopsinrod outer segmentstransducin
Type
Research Article
Information
Behavioral and Brain Sciences , Volume 18 , Special Issue 3: An International Journal of Current Research and Theory with Open Peer Commentary , September 1995 , pp. 415 - 424
Copyright
Copyright © Cambridge University Press 1995

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Footnotes

1

Arshavsky's present address is Howe Laboratories, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles St., Boston, MA 02114.