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Cortical plasticity: A proposed mechanism by which genomic factors lead to the behavioral and neurological phenotype of autism spectrum and psychotic-spectrum disorders

Published online by Cambridge University Press:  26 June 2008

Lindsay M. Oberman  and
Alvaro Pascual-Leone
Lindsay M. Oberman
Affiliation:
Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215. loberman@bidmc.harvard.edu apleone@bidmc.harvard.edu
Alvaro Pascual-Leone
Affiliation:
Berenson-Allen Center for Noninvasive Brain Stimulation, Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215. loberman@bidmc.harvard.edu apleone@bidmc.harvard.edu
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Abstract

Crespi & Badcock (C&B) hypothesize that biases toward expression of paternally or maternally imprinted genes lead to the symptoms of autism spectrum disorders (ASD) and psychotic-spectrum disorders (PSD), respectively. We suggest that such genetic risk factors may act by inducing abnormalities in developmental and learning-related plasticity. We provide preliminary evidence of abnormal plasticity in ASD and suggest transcranial magnetic stimulation as a useful tool to investigate as well as influence cortical plasticity.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 31 , Issue 3 , June 2008 , pp. 276 - 277
Copyright
Copyright © Cambridge University Press 2008

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