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Genetic dissection between coeliac disease and dermatitis herpetiformis in sib pairs

Published online by Cambridge University Press:  13 December 2002

K. KARELL
Affiliation:
FRC Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland
I. KORPONAY-SZABO
Affiliation:
Heim Pál Children's Hospital, Ullöi ut 86, H-1089 Budapest, Hungary
Zs. SZALAI
Affiliation:
Heim Pál Children's Hospital, Ullöi ut 86, H-1089 Budapest, Hungary
P. HOLOPAINEN
Affiliation:
FRC Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland
K. MUSTALAHTI
Affiliation:
Paediatric Research Centre, Building FM3, 33014 University of Tampere, Finland
P. COLLIN
Affiliation:
Paediatric Research Centre, Building FM3, 33014 University of Tampere, Finland
M. MÄKI
Affiliation:
Paediatric Research Centre, Building FM3, 33014 University of Tampere, Finland
J. PARTANEN
Affiliation:
FRC Blood Transfusion Service, Kivihaantie 7, 00310 Helsinki, Finland
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Abstract

Gluten sensitive enteropathy has various manifestations, of which the two major forms are classical coeliac disease (cCD) and dermatitis herpetiformis (DH). In cCD predominantly the small intestine is affected, whereas in DH also the skin is affected showing typical rash and IgA deposits. The symptoms in both forms are dependent on gluten intake. The factors diversifying these two clinical outcomes are unknown. In the present report we evaluated the role of the major genetic susceptibility locus, HLA DQ, in 25 families, in which both forms of the disease, cCD and DH, occurred in siblings. By using the family-based approach it can be assumed that within each family variation in environmental factors is substantially lower than in the standard case-control setting, and also the problems related to population stratification can be avoided. Results from the Finnish family material with 25 discordant and 85 concordant sib pairs, and from additional case-control material comprising 71 unrelated Hungarian DH and 68 cCD patients, together indicated that the HLA DQ locus did not differ between the two major outcomes of gluten sensitive enteropathy. The non-HLA DR;DQ factors are critical for the different clinical manifestations of gluten sensitivity.

Type
Research Article
Copyright
© University College London 2002

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