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Association of a polymorphism at the 5′-region of the angiotensin II type 1 receptor with hypertension

Published online by Cambridge University Press:  23 October 2000

N. TAKAHASHI ,
H. MURAKAMI ,
K. KODAMA ,
F. KASAGI ,
M. YAMADA ,
T. NISHISHITA  and
T. INAGAMI
N. TAKAHASHI
Affiliation:
Department of Genetics, Radiation Effects Research Foundation, 5–2 Hijiyama Park, Minami-ku, Hiroshima, 732–0815, Japan
H. MURAKAMI
Affiliation:
Department of Genetics, Radiation Effects Research Foundation, 5–2 Hijiyama Park, Minami-ku, Hiroshima, 732–0815, Japan
K. KODAMA
Affiliation:
Department of Clinical Studies, Radiation Effects Research Foundation, 5–2 Hijiyama Park, Minami-ku, Hiroshima, 732–0815, Japan
F. KASAGI
Affiliation:
Department of Statistics, Radiation Effects Research Foundation, 5–2 Hijiyama Park, Minami-ku, Hiroshima, 732–0815, Japan
M. YAMADA
Affiliation:
Department of Clinical Studies, Radiation Effects Research Foundation, 5–2 Hijiyama Park, Minami-ku, Hiroshima, 732–0815, Japan
T. NISHISHITA
Affiliation:
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN, 37232–0146, USA
T. INAGAMI
Affiliation:
Department of Biochemistry, Vanderbilt University, School of Medicine, Nashville, TN, 37232–0146, USA
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Abstract

Molecular variants of individual components of the renin-angiotensin system are thought to contribute to inherited predisposition towards essential hypertension. Using polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) and sequence analysis, we identified seven polymorphisms in the 5′-flanking region of the angiotensin II type 1 receptor (AGTR1/AT1) gene. We conducted a case-control study in a sample from the Japanese population to determine whether polymorphic markers in the 5′-flanking region of the AT1gene were associated with essential hypertension. The study compared 149 hypertensive subjects to 156 normotensive control subjects. A significantly higher frequency of the AT1(−535)*T allele was observed in hypertensive subjects. Evidence was obtained that the AT1(−535)*T allele showed a synergistic effect on risk of hypertension with angiotensin I converting enzyme D allele (ACE*D).

Type
Research Article
Information
Annals of Human Genetics , Volume 64 , Issue 3 , May 2000 , pp. 197 - 205
Copyright
© University College London 2000

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