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Transcriptome changes in muscle of Nellore cows submitted to recovery weight gain under grazing condition

Published online by Cambridge University Press:  09 July 2018

D. A. Fausto ,
A. L. J. Ferraz ,
E. F. Delgado Open the ORCID record for E. F. Delgado [Opens in a new window] ,
S. C. S. Andrade ,
L. L. Coutinho  and
G. L. D. Feijó
D. A. Fausto
Affiliation:
Animal Science Department, ‘Luiz de Queiroz’ College of Agricultural/University of Sao Paulo, Brazil (11 Padua Dias Avenue, 13418 900 Piracicaba, Sao Paulo), Brazil
A. L. J. Ferraz
Affiliation:
Animal Science Department, Mato Grosso do Sul State University, Brazil (University City of Aquidauna, 79200-000), Brazil
E. F. Delgado*
Affiliation:
Animal Science Department, ‘Luiz de Queiroz’ College of Agricultural/University of Sao Paulo, Brazil (11 Padua Dias Avenue, 13418 900 Piracicaba, Sao Paulo), Brazil
S. C. S. Andrade
Affiliation:
Animal Science Department, ‘Luiz de Queiroz’ College of Agricultural/University of Sao Paulo, Brazil (11 Padua Dias Avenue, 13418 900 Piracicaba, Sao Paulo), Brazil
L. L. Coutinho
Affiliation:
Animal Science Department, ‘Luiz de Queiroz’ College of Agricultural/University of Sao Paulo, Brazil (11 Padua Dias Avenue, 13418 900 Piracicaba, Sao Paulo), Brazil
G. L. D. Feijó
Affiliation:
Beef Cattle Research Center/Embrapa, Campo Grande, MS, Brazil (830 Rádio Maia, 79106-550, Campo Grande, Mato Grosso do Sul), Brazil
*
†E-mail: efdelgad@usp.br
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Abstract

The aim of this study was to evaluate transcriptome changes in the muscle tissue of Bos taurus indicus cull cows subjected to recovery weight gain under grazing conditions. In all, 38 Nellore cull cows were divided randomly into two different management groups: (1) Maintenance (MA) and (2) Recovery gain (RG) from weight loss by moderate growth under high forage availability. After slaughter, RNA analysis was performed on the Longissimus thoracis muscle. Semaphorin 4A, solute carrier family 11 member 1, and Ficolin-2 were expressed in the RG, which may indicate an inflammatory response during tissue regrowth. Signaling factors, such as Myostatin, related to fibroblast activation, negative control of satellite cell proliferation in adults and muscle protein synthesis were less abundant in the RG group. The only gene related to anabolic processes that were more abundant in the MA group was related to fat deposition. The genes that were differentially expressed in the experiment showed muscle repair-related changes during RG based on the greater expression of genes involved in inflammatory responses and the lower expression of negative regulators of muscle cell proliferation and hypertrophy.

Keywords

extracellular matrixgrowthinflammatory processprotein metabolismproteases
Type
Research Article
Information
animal , Volume 13 , Issue 2 , February 2019 , pp. 333 - 340
Copyright
© The Animal Consortium 2018 

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Footnotes

a

Present address: Genetic and Evolutionary Biology Department, University de Sao Paulo (Matao street, 14, 05508-090, Sao Paulo, Sao Paulo), Brazil.

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