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Supplemental progesterone during early pregnancy exerts divergent responses on embryonic characteristics in sows and gilts

Published online by Cambridge University Press:  07 January 2020

B. B. D. Muro Open the ORCID record for B. B. D. Muro [Opens in a new window] ,
R. F. Carnevale ,
D. F. Leal ,
M. A. Torres ,
M. V. Mendonça ,
D. H. Nakasone ,
C. H. G. Martinez ,
G. M. Ravagnani ,
M. S. Monteiro  and
A. P. Poor
...Show all authors
B. B. D. Muro*
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
R. F. Carnevale
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
D. F. Leal
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
M. A. Torres
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
M. V. Mendonça
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
D. H. Nakasone
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
C. H. G. Martinez
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
G. M. Ravagnani
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
M. S. Monteiro
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
A. P. Poor
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
S. M. M. K. Martins
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
P. Viau
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
C. A. Oliveira
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
L. H. Pulz
Affiliation:
Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga13635-900, Brazil
R. F. Strefezzi
Affiliation:
Department of Veterinary Medicine, Faculty of Animal Science and Food Engineering, University of São Paulo, Pirassununga13635-900, Brazil
G. W. Almond
Affiliation:
Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC27606, USA
A. F. C. de Andrade
Affiliation:
Department of Animal Reproduction, School of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo05508-270, Brazil
*
†E-mail: bruno.muro@usp.br
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Abstract

Progesterone (P4) plays a key role in pregnancy establishment and maintenance; during early pregnancy, P4 stimulates the production and release of uterine secretions necessary for conceptus growth prior to implantation; therefore, exogenous P4 supplementation may improve embryo development. This study evaluated the effects of supplementation during early pregnancy with long-acting injectable progesterone or altrenogest on embryonic characteristics of sows and gilts. Thus, a total of 32 sows and 16 gilts were used. On day 6 of pregnancy sows and gilts were allocated to one of the following groups: non-supplemented; supplemented with 20 mg of altrenogest, orally, from days 6 to 12 of pregnancy; supplemented with 2.15 mg/kg of long-acting injectable progesterone on day 6 of pregnancy. Animals were killed on day 28 of pregnancy, and ovulation rate, embryo survival, embryo weight, crown-to-rump length, uterine glandular epithelium and endometrial vascularization were assessed. Treatments had no effect on pregnancy rate, embryo survival or endometrial vascular density (P > 0.05). Non-supplemented gilts presented larger and heavier embryos compared to gilts from supplemented groups (P < 0.05). Sows in the altrenogest group presented larger and heavier embryos compared to non-supplemented sows and sows supplemented with long-acting injectable progesterone. In conclusion, supplementation of sows and gilts with progestagen from day 6 of pregnancy can be used as a means to improve embryo survival without deleterious effects.

Keywords

embryo developmentuterine histoarchitectureprogestagenaltrenogestswine
Type
Research Article
Information
animal , Volume 14 , Issue 6 , June 2020 , pp. 1234 - 1240
Copyright
© The Animal Consortium 2020

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