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Hypothalamic protein profiles associated with inhibited feed intake of ducks fed with insufficient dietary arginine

Published online by Cambridge University Press:  07 May 2014

C. Wang ,
A. J. Zheng ,
M. Xie ,
W. Huang ,
J. J. Xie  and
S. S. Hou
C. Wang
Affiliation:
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China Chongqing Academy of Animal Sciences, Chongqing 402460, China
A. J. Zheng
Affiliation:
Feed Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China
M. Xie
Affiliation:
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
W. Huang
Affiliation:
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
J. J. Xie
Affiliation:
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
S. S. Hou*
Affiliation:
Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China
*
† E-mail: houss@263.net
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Abstract

An experiment was conducted to investigate the effect of arginine on feed intake regulation. One hundred and twenty six 1-day-old male White Pekin ducks (Anas platyrhynchos domestica) were randomly were allotted to one of two dietary treatments. The birds were fed diets containing 0.71% (deficient) or 1.27% (sufficient) arginine for 3 weeks. At 21 days of age, feed intake was determined and hypothalamic protein profiles were analyzed using isobaric tags for relative and absolute quantification technique. The birds fed with arginine-deficient diet had a lower final live BW and cumulative feed intake (P<0.01) than those fed with arginine-sufficient diet. A total of 16 proteins were identified in the hypothalamus with >1.5-fold expressional changes between arginine-deficient and -sufficient dietary treatments. Nine of these proteins were upregulated and seven of them were downregulated. The identified proteins could be regrouped into six categories: protein processing, carbohydrate metabolism and energy production, transporter, cytoskeleton, immunity and neuronal development. Dietary arginine deficiency decreased expression of proteins involved in energy production (glycine amidinotransferase, aldolase B fructose-bisphosphate, aconitase, transaldolase, 6-phosphofructokinase type C-like) and oxygen transportation (haemoglobin subunit α expression). The proteomic alterations described here provides valuable insights into the interactions of arginine with appetite.

Keywords

arginineappetitehypothalamusproteomicsducks
Type
Full Paper
Information
animal , Volume 8 , Issue 7 , July 2014 , pp. 1113 - 1118
Copyright
© The Animal Consortium 2014 

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