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Hereditary hydrocephalus internus in a laboratory strain of golden hamsters (Mesocricetus auratus)

Published online by Cambridge University Press:  01 September 2008

S. G. Gebhardt-Henrich ,
J. F. Edwards ,
T. R. Famula ,
H.-P. Lipp  and
A. Steiger
S. G. Gebhardt-Henrich*
Affiliation:
Division of Animal Housing and Welfare, Vetsuisse Faculty Bern, P.0. Box, CH-3001 Bern, Switzerland
J. F. Edwards
Affiliation:
Institute of Animal Pathology, Vetsuisse Faculty Bern, P.O. Box, CH-3001 Bern, Switzerland
T. R. Famula
Affiliation:
Department of Animal Science, University of California Davis, Davis, California 95616, USA
H.-P. Lipp
Affiliation:
Division of Neuroanatomy and Behavior, Institute of Anatomy, University of Zurich, Winterthurerstrasse 190, CH-8057 Zurich, Switzerland
A. Steiger
Affiliation:
Division of Animal Housing and Welfare, Vetsuisse Faculty Bern, P.0. Box, CH-3001 Bern, Switzerland
*
E-mail: sabine.gebhardt@bvet.admin.ch
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Abstract

Golden hamsters of one common laboratory strain had a high incidence of hydrocephalus internus. When a severity score of hydrocephalus was used, a major autosomal recessive locus could be identified. However, when a binary score (hydrocephalus, no hydrocephalus) was used, no such major locus could be detected and results of test matings were not consistent with Mendelian inheritance. Golden hamsters with severe forms of hydrocephalus had a dorsally compressed and ventrally intact hippocampus. Implications for the behavior and well-being of affected hamsters are unknown but researchers using this strain should be aware of the likely presence of hydrocephalus.

Keywords

Mesocricetus auratushydrocephalus internusgeneticshippocampus
Type
Full Paper
Information
animal , Volume 2 , Issue 9 , September 2008 , pp. 1265 - 1272
Copyright
Copyright © The Animal Consortium 2008

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References

Almasy, L, Blangero, J 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. American Journal of Human Genetics 62, 1198–1211.CrossRefGoogle ScholarPubMed
Azzi, GM, Canady, AI, Ham, S, Mitchell, JA 1999. Kaolin-induced hydrocephalus in the hamster: temporal sequence of changes in intracranial pressure, ventriculomegaly and whole-brain specific gravity. Acta Neuropathologica 98, 245–250.CrossRefGoogle ScholarPubMed
Blangero, J, Almasy, L, Goring, H, Williams, J, Dyer, T, Peterson, C 2005. Sequential Oligogenic Linkage Analysis Routines (SOLAR), 3.0.4 edition. Southwest Foundation for Biomedical Research, San Antonio, TX, USA.Google Scholar
Bonney, GE 1986. Regressive logistic models for familial disease and other binary traits. Biometrics 42, 611–625.CrossRefGoogle ScholarPubMed
Breschkin, AM, Haspel, MV, Rapp, F 1976. Neurovirulence and induction of hydrocephalus with parental, mutant and revertant strains of measles virus. Journal of Virology 18, 809–811.CrossRefGoogle ScholarPubMed
Cai, XG, McGraw, G, Pattisapu, JV, von Kalm, L, Willingham, S, Socci, D, Gibson, JS 2000. Hydrocephalus in the H-Tx rat: a monogenic disease? Experimental Neurology 163, 131–135.CrossRefGoogle Scholar
Dahme, M, Bartsch, U, Martini, R, Anliker, B, Schachner, M, Mantei, N 1997. Disruption of the mouse L1 gene leads to malformations of the nervous system. Nature Genetics 17, 346–349.CrossRefGoogle ScholarPubMed
Davis, LE 1981. Communicating hydrocephalus in newborn hamsters and cats following vaccinia virus infection. Journal of Neurosurgery 54, 767–772.CrossRefGoogle ScholarPubMed
Duggirala, R, Williams, JT, Williams-Blangero, S, Blangero, J 1997. A variance component approach to dichotomous trait linkage analysis using a threshold model. Genetic epidemiology 14, 987–992.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Edwards, JF, Gebhardt-Henrich, SG, Fischer, K, Hauzenberger, A, Steiger, A 2006. Hereditary hydrocephalus in laboratory-reared golden hamsters (Mesocricetus auratus). Journal of Veterinary Pathology 43, 523–529.CrossRefGoogle ScholarPubMed
Elston, RC, Namboodiri, KK, Glueck, CJ, Fallat, R, Tsang, R, Leuba, V 1975. Study of the genetic transmission of hypercholesterolemia and hypertriglyceridemia in a 195 member kindred. Annals of human genetics 39, 67–87.CrossRefGoogle Scholar
Forestier, F 2003. Molecular genetics of central nervous system malformations. Child’s Nervous System 19, 440–443.CrossRefGoogle ScholarPubMed
Gale, TF 1978a. Embryotoxic effects of chromium trioxide in hamsters. Environmental Research 16, 101–109.CrossRefGoogle ScholarPubMed
Gale, TF 1978b. A variable embryotoxic response to lead in different strains in hamsters. Environmental Research 17, 325–333.CrossRefGoogle ScholarPubMed
Gattermann, R 1986. Der “Futter-Jungen-Eintragetest” mit Goldhamsterweibchen zum Nachweis pränatal induzierter Störungen. Zeitschrift für Versuchstierkunde 28, 199–203.Google Scholar
Gattermann, R, Fritzsche, P, Neumann, K, Al-Hussein, I, Kayser, A, Abiad, M, Yakti, R 2001. Notes on the current distribution and the ecology of wild golden hamsters (Mesocricetus auratus). Journal of Zoology 254, 359–365.CrossRefGoogle Scholar
Gattermann, R, Fritzsche, P, Weinandy, R, Neumann, K 2002. Comparative studies of body mass, body measurements and organ weights of wild-derived and laboratory golden hamster (Mesocricetus auratus). Laboratory animals 36, 445–454.CrossRefGoogle Scholar
Hong, H-K, Lass, JH, Chakravarti, A 1999. Pleiotropic skeletal and ocular phenotypes of the mouse mutation congenital hydrocephalus (ch/Mf1) arise from a winged helix/forkhead transcription factor gene. Human Molecular Genetics 8, 625–637.CrossRefGoogle Scholar
Hood, RD, Naughton, MJ, Hayes, AW 1976. Prenatal effects of ochratoxin A in hamsters. Teratology 13, 11–14.CrossRefGoogle ScholarPubMed
Janss LLG 1998. MAGGIC: A package of subroutines for genetic analyses with Gibbs sampling. Proceedings of the 6th World Congress on Genetics Applied to Livestock Production (Organizing Committee on 6th WCGLAP), Armidale, Australia, volume 27, pp. 459–460.Google Scholar
Johnson, RT, Johnson, KP 1968. Hydrocephalus following viral infection: the development of aqueductal stenosis developing after experimental mumps virus infection. Journal of Neuropathology and Experimental Neurology 27, 591–606.CrossRefGoogle ScholarPubMed
Jones, HC, Lopman, BA, Jones, TW, Carter, BJ, Depelteau, JS, Morel, L 2000. The expression of inherited hydrocephalus in H-Tx rats. Child’s Nervous System 16, 578–584.CrossRefGoogle ScholarPubMed
Jones, HC, Delpeteau, JS, Carter, BJ, Lopman, BA, Morel, L 2001. Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat. Mammalian Genome 12, 22–26.CrossRefGoogle ScholarPubMed
Jones, HC, Delpeteau, JS, Carter, BJ, Somera, KC 2002. The frequency of inherited hydrocephalus is influenced by intrauterine factors in H-Tx rats. Experimental Neurology 176, 213–220.CrossRefGoogle ScholarPubMed
Jones, HC, Carter, BJ, Morel, L 2003. Characteristics of hydrocephalus expression in the LEW/Jms rat strain with inherited disease. Child’s Nervous System 19, 11–18.CrossRefGoogle ScholarPubMed
Jones, HC, Yehia, B, Chen, G-F, Carter, BJ 2004. Genetic analysis of inherited hydrocephalus in a rat model. Experimental Neurology 190, 79–90.CrossRefGoogle ScholarPubMed
Kadarmideen, HN, Janss, LL 2005. Evidence of a major gene from Bayesian segregation analyses of liability to osteochondral diseases in pigs. Genetics 171, 1195–1206.CrossRefGoogle Scholar
Kiefer, M, Eymann, R, von Tiling, S, Müller, A, Steudel, W-I, Booz, K-H 1998. The ependyma in chronic hydrocephalus. Child’s Nervous System 14, 263–270.CrossRefGoogle ScholarPubMed
Kilham, L, Margolis, G 1969. Hydrocephalus in hamsters, ferrets, rats and mice following inoculations with reovirus type I. I. Virologic studies. Laboratory Investigation 21, 183–188.Google ScholarPubMed
Kohn, DF, Kirk, BE, Chou, SM 1977. Mycoplasma-induced hydrocephalus in rats and hamsters. Infection and Immunity 16, 680–689.CrossRefGoogle Scholar
Kohn, DF, Chinookoswong, N, Wang, J 1984. Mycoplasma pneumoniae induced hydrocephalus in hamsters. Infection and Immunity 46, 619–624.CrossRefGoogle ScholarPubMed
Lagace-Simard, J, Descoteaux, JP, Lussier, G 1982. Experimental pneumovirus infections. 2. Hydrocephalus of hamsters and mice due to infection with human respiratory syncytial virus (RS). American Journal of Pathology 107, 36–40.Google ScholarPubMed
Lynch, M, Walsh, B 1998. Genetics and Analysis of Quantitative Traits. Sinauer Associates, Sunderland, MA, USA.Google Scholar
Lyon, M, Searle, AG 1990. Genetic Variants and Strains of the Laboratory Mouse. Oxford University Press, New York, NY, USA.Google Scholar
Mantovani, A, Maranghi, F, Ricciardi, C, Macri, C, Stazi, AV, Attias, L, Zapponi, GA 1998. Developmental toxicity of carbendazim: comparison of no-observed-adverse-effect level and benchmark dose approach. Food and Chemical Toxicology 36, 37–45.CrossRefGoogle ScholarPubMed
Morin, LP, Wood, RI 2001. Stereotaxic Atlas of the Golden Hamster Brain. Academic Press, San Diego, CA, USA.Google Scholar
Takano, T, Takikita, S, Shimada, M 1999. Experimental mumps virus-induced hydrocephalus: viral neurotropism and neuronal maturity. Neuroreport 10, 2215–2221.CrossRefGoogle ScholarPubMed
Timm, F 1958. Zur Histochemie der Schwermetalle. Das Sulfid-Silber-Verfahren [Histochemistry of heavy metals; the sulfide-silver procedure.]. Deutsche Zeitschrift fur die Gesamte Gerichtliche Medizin 46, 706–711.Google Scholar
Timm, F 1962. Histochemische Lokalisation und Nachweis der Schwermetalle [Histochemical localisation and detection of heavy metals]. Acta Histochemica 3 (Suppl.), 142–148.Google Scholar
Vintzileos, AM, Ingardia, CT, Nochimson, DJ 1983. Congenital hydrocephalus: a review and protocol for perinatal management. Obstetrics & Gynecology 62, 539–549.Google ScholarPubMed
Wahnschaffe, U, Fredow, G, Heintz, P, Löscher, W 1990. Neuropathological studies in a mutant hamster model of paroxysmal dystonia. Movement Disorders 5, 286–293.CrossRefGoogle Scholar
Yoon, CH, Peterson, JS 1977. Linkage group II in the Syrian hamster Linkage between hydrocephalus and cream coat color. The Journal of Heredity 68, 418.CrossRefGoogle Scholar
Yoon, CH, Slaney, J 1972. Hydrocephalus: a new mutation in the Syrian Golden hamster. The Journal of Heredity 63, 344–346.CrossRefGoogle ScholarPubMed
Zhu, S-W, Yee, BK, Nyffeler, M, Winblad, B, Feldon, J, Mohammed, AH 2006. Influence of differential housing on emotional behaviour and neurotrophin levels in mice. Behavioural Brain Research 169, 10–20.CrossRefGoogle ScholarPubMed