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The effect of active immunization against gonadotropin-hormone-releasing-hormone on growth performance and sample joint composition of bulls

Published online by Cambridge University Press:  02 September 2010

G. E. Lobley ,
A. Connell ,
B. Morris ,
R. Anderson ,
J. Clayton ,
P. E. V. Williams  and
I. M. Nevison
G. E. Lobley
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
A. Connell
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
B. Morris
Affiliation:
Department of Biochemistry, University of Surrey, Guildford GU2 5XH
R. Anderson
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. Clayton
Affiliation:
Department of Biochemistry, University of Surrey, Guildford GU2 5XH
P. E. V. Williams
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
I. M. Nevison
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
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Abstract

Forty-six Simmental × British Friesian bull calves were allocated to six treatment groups. In four groups (each of eight animals) half the animals were given a prime injection of gonadotropin-hormone-releasing-hormone (GnRH) either as the decapeptide or as an octapeptide (residues 3 to 10) conjugated to egg albumen. Prime injection times were at 3, 4, 5 or 6 months of age. All animals were boosted with a GnRH conjugate, similar to that used for the prime injection, at 8 months. At 8 months, six other animals were surgically castrated while the remaining eight were left as untreated bull controls. Weight gain and consumption of a barley-based diet offered ad libitum were recorded for individual animals. Blood samples were taken at a minimum of fortnightly intervals and the serum analysed for antibody titre against GnRH, testosterone and insulin-like growth factor 1 (IGF-1). Animals were slaughtered at 12 months and chemical analyses performed on the dissectible material of the 10th rib for protein, lipid, ash and water content. Greater antibody titres and a longer period of low serum testosterone were achieved with the octapeptide conjugate compared with the decapeptide. Serum IGF-1 slowly decreased following both surgical- and effective immuno-castration. There were no significant differences in food intake between the groups. Both steers and the more responsive immunocastrates had higher fat (P < 0·01), lower protein (P < 0·05) and water concentrations (P < 0·01) in tissues from a rib sample joint compared with untreated bulls. As immuno-responsiveness decreased there were indications of compensatory changes in body composition. The technique may be applicable during periods of, for example, mixed grazing for bulls.

Keywords

antibodiesbullscarcass compositionGnRHimmunocastration
Type
Research Article
Information
Animal Production , Volume 55 , Issue 2 , October 1992 , pp. 193 - 202
Copyright
Copyright © British Society of Animal Science 1992

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