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Type 1 Diabetes and Prediabetic State in a Monozygotic Triplet

Published online by Cambridge University Press:  01 August 2014

M. Krokowski ,
M. Abel ,
A. Teodorczyk ,
A. Szadkowska ,
B. Pyrżak ,
B. Rymkiewicz-Kluczyńska  and
J. Bodalski
M. Krokowski*
Affiliation:
Institute of Paediatrics, Medical University of Lodz
M. Abel
Affiliation:
Institute of Paediatrics, Medical University of Lodz
A. Teodorczyk
Affiliation:
Institute of Paediatrics, Medical University of Lodz
A. Szadkowska
Affiliation:
Institute of Paediatrics, Medical University of Lodz
B. Pyrżak
Affiliation:
Department of Paediatric Endocrinology, Medical University of Warsaw, Poland
B. Rymkiewicz-Kluczyńska
Affiliation:
Department of Paediatric Endocrinology, Medical University of Warsaw, Poland
J. Bodalski
Affiliation:
Institute of Paediatrics, Medical University of Lodz
*
Institute of Paediatrics, Medical University of Lodz, Sporna 36/50, 91 738 Lodz, Poland e-mail: m.krokowski@alef.am.lodz.pl

Abstract

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Type 1 diabetes mellitus (IDDM) results from a chronic process of autoimmune destruction of ß cells of the Langerhans islets. The presence of autoantibodies (ICA, GADA, anti-IA2, IAA) in serum preceds the clinical onset of the disease. Genetic predisposition for IDDM is connected with HLA, CTLA-4 and insulin gene region.

The aim of the study was the genetic and immunological analysis of a triplet. One of them developed Type 1 diabetes mellitus. We analysed HLA class II, CTLA-4 and insulin gene polymorphisms in the whole family. Besides, we investigated immunological status of three brothers.

All patients present identical genotype for VNTR loci: D1S80, D17S5 and Apo B, as well as for HLA-DRB1, — DQA1, — DQB1, CTLA-4 gene and all studied insulin gene polymorphisms. That proves their monozigosity. The triplet presents strong genetic predisposition for IDDM. The two patients without overt diabetes have increased levels of ICA, GADA, IA2 and IAA.

Keywords

TripletType 1 diabetesPrediabetesMonozygosityGenetic predispositionHLACTLA-4Insulin gene polymorphismsAutoantibodies
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 47 , Issue 3-4 , October 1998 , pp. 171 - 176
Copyright
Copyright © The International Society for Twin Studies 1998

References

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