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A Search for Stratification-Free Association Between Plasma Lipids and HLA Using Dizygotic Twins

Published online by Cambridge University Press:  01 August 2014

S. S. Winata ,
A. A. Biegel ,
K. W. Kang ,
F. Harmath  and
J. C. Christian
S. S. Winata
Affiliation:
Department of Histology, Udayana University Faculty of Medicine, Bali, Indonesia
A. A. Biegel
Affiliation:
Department of Medicine, Indiana University School of Medicine, Indianapolis
K. W. Kang
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis
F. Harmath
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis
J. C. Christian*
Affiliation:
Department of Medical Genetics, Indiana University School of Medicine, Indianapolis
*
Department of Medical Genetics, 1100 W. Michigan, Indianapolis, IN 46223, USA

Abstract

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A total of 71 pairs of like-sexed dizygotic twins were studied, comparing within-pair differences for plasma total, free and esterified cholesterol, and triglyceride with the number of HLA haplotypes the twins had in common. If associations are present between HLA and the blood lipids studied, the twins with no haplotypes in common would be expected to have the largest within-pair mean square, those with two in common the smallest, and those with one in common an intermediate value. No significant differences were found comparing within-pair mean squares for the variables studied.

Keywords

Plasma lipidsHLACoronary heart disease
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 30 , Issue 3 , July 1981 , pp. 213 - 216
Copyright
Copyright © The International Society for Twin Studies 1981

References

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