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Maternal Plasma Concentrations of Insulin-Like Growth Factor-I (IGF-I) and Human Placental Lactogen (hPL) in Twin Pregnancies

Published online by Cambridge University Press:  01 August 2014

R.R. Kazer ,
E.R. Cheng ,
T.G. Unterman  and
R.P. Glick
R.R. Kazer*
Affiliation:
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois
E.R. Cheng
Affiliation:
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois
T.G. Unterman
Affiliation:
Department of Medicine, Northwestern University Medical School, Chicago, Illinois
R.P. Glick
Affiliation:
Department of Neurosurgery, University of Illinois College of Medicine, and Veterans Administration West Side Medical Center, and Cook County Hospital, Chicago, Illinois
*
Center for Assisted Reproduction, Northwestern Medical Faculty Foundation, Inc., 680 North Lake Shore Drive, Suite 810, Chicago IL 60611, USA

Abstract

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Maternal plasma IGF-I and hPL concentrations were examined in 10 singleton pregnancies and in 11 twin gestations near term. hPL concentrations were higher in the twin pregnancies (14.4 ± 2.4 μg/1 vs 6.9 ± 0.9 μg/1, P < 0.02). In contrast, plasma IGF-I concentrations were similar in the singleton and twin pregnancies (533 ± 45 μg/1 vs 572 ± 60 μg/1, respectively). IGF-I concentrations failed to correlate with hPL concentrations in either group separately or when all subjects were considered together. These data do not support the hypothesis that maternal IGF-I secretion is an hPL-dependent process.

Keywords

TwinsInsulin-like growth factor-IHuman placental lactogen
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 40 , Issue 3-4 , October 1991 , pp. 383 - 387
Copyright
Copyright © The International Society for Twin Studies 1991

References

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