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Inheritance and Alcohol as Factors Influencing Plasma Uric Acid Levels

Published online by Cambridge University Press:  01 August 2014

J.B. Whitfield  and
N.G. Martin
J.B. Whitfield*
Affiliation:
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW, Australia
N.G. Martin
Affiliation:
Department of Population Biology, Research School of Biological Sciences, Australian National University, Canberra
*
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia

Abstract

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Variation in plasma uric acid levels in 206 pairs of male and female twins, aged from 18 to 34 years, was consistent with a simple model including only individual environmental and additive genetic effects and a heritability of h2 = 0.73. Individual environmental variation was estimated to be approximately the same as variation of individuals measured on two occasions. Correlations of DZ pairs were also consistent with sex-linked genetic effects. In men there was a significant genetic correlation with weekly alcohol consumption and as much as 18% of the variation in uric acid levels could be accounted for by genetic variation in alcohol consumption.

Keywords

TwinsUric acidAlcohol
Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 32 , Issue 2 , April 1983 , pp. 117 - 126
Copyright
Copyright © The International Society for Twin Studies 1983

References

REFERENCES

1.Boyle, JA, Grieg, WR, Jasani, MK, Duncan, A, Diver, M, Buchman, WW (1967): Relative role of genetic and environmental factors in the control of serum uric acid levels in normouricaemic subjects. Ann Rheum Dis 26:234–237.CrossRefGoogle Scholar
2.Clark, P, Jardine, R, Martin, NG, Stark, AE, Walsh, RJ (1980): Sex differences in the inheritance of some anthropometric characters in twins. Acta Genet Med Gemellol 29:171–192.Google Scholar
3.Eaves, LJ, Last, KA, Young, PA, Martin, NG (1978): Model-fitting approaches to the analysis of human behaviour. Heredity 41:249–320.Google Scholar
4.Havlik, R, Garrison, R, Fabsitz, R, Feinleib, M (1977): Genetic variability of clinical chemical values. Clin Chem 23:659–662.Google Scholar
5.Jensen, J, Blankenborn, DH, Chin, HP, Sturgeon, P, Ware, AG (1965): Serum lipids and serum uric acid in human twins. J Lipid Res 6:193–205.Google Scholar
6.Lieber, CS, Jones, DP, Losowsky, MS, Davidson, CS (1960): Interrelation of uric acid and ethanol metabolism in man. J Clin Invest 42:1863–1870.Google Scholar
7.Martin, NG, Oakeshott, JG, Gibson, JB, Wilks, AV, Starmer, GA, Whitfield, JB (1981): Prodromus to a twin study of sensitivity to intoxication and alcohol metabolism. Aust NZ J Med 11:140–143.Google Scholar
8.Mather, K, Jinks, JL (1974): “Biometrical Genetics,” 2nd Ed. London: Chapman and Hall, pp 292–293.Google Scholar
9.Mikkelsen, WM, Dodge, HJ, Valkeburg, H (1965): The distribution of serum uric acid values in a population unselected as to gout or hyperuricemia. Am J Med 39:242–251.Google Scholar
10.Park, K-S, Inouye, E, Asaka, A (1980): Plasma and urine uric acid levels: Heritability estimates and correlation with IQ. Jpn J Human Genet 25:193–202.Google Scholar
11.Partanen, J, Bruun, K, Markkanen, T (1966): Inheritance of drinking behaviour. Helsinki: Finnish Foundation for Alcohol Studies.Google Scholar
12.Rao, DC, Laskarzewski, PM, Morrison, JA, Khoury, P, Kelly, K, Glueck, CJ (1982): The Cincinnati lipid research clinic family study: Familial determinants of plasma uric acid. Hum Genet 60:257–261.Google Scholar
13.Rich, RL, Nance, WE, Corey, LA, Boughman, JA (1978): Evidence for genetic factors influencing serum uric acid levels in man. In Nance, WE (ed): “Twin Research Part C: Progress in Clinical and Biological Research.” New York: Alan R Liss, Inc., pp 187–192.Google Scholar
14.Sobrinho-Simoes, M (1965): A sensitive method for the measurement of serum uric acid using hydroxylamine. J Lab Clin Med 65:665–668.Google ScholarPubMed
15.Van Steirteghem, AC, Robertson, EA, Young, DS (1978): Variance components of serum constituents in healthy individuals. Clin Chem 24:212–222.CrossRefGoogle ScholarPubMed
16.Whitfield, JB, Hensley, WJ, Bryden, D, Gallagher, H (1978): Some laboratory correlates of drinking habits. Ann Clin Biochem 15:297–303.CrossRefGoogle ScholarPubMed
17.Williams, GZ, Widdowson, GM, Penton, J (1978): Individual character of variation in time-series studies of healthy people. Clin Chem 24:313–320.Google Scholar
18.Wolfson, WQ, Hunt, HD, Levine, R, Guterman, HS, Cohn, C, Rosenberg, EF, Huddlestun, B, Kadota, K (1949): The transport and excretion of uric acid in man. A sex difference in urate metabolism. J Clin Endocrinol 9:749–767.Google Scholar
19.Wyngaarden, JB, Kelley, WN (1978): Gout. In Stanbury, JB, Wyngaarden, JB, Fredrickson, DS (eds): “The Metabolic Basis of Inherited Disease,” 4th Ed. New York: McGraw-Hill.Google Scholar