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A Genetic Study of Plasma Dopamine Beta Hydroxylase Activity in Man

Published online by Cambridge University Press:  01 August 2014

J. Mendlewicz ,
M. Levitt  and
J. L. Fleiss
J. Mendlewicz*
Affiliation:
New York State Psychiatric Institute, New York, N.Y., USA
M. Levitt
Affiliation:
New York State Psychiatric Institute, New York, N.Y., USA
J. L. Fleiss
Affiliation:
New York State Psychiatric Institute, New York, N.Y., USA
*
Institut de Psychiatrie, 4 Place van Gehuchten, Brussels, 1020, Belgium

Abstract

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Plasma dopamine beta hydroxylase (DBH) activity was determined in MZ twins and in siblings of both sexes. The enzyme activities were found to be virtually identical in MZ twins. DBH activity was less similar in same-sex sibs, but still significantly correlated. These results indicate that plasma DBH activity is genetically determined.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 24 , Issue 1-2 , January 1975 , pp. 105 - 110
Copyright
Copyright © The International Society for Twin Studies 1975

References

REFERENCES

Axelrod, J. 1972. Dopamine β Hydroxilase: regulation of its synthesis and release from nerve terminals. Pharmacol. Rev., 24: 233–243.Google Scholar
Dunner, D.L., Cohn, C.K., Weinshilboum, R.M., Wyatt, R.J. 1973. The activity of dopamine β hydroxylase and methionine activating enzyme in blood of schizophrenic patients. Biol. Psychiatry, 6: 215–220.Google ScholarPubMed
Freedman, L.S., Ohuchi, T., Goldstein, M., Axelrod, F., Fish, I., Dancis, J. 1972. Changes in human serum dopamine-β-hydroxylase activity with age. Nature (Lond.), 236: 310–311.Google Scholar
Frewin, D.B., Downey, J.A., Levitt, M. 1974. The effect of heat, cold and exercise on dopamine β hydroxylase activity in man. Can. J. Physiol. Pharmacol., (in press.).Google Scholar
Gewirtz, G.P., Kopin, I.J. 1970. Release of dopamine β hydroxylase with norepinephrine during cat splenic stimulation. Nature (Lond.), 227: 406–407.Google Scholar
Goldstein, M., Freedman, L.S., Bonnay, M. 1971. An assay for dopamine β hydroxylase activity in tissues and serum. Experientia, 27: 632–633.Google Scholar
Horwitz, D.R., Alexander, R.W., Lovenberg, W., Keiser, H. 1973. Human serum dopamine β hydroxylase. Circ. Res., 32: 594–599.CrossRefGoogle Scholar
Kaufman, S., Friedman, S. 1965. Dopamine β hydroxylase. Pharmacol. Rev., 17: 71–100.Google Scholar
Levitt, M., Frewin, D.B., Co, C.C., Luke, W.K., Downey, J.A. 1975. Plasma dopamine β hydroxylase activity in paraplegic and quadriplegic subjects. Austr. N.Z. J. Med. (in press).Google Scholar
Levitt, M., Mendlewicz, J., Dunner, D.L., Fleiss, J.L., Stallone, F., Lawlor, W., Fieve, R.R. Plasma dopamine β hydroxylase activity in patients with affective disorders (in prep.).Google Scholar
Lieberman, A.N., Freedman, L.S., Goldstein, M. 1972. Serum dopamine β hydroxylase activity in patients with Huntington's chorea and Parkinson's disease. Lancet, 1: 153–154.Google Scholar
Molinoff, P.B., Weinshilboum, R.M., Axelrod, J. 1971. A sensitive enzymatic assay for dopamine β hydroxylase. J. Pharmacol. Expt. Therap., 425–431.Google Scholar
Nagatsu, T., Udenfriend, S. 1972. Photometric assay of dopamine β hydroxylase activity in human blood. Clin. Chem., 18: 980–983.Google Scholar
Ross, S.B., Wetterberg, L., Myrked, M. 1973. Genetic control of plasma dopamine β hydroxylase. Life Sc., 12: 529–532.Google Scholar
Shopsin, B., Freedman, L.S., Goldstein, M., Gershon, S. 1972. Serum dopamine β hydroxylase (DBH) activity and affective states. Psychopharmacologia, 27: 11–16.Google Scholar
Smith, S.M., Penrose, L.S. 1955. Monozygotic and dizygotic twin diagnosis. Ann. Hum. Genet., 19: 273–289.Google Scholar
Viveros, O.H., Arqueros, L., Kirshner, N. 1968. Release of catecholamines and dopamine β hydroxylase from the adrenal medulla. Life Sc., 7: 609–618.CrossRefGoogle Scholar
Weinshilboum, R.M., Axelrod, J. 1971 a. Reduced plasma dopamine β hydroxylase in familial dysautonomia. N. Engl. J. Med., 285: 938–942.Google Scholar
Weinshilboum, R.M., Axelrod, J. 1971 b. Serum dopamine (β hydroxylase activity. Circ. Res., 28: 307–315.Google Scholar
Weinshilboum, R.M., Raymond, F.A., Weidman, W.H. 1973. Serum dopamine β hydroxylase activity: sibling-sibling correlation. Science, 181: 943–945.CrossRefGoogle ScholarPubMed
Wetterberg, L., Gustavson, K.H., Bäckström, M., Ross, S.B., Fröden, O. 1972 a. Low dopamine β hydroxylase activity in Down's syndrome. Clin. Genet., 3: 152–153.Google Scholar
Wetterberg, L., Aberg, H., Ross, S.B., Fröden, O. 1972 b. Plasma dopamine β activity in hypertension and various neuropsychiatric disorders. Scand. J. Clin. Lab. Invest., 30: 283–289.Google Scholar
Wooten, G.F., Cardon, P.V. 1973. Plasma dopamine β hydroxylase activity. Arch. Neurol., 28: 103–106.Google Scholar
Wooten, G.F., Eldridge, R., Axelrod, J., Stern, R.S. 1973. Elevated plasma-dopamine β hydroxylase activity in autosomal dominant torsion dystonia. N. Engl. J. Med., 288: 284–287.Google Scholar