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Dependency of Concordance Probability on Gene Frequencies in Genetic Systems for the Diagnosis of Twin Zygosity. A Graphical Presentation Enabling the Rapid, Optimal Choice of Genetic System

Published online by Cambridge University Press:  01 August 2014

Seppo Sarna*
Affiliation:
Department of Public Health Science, University of Helsinki
Jaakko Kaprio
Affiliation:
Department of Public Health Science, University of Helsinki
*
Department of Public Health Science, Haartmaninkatu 3, SF-00290 Helsinki 29, Finland

Abstract

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The dependency of probabilities of phenotypic concordance of gene frequencies in three-allele genetic systems is presented. A graphical display enables the rapid comparison of the relative effectiveness of different systems, taking into account dominance relationships within each genetic system. Four or more allele systems can also be approximated, while two-allele systems are considered to be special cases of three-allele ones.

Type
Research Article
Copyright
Copyright © The International Society for Twin Studies 1979

References

1.Chakraborty, R (1979): Twin zygosity diagnosis by genetic systems: An efficiency evaluation. Acta Genet Med Gemellol 28:7779, 1979.CrossRefGoogle Scholar
2.Gaines, RE, Elston, RC (1969): On the probability that a twin pair is monozygotic. Am J Hum Genet 21:457465.Google ScholarPubMed
3.Sarna, S (1979): Probabilities of concordance of twins with respect to genetic markers. Acta Genet Med Gemellol: A general formulation. 28:125132, 1979.CrossRefGoogle Scholar
4.Sarna, S, Kaprio, J, Sistonen, P, Koskenvuo, M (1978): Diagnosis of twin zygosity by mailed questionnaire. Hum Hered 28:241254.CrossRefGoogle ScholarPubMed
5.Selvin, S (1977): Efficiency of genetic systems for diagnosis of twin zygosity. Acta Genet Med Gemellol 26:8182.CrossRefGoogle ScholarPubMed
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Dependency of Concordance Probability on Gene Frequencies in Genetic Systems for the Diagnosis of Twin Zygosity. A Graphical Presentation Enabling the Rapid, Optimal Choice of Genetic System
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Dependency of Concordance Probability on Gene Frequencies in Genetic Systems for the Diagnosis of Twin Zygosity. A Graphical Presentation Enabling the Rapid, Optimal Choice of Genetic System
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