Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-27T18:33:02.694Z Has data issue: false hasContentIssue false
  • English
  • Français

Cytogenetische Untersuchungen zur Frage Jahreszeitlicher Schwankung der Spontanen Chromosomenaberrationsrate Beim Menschen

Published online by Cambridge University Press:  01 August 2014

B.R. Deininger  and
H.-D. Rott
B.R. Deininger*
Affiliation:
Institut für Humangenetik und, Anthropologie der Universität Erlangen-Nürnberg
H.-D. Rott
Affiliation:
Institut für Humangenetik und, Anthropologie der Universität Erlangen-Nürnberg
*
Institut für Humangenetik und, Anthropologie der Universität, Bismarckstrasse 10, D-8520 Erlangen, German Federal Republic

Summary

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Monthly chromosomal analyses have been carried out, from December 1971 to November 1972, on 4 male subjects aged 22 to 32. Over a total of 4 710 mitoses examined, the rate of aberrant cells (including gaps) was of 9.1% and there was no difference among individual yearly mean values. The average mitotic index, evaluated on 48 cultures, was of approximately 55‰. Significant differences (P < 0.025) have been found among individual yearly mean values (40-69‰). No seasonal increase of aberrations has been found; however, 12 of the 16 tetraploid cells were found in the winter months. In all subjects, the mitotic index reached its maximum in April-June (P < 0.001). The mitotic index and the percentage of aberrant cells were not shown to be correlated.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 22 , Issue 1 , January 1973 , pp. 19 - 26
Copyright
Copyright © The International Society for Twin Studies 1973

References

LITERATUR

Bochkov, N.P. 1972. Spontaneous chromosome aberrations in human somatic cells. Humangenetik, 16: 159–164.Google Scholar
Gebhart, E. 1970. The treatment of human chromosomes in vitro: results. In: Vogel, F. and Röhrborn, G.: Chemical Mutagenesis in Mammals and Man. Berlin-Heidelberg-New York: Springer Verlag.Google Scholar
Gebhart, E. 1971. Experimentelle Beiträge zum Problem der lokalen Achromasien (Gaps). Humangenetik, 13: 98–107.Google Scholar
Hook, E.B., Healy, K., Powers, M.L., Hatcher, N.H. 1972. A pilot screening study of chromosome breakage in cultured blood cells from newborn infants. Mutat. Res., 16: 428–430.Google Scholar
Littlefield, L.G., Goh, K.-O. 1973. Cytogenetic studies in control men and women. I. Variations in aberration frequencies in 29 709 metaphases from 305 cultures obtained over a three-year period. Cytogenet. Cell Genet., 12: 17–34.Google Scholar
Littlefield, L.G., Goh, K.-O., Klepper, M.B., Joiner, E.E. 1971. Chromosome breakages in women taking oral contraceptives: a two-year study. 4th Int. Congr. Hum. Genet., Paris 1971.Google Scholar
Lubs, H.A., Samuelson, J. 1967. Chromosome abnormalities in lymphocytes from normal human subjects. A study of 3 720 cells. Cytogenetics, 6: 402–411.CrossRefGoogle Scholar
Makino, S., Awa, A.A., Sasaki, M. 1968. Chromosome studies in normal human subjects. Ann. N.Y. Acad. Sci., 155: 679–694.Google Scholar
Meist, H. 1971. Strukturelle Chromosomenaberrationen in den Lymphozyten gesunder Probanden unter dem Einfluß verschiedener Kulturbedingungen. Acta Genet. Med. Gemellol. (Roma), 20: 174–188.Google Scholar
Moorhead, P.S., Nowell, P.C., Mellman, W.J., Battips, D.M., Hungerford, D.A. 1960. Chromosome preparations of leukocytes cultured from human peripheral blood. Exp. Cell Res., 20: 613–616.Google Scholar
Mouriquand, C., Gilly, C., Patet, J., Jalbert, P. 1967. Étude de 1 000 caryotypes chez des sujets non irradiés. C.R. Soc. Biol. (Paris), 161: 341–347.Google Scholar
Patil, S.R., Ruddle, F.H., Lubs, H.A. 1972. The lymphocyte as a dosimeter: comparison of somatic chromosome aberrations in 522 newborn infants and 602 mothers. Humangenetik, 14: 306–313.Google Scholar
Zankl, H., Zang, K.D. 1971. Structural variability of the normal human karyotype. Humangenetik, 13: 160–162.Google Scholar