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Concurrence of Morgagni's Syndrome, Schizophrenia and Adenomatous Goiter in Monozygotic Twins1

Published online by Cambridge University Press:  01 August 2014

Bertha M. Aschner ,
Franz J. Kallmann  and
Leo Roizin
Bertha M. Aschner
Affiliation:
Departments of Medical Genetics and Neuropathology of the New York State PsychiatricInstitute Columbia University, New York 32, N. Y.
Franz J. Kallmann
Affiliation:
Departments of Medical Genetics and Neuropathology of the New York State PsychiatricInstitute Columbia University, New York 32, N. Y.
Leo Roizin
Affiliation:
Departments of Medical Genetics and Neuropathology of the New York State PsychiatricInstitute Columbia University, New York 32, N. Y.

Summary

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Clinical and histopathological data are presented on monozygotic twin sisters concordant as to schizophrenia, Morgagni's syndrome, and adenomatous goiter. The association of the three traits may have been coincidental, but apparently had a common denominator. The genetic theory of Morgagni's syndrome (pointing to autosomal dominance with irregular penetrance and especially low manifestation in the male) is discussed.

Sommario

SOMMARIO

Vengono esposti dei dati clinici ed istopatologici riguardanti due sorelle MZ concordanti quanto a schizofrenia, sindrome di Morgagni e gozzo adenomatoso. La concomitanza di queste tre entità morbose poteva essere accidentale, ma è possibile che risultasse da un denominatore comune. Viene discussa la teoria genetica della sindrome di Morgagni (dominanza autosomica con penetranza irregolare e rara manifestazione nel maschio).

Resumé

RESUMÉ

On o presenté des données histopathologiques concernant des sœurs monozygotiques jumelles qui partageaint des traits communs: la schizophrénie, le syndrome de Morgagni, et goître adénomatique. La concurrence de ces trois traits pouvait être accidentelle mais il est possible qu'elle resultait d'un facteur commun. On a discuté aussi la théorie génétique de syndrome de Morgagni. Ce syndrome indique une dominance autosomale avec une pénétration irrégulière et avec une manifestation particulièrement rare chez le mâle.

Zusammenfassung

ZUSAMMENFASSUNG

Klinischer und histopathologischer Bericht über eineiige Zwillingsschwestern mit weitgehender Konkordanz für Schizophrenie, Morgagni's Syndrom und Adenom der Schilddrüse. Zufälliges Zusammentreffen der drei Krankheitszustände lässt sich nicht ausschliessen, ist aber nicht wahrscheinlich. Die erblichen Beziehungen des Morgagnischen Syndroms sind noch nicht geklärt.

Type
Research Article
Information
Acta geneticae medicae et gemellologiae: twin research , Volume 2 , Issue 3 , September 1953 , pp. 431 - 446
Copyright
Copyright © The International Society for Twin Studies 1953

Footnotes

1

Presented at the fifth annual meeting of the American Society of Human Genetics at Cornell University, Ithaca, New York, September 9, 1952.

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