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Towards a new model for cellular pathophysiology in affective disorder

Published online by Cambridge University Press:  18 September 2015

C. Normann
C. Normann*
Affiliation:
Dept. of Psychiatry, University of Freiburg, Freiburg, Germany
*
Dept. of Psychiatry, University of Freiburg, Hauptstr. 5, 79104 Freiburg, GermanyTel 49-761-2706501, Fax 49-761-2706619, E-mail claus_normann@psyallg.ukl.uni-freiburg.de
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Abstract

The mode of action of serotonin in depression is unclear. We tested the modulation of hippocampal long-term plasticity, a model for learning and memory, by 5-HT and found a selective impairment of long-term depression resulting in a positive modification of synaptic network properties. We hypothetize a role for long-term plasticity in emotional regulation and the pathophysiology of affective disorders.

Keywords

serotoninlong-term plasticityaffective disorderselective serotonin reuptake inhibitors
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 77 - 80
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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