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Therapeutic drug monitoring

Published online by Cambridge University Press:  18 September 2015

J.B.G.M. Noten ,
W.M.A. Verhoeven ,
S. Tuinier  and
D. Touw
J.B.G.M. Noten*
Affiliation:
Ziekenhuisapotheker, Farmaceutisch Laboratorium, Stichting, ZALV, Venray
W.M.A. Verhoeven
Affiliation:
Zenuwarts/A-opleider, respectievelijk psychiater, Vincent van Gogh Instituut voor Psychiatrie, Venray
S. Tuinier
Affiliation:
Zenuwarts/A-opleider, respectievelijk psychiater, Vincent van Gogh Instituut voor Psychiatrie, Venray
D. Touw
Affiliation:
Ziekenhuisapotheker, Apotheek Academisch Ziekenhuis, Vrije Universiteit, Amsterdam
*
ziekenhuisapotheker, Z.A.L.V. Farmaceutisch Laboratorium, Hoenderstraat 95b, 5801 CJ Venray
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Summary

The cytochrome P450 iso-enzyme system plays a key role in the biotransformation of many drugs, including psychotropics. Its activity is determined by both genetic and environmental factors. The most important iso-enzymes for psychiatry in general are P450 IID6, 3A4 and 1A2. Knowledge about the involvement of these enzymes and biotransformation processes is mandatory because of the individual variability in their metabolic capacity. Regular measurement of plasmaconcentrations of (psycho)pharmacological compounds is therefore essential. In addition, the potential value of pheno- and/or genotyping has to be investigated.

Keywords

Cytochrome P450 iso-enzymesgenetic polymorphismbloodplasma concentrationsCytochoom P450 enzymengenetisch polymorphismebloedplasmaconcentraties
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 11 , Issue 1 , March 1999 , pp. 15 - 16
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1999

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References

Literatuur

1.Touw, DJ, Verhoeven, WMA, Noten, JBG. Het cytochroom P450 enzymsysteem: wat is de relevantie voor de praktijk? Deel 1: De iso-enzymen. Acta neuropsychiat 1998; 10: 34–42.CrossRefGoogle Scholar
2.Touw, DJ, Verhoeven, WMA, Noten, JBG. Het cytochroom P450 enzymsysteem: wat is de relevantie voor de praktijk? Deel 2: Interacties. Acta neuropsychiat, 1998; 10: 58–62.CrossRefGoogle Scholar