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The neural correlates of self-paced finger tapping in bipolar depression with motor retardation

Published online by Cambridge University Press:  22 February 2013

Benny Liberg ,
Mats Adler ,
Tomas Jonsson ,
Mikael Landén ,
Christoffer Rahm ,
Lars-Olof Wahlund ,
Maria Kristoffersen-Wiberg  and
Björn Wahlund
Benny Liberg*
Affiliation:
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
Mats Adler
Affiliation:
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
Tomas Jonsson
Affiliation:
Department of Diagnostic Medical Physics, Karolinska University Hospital Huddinge, Stockholm, Sweden
Mikael Landén
Affiliation:
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden
Christoffer Rahm
Affiliation:
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden
Lars-Olof Wahlund
Affiliation:
Department of Neurobiology, Care Sciences and Society, Division of Clinical Geriatrics, Karolinska University Hospital, Stockholm, Sweden
Maria Kristoffersen-Wiberg
Affiliation:
Department of Clinical Science, Intervention and Technology, Division of Medical Imaging and Technology, Karolinska Institutet, Stockholm, Sweden
Björn Wahlund
Affiliation:
Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden Department of Energy and Engineering, Swedish University of Agricultural Sciences, Uppsala, Sweden
*
Benny Liberg, Department of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Psykiatri Sydväst, M 58, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. Tel: +46(0)702423076; Fax: +46(0)7795416; E-mail: benny.liberg@gmail.com
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Abstract

Objective

Motor retardation is a characteristic feature of bipolar depression, and is also a core feature of Parkinson's disease. Within the framework of the functional deafferentiation theory in Parkinson's disease, we hypothesised that motor retardation in bipolar depression is mediated by disrupted subcortical activation, leading to decreased activation of cortical motor areas during finger tapping.

Methods

We used functional magnetic resonance imaging to investigate neural activity during self-paced finger tapping to elucidate whether brain regions that mediate preparation, control and execution of movement are activated differently in subjects with bipolar depression (n = 9) compared to healthy controls (n = 12).

Results

An uncorrected whole-brain analysis revealed significant group differences in dorsolateral and ventromedial prefrontal cortex. Corrected analyses showed non-significant differences in patients compared to controls: decreased and less widespread activation of the left putamen and left pallidum; increased activity in the left thalamus and supplementary motor area; decreased activation in the left lateral pre- and primary motor cortices; absence of activation in the pre-supplementary motor area; activation of the bilateral rostral cingulate motor area.

Conclusion

Both movement preparation and execution may be affected in motor retardation, and the activity in the whole left-side motor circuit is altered during self-initiated motor performance in bipolar depression.

Keywords

magnetic resonance imagingmood disorderParkinson diseasepsychomotor performance
Type
Original Articles
Information
Acta Neuropsychiatrica , Volume 25 , Issue 1 , February 2013 , pp. 43 - 51
Copyright
Scandinavian College of Neuropsychopharmacology 2013

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