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Influence of Propofol on the Mood - a comparative study

Published online by Cambridge University Press:  18 September 2015

P.J. De Keyzer ,
J. D'haese ,
H.A.H. D'haenen  and
F. Camu
P.J. De Keyzer*
Affiliation:
kliniekhoofd, Dienst Psychiatric AZ, VUB
J. D'haese
Affiliation:
diensthoofd, Dienst anesthesiologie, AZ, VUB
H.A.H. D'haenen
Affiliation:
kliniekhoofd, Dienst Psychiatric AZ, VUB
F. Camu
Affiliation:
diensthoofd, Dienst anesthesiologie, AZ, VUB
*
dienst psychiatrie Academisch Ziekenhuis VUB Laarbeeklaan 101 1090 Brussel, België
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Summary

The influence of propofol on mood was evaluated, considering the potential use of propofol as an anesthetic for electroconvulsive therapy. The mood state of 80 psychologically healthy subjects was assessed before and from 1/2 hour till 4 hours after surgery under anesthesia with either propofol or methohexitone. The mood was assessed with the Profile of Mood States (POMS). The propofol group was more elated from one hour until 4 hours after anesthesia (p<0,01 )(factor 1). 1 hour after anesthesia the propofol group was continuously more composed than the methohexitone group (p<0,01) (factor 4) and after two hours the propofol group was more agreeable (p<0,05) (factor 2). Moreover, patients, who received propofol, were less tired (factor 3) and confused (factor 5). It can be concluded that, compared with methohexitone, propofol has a favorable influence on different aspects of mood.

Keywords

propofolmethohexitonemoodProfile of Mood StatespropofolmethohexitonegemoedstoestandProfile of Mood States
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 3 , Issue 4 , December 1991 , pp. 66 - 69
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1991

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References

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