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Immunological aspects of bipolar disorder

Published online by Cambridge University Press:  18 September 2015

R.W. Kupka ,
M.H.J. Hillegers ,
W.A. Nolen ,
N. Breunis  and
H.A. Drexhage
R.W. Kupka*
Affiliation:
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands Stanley Foundation Bipolar Network
M.H.J. Hillegers
Affiliation:
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
W.A. Nolen
Affiliation:
Altrecht Institute for Mental Health Care, Utrecht, The Netherlands Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands Stanley Foundation Bipolar Network
N. Breunis
Affiliation:
Department of Immunology, Erasmus University Rotterdam, The Netherlands
H.A. Drexhage
Affiliation:
Department of Immunology, Erasmus University Rotterdam, The Netherlands
*
Altrecht Institute for Mental Health Care, Vrouwjuttenhof 18, 3512 PZ Utrecht, The Netherlands E-mail r.kupka@altrecht.nl
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Abstract

Introduction: Significant changes in immune function have been found in mood disorders. Controlled studies in bipolar disorder concerning cell-mediated immunity and thyroid autoimmunity are reviewed, and presented together with preliminary findings from our own ongoing study.

Method: Using Medline and other sources, 14 controlled studies as well as some other relevant studies were found.

Results: Bipolar disorder is associated with an acute phase response and activation of the cell-mediated immune system, and with an increased prevalence of antithyroid autoantibodies.

Conclusion: Changes in immune function, in connection with neuroendocrine changes, may provide new hypotheses for the pathophysiology of mood disorders.

Keywords

Bipolar disordercell-mediated immunitythyroid autoimmunitylithium
Type
Articles
Information
Acta Neuropsychiatrica , Volume 12 , Issue 3 , September 2000 , pp. 86 - 90
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 2000

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