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Hypothalamic digoxin and brain function

Published online by Cambridge University Press:  24 June 2014

R. K. Kurup  and
P. A. Kurup
R. K. Kurup*
Affiliation:
Department of Neurology, Medical College Hospital, Trivandrum, Kerala
P. A. Kurup
Affiliation:
Metabolic Disorders Research Center, Trivandrum, Kerala, India
*
Gouri Sadan, T.C.4/1525, North of Cliff House, Kattu Road, Kowdiar PO, Trivandrum, Kerala, India. Tel: 0471 541607; Fax: 91 0471-550782; E-mail: kvgnair@satyam.net.in
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Abstract

Background and objectives:

The study assessed the biochemical differences between right hemispheric-dominant and left hemispheric-dominant individuals. The chemical hemispheric-dominance in various systemic and neuropsychiatric diseases was also studied.

Methods:

The isoprenoid metabolites, digoxin, dolichol and ubiquinone, glycoconjugate metabolism, free radical metabolism and the RBC membrane composition, were studied in individuals with differing hemispheric-dominance. The digoxin levels and RBC membrane Na+-K+ATPase activity were also studied in systemic and neuropsychiatric diseases.

Results:

The results showed that right hemispheric-dominant individuals had elevated digoxin levels, increased free radical production and reduced scavenging, increased tryptophan catabolites and reduced tyrosine catabolites, increased glycoconjugate levels and increased cholesterol : phospholipid ratio of RBC membranes. Left hemispheric-dominant individuals had the opposite patterns. This patterns could be correlated with various systemic and neuropsychiatric diseases.

Conclusion:

Right hemispheric-dominance represents a hyperdigoxinaemic state with membrane sodium–potassium ATPase inhibition. Left hemispheric-dominance represents the reverse pattern with hypodigoxinaemia and membrane sodium–potassium ATPase stimulation. Hemispheric-dominance could predispose to various systemic and neuropsychiatric diseases.

Keywords

cerebral; dominancedigoxindolicholsystemic diseasesubiquinone
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 15 , Issue 2 , April 2003 , pp. 74 - 90
Copyright
Copyright © 2003 Blackwell Munksgaard

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