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Drug-induced psychosis in Parkinson's disease (II): atypicalneuroleptics

Published online by Cambridge University Press:  18 September 2015

E.CH. Wolters ,
G. Tissingh ,
M.A. Kuiper ,
W.A. Zwaan  and
M.W.I.M. Horstink
E.CH. Wolters*
Affiliation:
Afdeling Neurologie, Academisch Ziekenhuis der Vrije Universiteit
G. Tissingh
Affiliation:
Afdeling Neurologie, Academisch Ziekenhuis der Vrije Universiteit
M.A. Kuiper
Affiliation:
Afdeling Neurologie, Academisch Ziekenhuis der Vrije Universiteit
W.A. Zwaan
Affiliation:
Afdeling Psychiatrie, Academisch Ziekenhuis der Vrije Universiteit
M.W.I.M. Horstink
Affiliation:
Afdeling neurologie, Academisch Ziekenhuis Nijmegen.
*
Postbus 7057, 1007 MB Amsterdam, Tel. 020-5482818
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Summary

In this second part of a review on drug-induced psychosis in Parkinson's disease, the characteristics of typical and atypical neuroleptics will be compared and the therapeutic efficacy and the extrapyramidal side-effects of ‘atypical’ antipsychotic drugs will be discussed. These drugs affect serotonergic, adrenergic as well as dopaminergic neurotransmission and are best distinguished from the typical neuroleptics on the basis of the relationship between strong 5-HT2 and weak D2 affinities. Their succes may rely on this spectrum of effects. Clozapine, being the first choice, will be discussed in more detail.

Keywords

Parkinson's diseasedopaminepsychosisatypische neurolepticaclozapineziekte van Parkinsondopaminepsychoseatypische neurolepticaclozapine
Type
Research Article
Information
Acta Neuropsychiatrica , Volume 6 , Issue 3 , September 1994 , pp. 43 - 47
Copyright
Copyright © Scandinavian College of Neuropsychopharmacology 1994

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