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A combination of three plasma bile acids as a putative biomarker for schizophrenia

Published online by Cambridge University Press:  23 November 2020

Yanlin Tao ,
Fang Zheng ,
Donghong Cui ,
Fei Huang  and
Xiaojun Wu Open the ORCID record for Xiaojun Wu [Opens in a new window]
Yanlin Tao
Affiliation:
Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Fang Zheng
Affiliation:
Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Donghong Cui
Affiliation:
Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China Brain Science and Technology Research Center, Shanghai Jiaotong University, Shanghai, People’s Republic of China
Fei Huang*
Affiliation:
Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
Xiaojun Wu*
Affiliation:
Shanghai Key Laboratory of Compound Chinese Medicines, The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, Shanghai R&D Center for Standardization of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China
*
Authors for correspondence: Xiaojun Wu, Email: xiaojunwu320@126.com; Fei Huang, E-mail: Fei_H@hotmail.com
Authors for correspondence: Xiaojun Wu, Email: xiaojunwu320@126.com; Fei Huang, E-mail: Fei_H@hotmail.com
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Abstract

The aim of the present study is to determine whether plasma bile acids (BAs) could be used as an auxiliary diagnostic biomarker to distinguish patients with schizophrenia from healthy controls. Seventeen different BAs were quantitatively measured in plasma of 12 healthy participants and 12 patients with schizophrenia. Then, the data were subjected to correlation and linear discriminant analysis (LDA). The concentrations of cholic acid (CA), taurochenodeoxycholic acid (TCDCA) and taurodeoxycholic acid (TDCA) were significantly decreased in plasma of the schizophrenia patients. Correlation analysis showed the concentrations of CA, TCDCA and TDCA were negatively correlated with schizophrenia. In addition, LDA demonstrated that combination of CA, TCDCA and TDCA with a classification formula could predict correctly classified cases and the accuracy of prediction was up to 95.83%. Combination of the three BAs may be useful to diagnose schizophrenia in plasma samples.

Keywords

cholic acidtaurochenodeoxycholic acidtaurodeoxycholic acidschizophreniabiomarker
Type
Short Communication
Information
Acta Neuropsychiatrica , Volume 33 , Issue 1 , February 2021 , pp. 51 - 54
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Copyright
© Scandinavian College of Neuropsychopharmacology 2020

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References

Ackerman, HD and Gerhard, GS (2016) Bile acids in neurodegenerative disorders. Frontiers in Aging Neuroscience 8, 263.CrossRefGoogle ScholarPubMed
Cheng, L, Huang, C and Chen, Z (2019) Tauroursodeoxycholic acid ameliorates lipopolysaccharide-induced depression like behavior in mice via the inhibition of neuroinflammation and oxido-nitrosative stress. Pharmacology 103(1–2), 93–100.CrossRefGoogle ScholarPubMed
Chiang, JY (2013) Bile acid metabolism and signaling. Comprehensive Physiology 3(3), 1191–212.Google ScholarPubMed
Girgis, RR, Kumar, SS and Brown, AS (2014) The cytokine model of schizophrenia: emerging therapeutic strategies. Biological Psychiatry 75(4), 292–299.CrossRefGoogle ScholarPubMed
Huang, F, Wang, T, Lan, Y, Yang, L, Pan, W, Zhu, Y, Lv, B, Wei, Y, Shi, H, Wu, H, Zhang, B, Wang, J, Duan, X, Hu, Z and Wu, X (2015) Deletion of mouse FXR gene disturbs multiple neurotransmitter systems and alters neurobehavior. Frontiers in Behavioral Neuroscience 9, 70.CrossRefGoogle ScholarPubMed
Kealy, J, Greene, C and Campbell, M (2020) Blood-brain barrier regulation in psychiatric disorders. Neuroscience Letters 726, 133664.CrossRefGoogle ScholarPubMed
Long, SL, Gahan, CGM and Joyce, SA (2017) Interactions between gut bacteria and bile in health and disease. Molecular Aspects of Medicine 56, 54–65.CrossRefGoogle ScholarPubMed
Lu, X, Yang, RR, Zhang, JL, Wang, P, Gong, Y, Hu, WF, Wu, Y, Gao, MH and Huang, C (2018) Tauroursodeoxycholic acid produces antidepressant-like effects in a chronic unpredictable stress model of depression via attenuation of neuroinflammation, oxido-nitrosative stress, and endoplasmic reticulum stress. Fundamental & Clinical Pharmacology 32(4), 363–377.CrossRefGoogle Scholar
Manley, S and Ding, W (2015) Role of farnesoid X receptor and bile acids in alcoholic liver disease. Acta Pharmaceutica Sinica B 5(2), 158–167.CrossRefGoogle ScholarPubMed
Mano, N, Goto, T, Uchida, M, Nishimura, K, Ando, M, Kobayashi, N and Goto, J (2004) Presence of protein-bound unconjugated bile acids in the cytoplasmic fraction of rat brain. Journal of Lipid Research 45(2), 295–300.CrossRefGoogle ScholarPubMed
Marksteiner, J, Blasko, I, Kemmler, G, Koal, T and Humpel, C (2018) Bile acid quantification of 20 plasma metabolites identifies lithocholic acid as a putative biomarker in Alzheimer’s disease. Metabolomics 14(1), 1.CrossRefGoogle ScholarPubMed
Mirnics, K, Middleton, FA, Marquez, A, Lewis, DA and Levitt, P (2000) Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Neuron 28(1), 53–67.CrossRefGoogle ScholarPubMed
Nguyen, TT, Kosciolek, T, Maldonado, Y, Daly, RE, Martin, AS, McDonald, D, Knight, R and Jeste, DV (2019) Differences in gut microbiome composition between persons with chronic schizophrenia and healthy comparison subjects. Schizophrenia Research 204, 23–29.CrossRefGoogle ScholarPubMed
Paul, R, Choudhury, A, Kumar, S, Giri, A, Sandhir, R and Borah, A (2017) Cholesterol contributes to dopamine-neuronal loss in MPTP mouse model of Parkinson’s disease: involvement of mitochondrial dysfunctions and oxidative stress. PLoS One 12(2), e0171285.CrossRefGoogle ScholarPubMed
Perez-Santiago, J, Diez-Alarcia, R, Callado, LF, Zhang, JX, Chana, G, White, CH, Glatt, SJ, Tsuang, MT, Everall, IP, Meana, JJ and Woelk, CH (2012) A combined analysis of microarray gene expression studies of the human prefrontal cortex identifies genes implicated in schizophrenia. Journal of Psychiatric Research 46(11), 1464–74.CrossRefGoogle Scholar
Pollak, TA, Drndarski, S, Stone, JM, David, AS, McGuire, P and Abbott, NJ (2018) The blood–brain barrier in psychosis. Lancet Psychiatry 5(1), 79–92.CrossRefGoogle ScholarPubMed
Ridlon, JM, Kang, DJ and Hylemon, PB (2006) Bile salt biotransformations by human intestinal bacteria. Journal of Lipid Research 47(2), 241–259.CrossRefGoogle ScholarPubMed
Schubring, SR, Fleischer, W, Lin, JS, Haas, HL and Sergeeva, OA (2012) The bile steroid chenodeoxycholate is a potent antagonist at NMDA and GABA(A) receptors. Neuroscience Letters 506(2), 322–326.CrossRefGoogle ScholarPubMed
Sipka, S and Bruckner, G (2014) The immunomodulatory role of bile acids. International Archives of Allergy and Immunology 165(1), 1–8.CrossRefGoogle ScholarPubMed
Wang, J, Xiong, AZ, Cheng, RR, Yang, L, Wang, ZT and Liu, SY (2018) Systematical analysis of multiple components in drainage bear bile powder from different sources. Zhongguo Zhong Yao Za Zhi 43(11), 2326–2332.Google ScholarPubMed
Weickert, CS, Weickert, TW, Pillai, A and Buckley, PF (2013) Biomarkers in schizophrenia: a brief conceptual consideration. Disease Markers 35(1), 3–9.CrossRefGoogle ScholarPubMed
Xie, G, Zhong, W, Li, H, Li, Q, Qiu, Y, Zheng, X, Chen, H, Zhao, X, Zhang, S, Zhou, Z, Zeisel, SH and Jia, W (2013) Alteration of bile acid metabolism in the rat induced by chronic ethanol consumption. FASEB Journal 27(9), 3583–3593.CrossRefGoogle ScholarPubMed
Yang, W, Shen, Z, Wen, S, Wang, W and Hu, M (2018) Mechanisms of multiple neurotransmitters in the effects of Lycopene on brain injury induced by Hyperlipidemia. Lipids in Health and Disease 17(1), 13.CrossRefGoogle ScholarPubMed
Zheng, X, Chen, T, Zhao, A, Wang, X, Xie, G, Huang, F, Liu, J, Zhao, Q, Wang, S, Wang, C, Zhou, M, Panee, J, He, Z and Jia, W (2016) The brain metabolome of male rats across the lifespan. Scientific Reports 6, 24125.CrossRefGoogle ScholarPubMed
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