Hostname: page-component-76fb5796d-skm99 Total loading time: 0 Render date: 2024-04-26T18:42:30.905Z Has data issue: false hasContentIssue false
  • English
  • Français

Changes in immune and endocrine systems in posttraumatic stress disorder – prospective study

Published online by Cambridge University Press:  24 June 2014

Anđelko Vidović ,
Maja Vilibić ,
Ante Sabioncello ,
Katja Gotovac ,
Sabina Rabatić ,
Vera Folnegović-Šmalc  and
Dragan Dekaris
Anđelko Vidović
Affiliation:
University Hospital Dubrava, Department of Psychiatry, Referral Centre for the Stress-Related Disorders, Zagreb, Croatia
Maja Vilibić
Affiliation:
University Department of Psychiatry, Psychiatric Hospital Vrapce, Zagreb, Croatia
Ante Sabioncello
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Katja Gotovac
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Sabina Rabatić
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Vera Folnegović-Šmalc
Affiliation:
University Department of Psychiatry, Psychiatric Hospital Vrapce, Zagreb, Croatia
Dragan Dekaris
Affiliation:
Department for Cellular Immunology, Institute of Immunology, Zagreb, Croatia
Get access Rights & Permissions [Opens in a new window]

Abstract:

Introduction and aim: Posttraumatic stress disorder (PTSD) is associated with increased medical morbidity, particularly from the autoimmune and cardiovascular diseases. Changes in the endocrine and immune system are key mediators in this process. The aim of our study was to investigate weather hormones (cortisol and prolactin), proinflammatory cytokines (interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α)), components of HPA-axis (lymphocyte expression of glucocorticoid receptor (GR)), immune function (natural killer cell cytotoxicity) and peripheral blood percentages of various lymphocyte subpopulations (T cells, helper T cells, cytotoxic T cells, B cells and natural killer cells) change in patients with posttraumatic stress disorder over time.

Type
Psychoimmunology Symposium: The Impact of Dysfunctional Endocrine and Immune Systems on Psychiatric Disorders
Information
Acta Neuropsychiatrica , Volume 21 , Issue S2: Special Issue: Abstracts of 49th Neuropsychiatric Pula Congress, 17-20 June 2009, Pula, Croatia , June 2009 , pp. 46 - 50
Copyright
Copyright © 2009 John Wiley & Sons A/S

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

References:

1.Boscarino, JA. Posttraumatic stress disorder and physical illness: Results from clinical and epidemiologic studies. Annals of the New York Academy of Sciences 2004;1032:141–153.CrossRefGoogle ScholarPubMed
2.Wong, CM. Post-traumatic stress disorder: advances in psy-choneuroimmunology. Psychiatric Clinics of North America 2002;25:369–383.CrossRefGoogle Scholar
3.de Kloet, CS, Vermetten, E, Geuze, E, Kavelaars, A, Heijnen, CJ, & Westenberg, HGM. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. Journal of Psychiatric Research 2006;40:550–567.CrossRefGoogle ScholarPubMed
4.Gotovac, K, Sabioncello, A, Rabatic, S, Berki, T, & Dekaris, D. Flow cytometric determination of glucocorticoid receptor (GCR) expression in lymphocyte subpopulations: lower quantity of GCR in patients with post-traumatic stress disorder (PTSD). Clinical and Experimental Immunology 2003;131:335–339.CrossRefGoogle ScholarPubMed
5.Wilson, SN, van der Kolk, B, Burbridge, J, Fisler, R, & Kradin, R. Phenotype of blood lymphocytes in PTSD suggests chronic immune activation. Psychosomatics 1999;40:222–225.CrossRefGoogle ScholarPubMed
6.Boscarino, JA, & Chang, J. Higher abnormal leukocyte and lymphocyte counts 20 years after exposure to severe stress: research and clinical implications. Psychosomatic Medicine 1999;61:378–386.CrossRefGoogle ScholarPubMed
7.Laudenslager, ML, Aasal, R, Adler, L, Berger, CL, Montgomery, PT, Sandberg, E, Wahlberg, LJ, Wilkins, RT, Zweig, L, & Reite, ML. Elevated cytotoxicity in combat veterans with long-term post-traumatic stress disorder: preliminary observations. Brain, Behavior, and Immunity 1998;12:74–79.CrossRefGoogle ScholarPubMed
8.Timonen, T, Saksela, E, Ranki, A, & Hayry, P. Fractionation, morphological and functional characterization of effector cells responsible for human natural killer activity against cell-line targets. Cellular Immunology 1979;48:133–148.CrossRefGoogle ScholarPubMed
9.Berki, T, Kumáinovics, G, Kumáinovics, A, Falus, A, Ujhelyi, E, Németh, P. Production and flow cytometric application of a monoclonal anti-glucocorticoid receptor antibody. Journal of Immunological Methods 1998;214:19–27.CrossRefGoogle ScholarPubMed
10.Benjamini, Y, & Hochberg, Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society: Series B (Statistical Methodology) 1995;57:289–300.Google Scholar
11.Yehuda, R. Post-traumatic stress disorder. The New England Journal of Medicine 2002;346:108–114.CrossRefGoogle ScholarPubMed
12.Webster Marketon, JI, & Glaser, R. Stress hormones and immune function. Cellular Immunology 2008; In Press, Corrected Proof.Google Scholar
13.Sabioncello, A, Kocijan-Hercigonja, D, Rabatic, S, Tomasic, J, Jeren, T, Matijevic, L, Rijavec, M, & Dekaris, D. Immune, endocrine, and psychological responses in civilians displaced by war. Psychosomatic Medicine 2000;62:502–508.CrossRefGoogle ScholarPubMed
14.Olff, M, Guzelcan, Y, de Vries, GJ, Assies, J, & Gersons, BP.HPA- and HPT-axis alterations in chronic posttraumatic stress disorder. Psychoneuroendocrinology 2006;31:1220–1230.CrossRefGoogle ScholarPubMed
15.Song, Y, Zhou, D, & Wang, X. Increased serum cortisol and growth hormone levels in earthquake survivors with PTSD or subclinical PTSD. Psychoneuroendocrinology 2008;33:1155–1159.CrossRefGoogle ScholarPubMed
16.Sun, R, Li, AL, Wei, HM, & Tian, ZG.Expression of prolactin receptor and response to prolactin stimulation of human NK cell lines. Cell Research 2004;14:67–73.CrossRefGoogle ScholarPubMed
17.von Kanel, R, Hepp, U, Kraemer, B, Traber, R, Keel, M, Mica, L, & Schnyder, U. Evidence for low-grade systemic proinflammatory activity in patients with posttraumatic stress disorder. Journal of Psychiatric Research 2007;41:744–752.CrossRefGoogle ScholarPubMed
18.Sutherland, AG, Alexander, DA, & Hutchison, JD.Disturbance of pro-inflammatory cytokines in post-traumatic psychopa-thology. Cytokine 2003;24:219–225.CrossRefGoogle Scholar
19.Miller, RJ, Sutherland, AG, Hutchison, JD, & Alexander, DA.C-reactive protein and interleukin 6 receptor in post-traumatic stress disorder: a pilot study. Cytokine 2001;13:253–255.CrossRefGoogle ScholarPubMed
20.Maes, M, Lin, AH, Delmeire, L, Van Gastel, A, Kenis, G, De Jongh, R, & Bosmans, E. Elevated serum interleukin-6 (IL-6) and IL-6 receptor concentrations in posttraumatic stress disorder following accidental man-made traumatic events. Biol Psychiatry 1999;45:833–839.CrossRefGoogle ScholarPubMed
21.Baker, DG, Ekhator, NN, Kasckow, JW, Hill, KK, Zoumakis, E, Dashevsky, BA, Chrousos, GP, & Geracioti, Td Jr.Plasma and cerebrospinal fluid interleukin-6 concentrations in posttrau-matic stress disorder. Neuroimmunomodulation 2001;9:209–217.CrossRefGoogle ScholarPubMed
22.Gander, ML, & Von Kanel, R. Myocardial infarction and post-traumatic stress disorder: Frequency, outcome, and atherosclerotic mechanisms. European Journal of Cardiovascular Prevention and Rehabilitation 2006;13:165–172.CrossRefGoogle ScholarPubMed
23.Watson, IP, Muller, HK, Jones, IH, & Bradley, AJ.Cellmediated immunity in combat veterans with post-traumatic stress disorder. Medical Journal of Australia 1993;159:513–516.CrossRefGoogle ScholarPubMed
24.Skarpa, I, Rubesa, G, Moro, L, Manestar, D, Petrovecki, M, & Rukavina, D. Changes of cytolytic cells and perforin expression in patients with posttraumatic stress disorder. Croatian Medical Journal 2001;42:551–555.Google ScholarPubMed
25.Ironson, G, Wynings, C, Schneiderman, N, Baum, A, Rodriguez, M, Greenwood, D, Benight, C, Antoni, M, LaPerriere, A, Huang, HS, Klimas, N, & Fletcher, MA.Posttraumatic stress symptoms, intrusive thoughts, loss, and immune function after Hurricane Andrew. Psychosomatic Medicine 1997;59:128–141.CrossRefGoogle ScholarPubMed
26.Mosnaim, AD, Wolf, ME, Maturana, P, Mosnaim, G, Puente, J, Kucuk, O, & Gilman-Sachs, A. In vitro studies of natural killer cell activity in post traumatic stress disorder patients. Response to methionine-enkephalin challenge. Immunopharmacology 1993;25:107–116.CrossRefGoogle ScholarPubMed
27.Segerstrom, SC, & Miller, GE.Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry. Psychological Bulletin 2004;130:601–630.CrossRefGoogle ScholarPubMed
28.Lauc G, Dabelić, Dumic, J, & Flogel, M. Stressin and natural killer cell activity in professional soldiers. Annals of the New York Academy of Sciences 1998;851:526–530.CrossRefGoogle ScholarPubMed