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BDNF-related mutations in major depressive disorder: a systematic review

Published online by Cambridge University Press:  22 August 2022

Johannes Hartig  and
Bogdan Nemeş Open the ORCID record for Bogdan Nemeş [Opens in a new window]
Johannes Hartig
Affiliation:
Department of Medical Psychology and Psychiatry, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, V. Babes St. No. 43, 400012 Cluj-Napoca, Romania Department of Neurology, University Hospital Wuerzburg, Josef-Schneider Street No. 11, 97080 Wuerzburg, Germany
Bogdan Nemeş*
Affiliation:
Department of Medical Psychology and Psychiatry, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, V. Babes St. No. 43, 400012 Cluj-Napoca, Romania
*
Author for correspondence: Bogdan Nemeş, Email: nemes.bogdan@umfcluj.ro
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Abstract

Objective:

A better understanding of the genetic, molecular and cellular mechanisms of brain-derived neurotrophic factor (BDNF) and its association with neuroplasticity could play a pivotal role in finding future therapeutic targets for novel drugs in major depressive disorder (MDD). Because there are conflicting results regarding the exact role of BDNF polymorphisms in MDD still, we set out to systematically review the current evidence regarding BDNF-related mutations in MDD.

Methods:

We conducted a keyword-guided search of the PubMed and Embase databases, using ‘BDNF’ or ‘brain-derived neurotrophic factor’ and ‘major depressive disorder’ and ’single-nucleotide polymorphism’. We included all publications in line with our exclusion and inclusion criteria that focused on BDNF-related mutations in the context of MDD.

Results:

Our search yielded 427 records in total. After screening and application of our eligibility criteria, 71 studies were included in final analysis. According to present overall scientific data, there is a possibly major pathophysiological role for BDNF neurotrophic systems to play in MDD. However, on the one hand, the synthesis of evidence makes clear that likely no overall association of BDNF-related mutations with MDD exists. On the other hand, it can be appreciated that solidifying evidence emerged on specific significant sub-conditions and stratifications based on various demographic, clinico-phenotypical and neuromorphological variables.

Conclusions:

Further research should elucidate specific BDNF-MDD associations based on demographic, clinico-phenotypical and neuromorphological variables. Furthermore, biomarker approaches, specifically combinatory ones, involving BDNF should be further investigated.

Keywords

brain-derived neurotrophic factormajor depressive disordersingle-nucleotide polymorphismsneuroplasticitybiomarkers
Type
Review Article
Information
Acta Neuropsychiatrica , Volume 35 , Issue 1 , February 2023 , pp. 5 - 26
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Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of Scandinavian College of Neuropsychopharmacology

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