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Serum total oxidant and antioxidant status in earthquake survivors with post-traumatic stress disorder

Published online by Cambridge University Press:  19 January 2015

Pinar Guzel Ozdemir*
Affiliation:
Medicine Faculty, Department of Psychiatry, Yuzuncu Yil University, Van, Turkey
İbrahim Kaplan
Affiliation:
Department of Biochemistry, Dicle University, Diyarbakir,Turkey
Cem Uysal
Affiliation:
Department of Forensic Medicine, Dicle University, Diyarbakir,Turkey
Mahmut Bulut
Affiliation:
Medicine Faculty, Department of Psychiatry, Dicle University, Diyarbakir, Turkey
Abdullah Atli
Affiliation:
Medicine Faculty, Department of Psychiatry, Dicle University, Diyarbakir, Turkey
Yasin Bez
Affiliation:
Medicine Faculty, Department of Psychiatry, Marmara University, İstanbul, Turkey
Mehmet Cemal Kaya
Affiliation:
Medicine Faculty, Department of Psychiatry, Dicle University, Diyarbakir, Turkey
Osman Ozdemir
Affiliation:
Medicine Faculty, Department of Psychiatry, Yuzuncu Yil University, Van, Turkey
*
Dr. Pinar Guzel Ozdemir, Medicine Faculty, Department of Psychiatry, Yuzuncu Yil University, Van 65200, Turkey. Tel: +905056179746; Fax: +904322167519; E-mail: pguzelozdemir@yahoo.com

Abstract

Objective

Oxidative stress has been shown to play an important role in the pathogenesis of post-traumatic stress disorder (PTSD). Although there are some studies on oxidative stress and PTSD, there is no report available on the serum total oxidant and antioxidant status in earthquake survivors with PTSD. Therefore, this study aimed to investigate the serum total oxidant and antioxidant status in earthquake survivors with chronic PTSD.

Material and Methods

The study group included 45 earthquake survivors with PTSD and 40 earthquake survivors without PTSD. The oxidative status was determined using the total antioxidant status and total oxidant status (TOS) measurements and by calculating the oxidative stress index (OSI).

Results

There were no statistically significant differences in the total antioxidant status, TOS, or OSI when comparing individuals with and without PTSD (all, p>0.05). There were no correlations between Clinician-Administered PTSD Scale scores and oxidant and antioxidant stress markers (all, p>0.05).

Conclusions

Our results suggest that the total oxidant and antioxidant status may not affect earthquake survivors with PTSD. This is the first study to evaluate the oxidative status in earthquake survivors with PTSD. Further studies are necessary to confirm these findings.

Type
Original Articles
Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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