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11-β hydroxysteroid type 1 knockout mice display an antidepressant-like phenotype in the forced swim test

Published online by Cambridge University Press:  24 September 2015

David A. Slattery ,
Doncho P. Uzunov  and
John F. Cryan
David A. Slattery*
Affiliation:
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Germany
Doncho P. Uzunov
Affiliation:
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland
John F. Cryan
Affiliation:
Neuroscience Research, Novartis Institutes for BioMedical Research, Novartis Pharma AG, Basel, Switzerland Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland APC Microbiome Institute, University College Cork, Cork, Ireland
*
David A. Slattery, Department of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany. Tel: +49 9419433049; Fax: +49 9419433052; E-mail: david.slattery@ur.de
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Abstract

Objective

11β-dehydroxysteroid dehydrogenase (HSD) types 1 and 2, enzymes are involved in the activation and inactivation of glucocorticoids in vivo, respectively. Indirect evidence implicates two enzymes in the aetiology of depression but no study has directly assessed the potential role of 11 β-HSD1 in animal tests.

Methods

We assessed 11 β-HSD1 knockout mice in the forced swim test (FST), tail suspension test (TST) and for locomotor activity.

Results

Genetic ablation of the 11β-HSD1 gene results in an antidepressant-like phenotype in the FST; the most widely utilised animal test of antidepressant activity, but not in the related TST. This may be related to the different biological substrates underlying these tests. The decreased FST immobility was not due to alterations in general activity.

Conclusions

Taken together these results suggest that 11β-HSD1 may play an important role in depression-related behaviours and further studies are necessary to fully characterise its role in such behaviour.

Keywords

corticosteroneknockoutmouse11β-dehydroxysteroid dehydrogenase
Type
Short Communications
Information
Acta Neuropsychiatrica , Volume 28 , Issue 1 , February 2016 , pp. 55 - 60
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Copyright
© Scandinavian College of Neuropsychopharmacology 2015 

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