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3 - Shock Management

Published online by Cambridge University Press:  18 January 2010

Richard P. Dutton
Affiliation:
Division of Trauma Anesthesiology, University of Maryland Medical Center, Baltimore, Maryland
Charles E. Smith
Affiliation:
Case Western Reserve University, Ohio
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Summary

Objectives

  1. Review the pathophysiology of shock in trauma.

  2. Discuss the diagnosis and treatment of shock in the trauma patient.

INTRODUCTION

Shock is a systemic disease caused by inadequate tissue oxygen delivery. Shock consists of both primary cellular injury due to hypoperfusion and the secondary inflammatory response that follows. Shock is a complication of many traumatic conditions and is the cause of up to half of all deaths from trauma: 40 percent due to acute hemorrhage and up to 10 percent due to multiple organ system failure long after the initial cause of shock has been controlled [1]. This chapter describes the mechanisms of injury that lead to shock, the pathophysiologic progression of shock, the way in which shock is diagnosed and monitored, and the ways in which shock is treated. The chapter concludes with specific recommendations for resuscitation today, and a brief survey of therapies that will be important in years to come.

PATHOPHYSIOLOGY

Shock may result from any traumatic or nontraumatic process that impairs the systemic delivery of oxygen, or that prevents its normal uptake and utilization. Table 3.1 lists the causes of shock in trauma patients, and although hemorrhage is the most common of these, it is by no means the only one. It is not unusual for shock to result from the combination of multiple triggers. Hemorrhage, tension pneumothorax, and cardiac contusion can all coexist in the patient with chest trauma, for example, with each contributing to systemic hypoperfusion.

Type
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Trauma Anesthesia , pp. 55 - 68
Publisher: Cambridge University Press
Print publication year: 2008

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References

Sauaia, A, Moore, FA, Moore, EE, et al. Epidemiology of trauma deaths: A reassessment. J Trauma 1995; 38: 185–93.CrossRefGoogle ScholarPubMed
Dutton RP. Management of traumatic shock. In Prough, DS, Fleisher, L, eds. Problems in Anesthesia: Trauma Care. London: Lippincott, Williams and Wilkins. Vol 13:3, 2002.Google Scholar
Peitzman AB. Hypovolemic shock. In Pinsky, MR, Dhainaut, JFA, ed. Pathophysiologic Foundations of Critical Care. Baltimore: Williams & Wilkins, 1993, pp 161–9.Google Scholar
Shires, GT, Cunningham, N, Baker, CRF, et al. Alterations in cellular membrane function during hemorrhagic shock in primates. Ann Surg 1972; 176: 288–95.CrossRefGoogle ScholarPubMed
Peitzman, AB, Billiar, TR, Harbrecht, BG, Kelly, E, Udekwu, AO, Simmons, R. Hemorrhagic shock. Curr Probl Surg 1995; 32(11): 929–1002.CrossRefGoogle ScholarPubMed
Honig, LS, Rosenberg, RN. Apoptosis and neurologic disease. Am J Med 2000; 108: 317–30.CrossRefGoogle ScholarPubMed
Collins, JA, The pathophysiology of hemorrhagic shock. Prog Clin Biol Res 1982; 108: 5–29.Google ScholarPubMed
Khalil, AA, Aziz, FA, Hall, JC. Reperfusion injury. Plast Reconstr Surg 2006; 117: 1024–33.CrossRefGoogle ScholarPubMed
Runciman, WB, Sjowronski, GA. Pathophysiology of haemorrhagic shock. Anaesth Intensive Care 1984; 12: 193–205.Google ScholarPubMed
Ba, ZF, Wang, P, Koo, DJ, Cioffi, WG, Bland, KI, Chaudry, IH. Alterations in tissue oxygen consumption and extraction after trauma and hemorrhagic shock. Crit Care Med 2000; 28: 2837–42.CrossRefGoogle ScholarPubMed
Dark, PM, Delooz, HH, Hillier, V, Hanson, J, Little, RA. Monitoring the circulatory responses of shocked patients during fluid resuscitation in the emergency department. Intensive Care Med 2000; 26: 173–9.CrossRefGoogle ScholarPubMed
Gann DS, Amaran JF. Endocrine and metabolic responses to injury. In Schwartz, SI, Shires, GT, Spencer, FC, ed. Principles of Surgery. New York: McGraw-Hill, 1989Google Scholar
Thorne, J, Blomquist, S, Elmer, O.Polymorphonuclear leukocyte sequestration in the lung and liver following soft tissue trauma: An in vivo study. J Trauma 1989; 29: 451–6.CrossRefGoogle ScholarPubMed
Fulton, RL, Raynor, AVS, Jones, C.Analysis of factors leading to posttraumatic pulmonary insufficiency. Ann Thorac Surg 1978; 25: 500–9.CrossRefGoogle ScholarPubMed
Demling, R, Lalonde, C, Saldinger, P, Knox, J.Multiple organ dysfunction in the surgical patient: Pathophysiology, prevention, and treatment. Curr Probl Surg 1993; 30: 345–424.CrossRefGoogle ScholarPubMed
Reilly, PM, Bulkley, GB.Vasoactive mediators and splanchnic perfusion. Crit Care Med 1993; 21: S55–68.CrossRefGoogle ScholarPubMed
Kutayli, ZN, Domingo, CB, Steinberg, SM.Intestinal failure. Curr Opin Anaesthesiol 2005; 18: 123–7.CrossRefGoogle ScholarPubMed
Maitra, SR, Geller, ER, Pan, W, Kennedy, PR, Higgins, LD.Altered cellular calcium regulation and hepatic glucose production during hemorrhagic shock. Circ Shock 1992; 38: 14–21.Google ScholarPubMed
Marcu, AC, Kielar, ND, Paccione, KE, Barbee, RW, Carter, H, Ivatury, RR, Dielgelmann, RF, Ward, KR, Loria, RM. Androstenetriol improves survival in a rodent model of traumatic shock. Resuscitation 2006 [Epub ahead of print] PMID16982126.
Chun, K, Zhang, J, Biewer, J, Ferguson, D, Clemens, MG. Microcirculatory failure determines lethal hepatocyte injury in ischemic-reperfused rat livers. Shock 1994, 1: 3–9.CrossRefGoogle ScholarPubMed
Redan, JA, Rush, BF, McCullogh, JN, et al. Organ distribution of radiolabeled enteric Escherichia coli during and after hemorrhagic shock. Ann Surg 1990; 211: 663–8.CrossRefGoogle ScholarPubMed
Mullins RJ. Management of shock. In Mattox KL, Feliciano DV, Moore EE, ed. Trauma, 4th edition. New York: McGraw-Hill, 2000.
Pedowitz, RA, Gershuni, DH, Schmidt, AH, Friden, J, Rydevik, BL, Hargens, AR. Muscle injury induced beneath and distal to a pneumatic tourniquet: A quantitative animal study of effects of tourniquet pressure and duration. J Hand Surg [Am] 1991; 16: 610–21.CrossRefGoogle ScholarPubMed
Dutton RP. Pathophysiology of traumatic shock. In Smith, CE, Rosenberg, AD, Grande, CM, ed. Massive Transfusion and Control of Hemorrhage in the Trauma Patient. Semin Anesth Perioperative Med Pain 2001; 20: 7–10.Google Scholar
Moore, EE. Staged laparotomy for the hypothermia, acidosis, coagulopathy syndrome. Am J Surg 1996; 72: 405.CrossRefGoogle Scholar
Choileain, Ni N, Redmond, HP.The immunological consequences of injury. Surgeon 2006; 4: 23–31.CrossRefGoogle Scholar
Hildebrand, F, Pape, HC, Griensven, M, Meier, S, Hasenkamp, S, Krettek, C, Stuhrmann, M.Genetic predisposition for a compromised immune system after multiple trauma. Shock 2005; 24: 518–22.CrossRefGoogle ScholarPubMed
Committee on Trauma, American College of Surgeons. Advanced Trauma Life Support Program for Doctors. Chicago: American College of Surgeons, 1997.
Davis, JW, Davis, IC, Bennink, LD, Bilello, JF, Kaups, KL, Parks, SN.Automated blood pressure measurements accurate in trauma patients?J Trauma 2003; 55: 860–3.CrossRefGoogle ScholarPubMed
Demetriades, D, Chan, LS, Bhasin, P. Relative bradycardia in patients with traumatic hypotension. J Trauma 1998; 45: 534–9.CrossRefGoogle ScholarPubMed
Abramson, D, Scalea, TM, Hitchcock, et al. Lactate clearance and survival following injury. J Trauma 1993; 35: 584–8.CrossRefGoogle ScholarPubMed
Blow, O, Magliore, L, Claridge, JA, et al: The golden hour and the silver day: Detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma 1999; 47: 964–9.CrossRefGoogle ScholarPubMed
Scalea, TM, Hartnett, RW, Duncan, AO, Atweh, NA, Phillips, TF, Sclafani, SJ, Fuortes, M, Shaftan, GW.Central venous oxygen saturation: A useful clinical tool in trauma patients. J Trauma 1990; 30: 1539–43.CrossRefGoogle ScholarPubMed
McKinley, BA, Butler, BD.Comparison of skeletal muscle PO2, PCO2, and pH with gastric tonometric P(CO2) and pH in hemorrhagic shock. Crit Care Med 1999; 27: 1869–77.CrossRefGoogle ScholarPubMed
Weil, MH, Nadagawa, Y, Tang, W, et al. Sublingual capnometry: a new noninvasive measurement for diagnosis and quantification of severity of circulatory shock. Crit Care Med 1999; 27: 1225–9.CrossRefGoogle Scholar
Puyana, JC, Soller, BR, Zhang, SB, Heard, SO.Continuous measurement of gut pH with near-infrared spectroscopy during hemorrhagic shock. J Trauma 1999; 46: 9–14.CrossRefGoogle ScholarPubMed
Albin, MS, White, RJ.Epidemiology, physiopathology and experimental therapeutics of acute spinal injury. Crit Care Clin 1987; 3: 441–52.CrossRefGoogle Scholar
Scalea, TM, Henry, SM; Assessment and initial management in the trauma patient. Probl Anesth 2001; 13: 271–8.Google Scholar
Rozycki, GS.Abdominal ultrasonography in trauma. Surg Clin N Am 1995; 75: 175–91.CrossRefGoogle ScholarPubMed
Dutton RP, McCunn M. Anesthesia for trauma. In Miller, RD, ed. Miller's Anesthesia, 6th edition. Philadelphia: Elsevier Churchill Livingstone, 2005, pp 2451–95.Google Scholar
Shaftan, GW, Chiu, C, Dennis, C, Harris, B.Fundamentals of physiologic control of arterial hemorrhage. Surgery 1965; 58: 851–6.Google ScholarPubMed
Stern, A, Dronen, SC, Birrer, P, Wang, X.Effect of blood pressure on haemorrhagic volume in a near-fatal haemorrhage model incorporating a vascular injury. Ann Emerg Med 1993; 22: 155–63.CrossRefGoogle Scholar
Shoemaker, WC, Peitzman, AB, Bellamy, R, et al. Resuscitation from severe hemorrhage. Crit Care Med 1996; 24: S12–23.CrossRefGoogle ScholarPubMed
Bickell, WH, Wall, MJ, Pepe, PE, et al. Immediate versus delayed resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med 1994; 331: 1105–9.CrossRefGoogle ScholarPubMed
Dutton, RP, Mackenzie, CF, Scalea, TM. Hypotensive resuscitation during active hemorrhage: Impact on in-hospital mortality. J Trauma 2002; 52: 1141–6.CrossRefGoogle ScholarPubMed
Dutton, RP, Shih, D, Edelman, BB, Hess, JR, Scalea, TM.Safety of uncrossmatched Type-O red cells for resuscitation from hemorrhagic shock. J Trauma 2005; 59: 1445–9.CrossRefGoogle ScholarPubMed
Fries, D, Innerhofer, P, Schobersberger, W.Coagulation management in trauma patients. Curr Opin Anaesthesiol 2002; 15: 217–23.CrossRefGoogle ScholarPubMed
Armand, R, Hess, JR.Treating coagulopathy in trauma patients. Transfus Med Rev 2003; 17: 223–31.CrossRefGoogle ScholarPubMed
Kauvar, DS, Holcomb, JB, Norris, GC, Hess, JR.Fresh whole blood transfusion: A controversial military practice. J Trauma 2006; 61: 181–4.CrossRefGoogle ScholarPubMed
Stein, DM, Dutton, RP.Uses of recombinant factor VIIa in trauma. Curr Opin Crit Care 2004; 10: 520–8.CrossRefGoogle ScholarPubMed
McGee, DC, Gould, MK.Preventing complications of central venous catheterization. N Engl J Med 2003; 348: 1123–33.CrossRefGoogle ScholarPubMed
Dutton RP. Hypothermia and hemorrhage. In Speiss, B, Shander, A, ed. Perioperative Transfusion Medicine. Philadelphia: Lippincott, Williams & Wilkins, 2006, pp 481–6.Google Scholar
Moeng, MS, Loveland, JA, Boffard, KD.Damage control: Beyond the limits of the abdominal cavity. A review. TraumaCare 2005; 15: 197–201.Google Scholar
McCunn, M.Mechanical ventilation: Weapon of mass destruction or tool for liberation?Crit Care Med 2003; 31: 974–6.CrossRefGoogle ScholarPubMed
DuBose, TD.Hyperkalemic hyperchloremic metabolic acidosis: Pathophysiologic insights. Kidney Int 1997; 51: 591–602.CrossRefGoogle ScholarPubMed
Laird, AM, Miller, PR, Kilgo, PD, Meredith, JW, Chang, MC.Relationship of early hyperglycemia to mortality in trauma patients. J Trauma 2004; 56: 1058–62.CrossRefGoogle ScholarPubMed
Sung, J, Bochicchio, GV, Joshi, M, Bochicchio, K, Tracy, K, Scalea, TM.Admission hyperglycemia is predictive of outcome in critically ill trauma patients. J Trauma 2005; 59: 80–3.CrossRefGoogle ScholarPubMed
Ely, EW, Bernard, GR, Vincent, JL.Activated protein C for severe sepsis. N Engl J Med 2002; 347: 1035–6.CrossRefGoogle ScholarPubMed
Chestnut, RM, Marshall, LF, Klauber, MR, et al. The role of secondary brain injury in determining outcome from severe head injury. J Trauma 1993; 134: 216–22.CrossRefGoogle Scholar
Novak, L, Shackford, SR, Bourguignon, P, Nichols, P, Buckingham, S, Osler, T, Sartorelli, K.Comparison of standard and alternative prehospital resuscitation in uncontrolled hemorrhagic shock and head injury. J Trauma 1999; 47: 834–44.CrossRefGoogle ScholarPubMed

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  • Shock Management
    • By Richard P. Dutton, Division of Trauma Anesthesiology, University of Maryland Medical Center, Baltimore, Maryland
  • Edited by Charles E. Smith, Case Western Reserve University, Ohio
  • Book: Trauma Anesthesia
  • Online publication: 18 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511547447.006
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  • Shock Management
    • By Richard P. Dutton, Division of Trauma Anesthesiology, University of Maryland Medical Center, Baltimore, Maryland
  • Edited by Charles E. Smith, Case Western Reserve University, Ohio
  • Book: Trauma Anesthesia
  • Online publication: 18 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511547447.006
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Shock Management
    • By Richard P. Dutton, Division of Trauma Anesthesiology, University of Maryland Medical Center, Baltimore, Maryland
  • Edited by Charles E. Smith, Case Western Reserve University, Ohio
  • Book: Trauma Anesthesia
  • Online publication: 18 January 2010
  • Chapter DOI: https://doi.org/10.1017/CBO9780511547447.006
Available formats
×