This chapter examines the important cultural role played by early modern sermons in refining and developing the meaning of sympathy. The chapter begins by exploring how metaphors and concepts involving the human and social body were appropriated by religious writers in the 1580s, including Edwin Sandys, John Udall, and Christopher Hooke. It then explores a particular sermon by William James from 1589 that uses the term sympathy to describe a mutual suffering, in which James seeks to unite his listeners whilst excluding those of a different religious or political persuasion. The chapter goes on to argue that, by the mid-1590s, preachers such as Henry Holland were using the term to describe an active and imaginative engagement with the other, in ways that recall several contemporaneous dramatic works – including Shakespeare’s Romeo and Juliet (c. 1595). Finally, it examines Thomas Wright’s The Passions of the Minde in Generall (1604) and proposes that these questions about the performance and representation of sympathy recur across Protestant and Catholic cultures.