Book contents
- Frontmatter
- Contents
- List of contributors
- Foreword
- Section I Basic sciences
- Section II Anaesthesia and peri-operative care for surgical specialties
- Section III At a glance
- Chapter 22 Scoring systems
- Chapter 23 Modes of mechanical ventilation
- Chapter 24 Fluids
- Chapter 25 Coagulation
- Chapter 26 Pre-operative echocardiography
- Chapter 27 Common drugs and doses
- Chapter 28 Physiology and risk in special circumstances
- Chapter 29 Medicolegal aspects of consent
- Chapter 30 Nerve injury
- Chapter 31 Pre-operative investigations
- Chapter 32 Enhanced recovery
- Chapter 33 Post-operative cognitive dysfunction
- List of abbreviations
- Index
Chapter 25 - Coagulation
Published online by Cambridge University Press: 05 July 2014
- Frontmatter
- Contents
- List of contributors
- Foreword
- Section I Basic sciences
- Section II Anaesthesia and peri-operative care for surgical specialties
- Section III At a glance
- Chapter 22 Scoring systems
- Chapter 23 Modes of mechanical ventilation
- Chapter 24 Fluids
- Chapter 25 Coagulation
- Chapter 26 Pre-operative echocardiography
- Chapter 27 Common drugs and doses
- Chapter 28 Physiology and risk in special circumstances
- Chapter 29 Medicolegal aspects of consent
- Chapter 30 Nerve injury
- Chapter 31 Pre-operative investigations
- Chapter 32 Enhanced recovery
- Chapter 33 Post-operative cognitive dysfunction
- List of abbreviations
- Index
Summary
Methods used to aid clot formation
Agents derived from blood products
Fresh Frozen Plasma (FFP)
Contains factors II, V, VII, IX, and XI: useful in acute active haemorrhage.
Cryoprecipitate
Replacement of fibrinogen in the acutely bleeding patient (especially in DIC – fibrinogen consumption): also useful for von Willebrands, and factor VIII and XIII replacement.
Prothrombin complex concentrate – Octaplex, Beriplex
Used for rapid reversal of warfarin anticoagulation pre-operatively or during haemorrhage. Derived from human plasma and contains factors II, VII, IX and X. Effects last six to 12 hours.
Recombinant Factor VIIa
Originally used in the treatment of haemophilia, but use has transferred into the management of major haemorrhage from trauma and surgery.
It enhances thrombin generation on platelet surface at the site of injury, thereby inducing clot formation via tight fibrin plug and haemostasis.
Drugs
Vitamin K
Useful for reversal of warfarin but it has a slow onset and long duration of action, which can cause problems in those patients that require anticoagulation after major bleeding has been terminated.
Tranexamic acid
Antifibrinolytic, which competitively inhibits activation of plasminogen, reducing conversion of plasminogen to plasmin – the enzyme that breaks down clots.
- Type
- Chapter
- Information
- A Surgeon's Guide to Anaesthesia and Peri-operative Care , pp. 277 - 280Publisher: Cambridge University PressPrint publication year: 2014
- 1
- Cited by