Book contents
- Frontmatter
- Dedication
- Contents
- Contents
- Contributors
- Foreword to the First Edition
- Preface to the Sixth Edition
- Acknowledgements
- Chapter 1 The normal lung: histology, embryology, development, aging and function
- Chapter 2 Lung specimen handling and practical considerations
- Chapter 3 Congenital abnormalities and pediatric lung diseases, including neoplasms
- Chapter 4 Pulmonary bacterial infections
- Chapter 5 Pulmonary viral infections
- Chapter 6 Pulmonary mycobacterial infections
- Chapter 7 Pulmonary mycotic infections
- Chapter 8 Pulmonary parasitic infections
- Chapter 9 Acute lung injury
- Chapter 10 Interstitial lung diseases
- Chapter 11 Metabolic and inherited connective tissue disorders involving the lung
- Chapter 12 Hypersensitivity pneumonitis
- Chapter 13 Sarcoidosis
- Chapter 14 Occupational lung disease
- Chapter 15 Eosinophilic lung disease
- Chapter 16 Drug- and therapy-induced lung injury
- Chapter 17 Chronic obstructive pulmonary disease and diseases of the airways
- Chapter 18 Pulmonary vascular pathology
- Chapter 19 Pulmonary vasculitis and pulmonary hemorrhage syndromes
- Chapter 20 The pathology of lung transplantation
- Chapter 21 The lungs in connective tissue disease
- Chapter 22 Benign epithelial neoplasms and tumor-like proliferations of the lung
- Chapter 23 Pulmonary pre-invasive disease
- Chapter 24 Epidemiological and clinical aspects of lung cancer
- Chapter 25 Lung cancer staging
- Chapter 26 Immunohistochemistry in the diagnosis of pulmonary tumors
- Chapter 27 Adenocarcinoma of the lung
- Chapter 28 Squamous cell carcinoma of the lung
- Chapter 29 Large cell carcinoma and adenosquamous carcinoma of the lung
- Chapter 30 Salivary gland neoplasms of the lung
- Chapter 31 Neuroendocrine tumors and other neuroendocrine proliferations of the lung
- Chapter 32 Sarcomatoid carcinomas and variants
- Chapter 33 Mesenchymal and miscellaneous neoplasms
- Chapter 34 Pulmonary lymphoproliferative diseases
- Chapter 35 Metastases involving the lungs
- Chapter 36 Diseases of the pleura
- Index
- References
Chapter 22 - Benign epithelial neoplasms and tumor-like proliferations of the lung
Published online by Cambridge University Press: 05 June 2014
- Frontmatter
- Dedication
- Contents
- Contents
- Contributors
- Foreword to the First Edition
- Preface to the Sixth Edition
- Acknowledgements
- Chapter 1 The normal lung: histology, embryology, development, aging and function
- Chapter 2 Lung specimen handling and practical considerations
- Chapter 3 Congenital abnormalities and pediatric lung diseases, including neoplasms
- Chapter 4 Pulmonary bacterial infections
- Chapter 5 Pulmonary viral infections
- Chapter 6 Pulmonary mycobacterial infections
- Chapter 7 Pulmonary mycotic infections
- Chapter 8 Pulmonary parasitic infections
- Chapter 9 Acute lung injury
- Chapter 10 Interstitial lung diseases
- Chapter 11 Metabolic and inherited connective tissue disorders involving the lung
- Chapter 12 Hypersensitivity pneumonitis
- Chapter 13 Sarcoidosis
- Chapter 14 Occupational lung disease
- Chapter 15 Eosinophilic lung disease
- Chapter 16 Drug- and therapy-induced lung injury
- Chapter 17 Chronic obstructive pulmonary disease and diseases of the airways
- Chapter 18 Pulmonary vascular pathology
- Chapter 19 Pulmonary vasculitis and pulmonary hemorrhage syndromes
- Chapter 20 The pathology of lung transplantation
- Chapter 21 The lungs in connective tissue disease
- Chapter 22 Benign epithelial neoplasms and tumor-like proliferations of the lung
- Chapter 23 Pulmonary pre-invasive disease
- Chapter 24 Epidemiological and clinical aspects of lung cancer
- Chapter 25 Lung cancer staging
- Chapter 26 Immunohistochemistry in the diagnosis of pulmonary tumors
- Chapter 27 Adenocarcinoma of the lung
- Chapter 28 Squamous cell carcinoma of the lung
- Chapter 29 Large cell carcinoma and adenosquamous carcinoma of the lung
- Chapter 30 Salivary gland neoplasms of the lung
- Chapter 31 Neuroendocrine tumors and other neuroendocrine proliferations of the lung
- Chapter 32 Sarcomatoid carcinomas and variants
- Chapter 33 Mesenchymal and miscellaneous neoplasms
- Chapter 34 Pulmonary lymphoproliferative diseases
- Chapter 35 Metastases involving the lungs
- Chapter 36 Diseases of the pleura
- Index
- References
Summary
Introduction
Despite the tremendous number of malignant epithelial lung neoplasms worldwide, benign epithelial tumors and tumor-like lesions are rare. Endobronchial and peripheral parenchymal lesions are both seen. While voluminous epidemiological and molecular information is lacking, lesional morphologies are well described. Recognizing these lesions as benign is of paramount importance.
Bronchial inflammatory polyps
Introduction
Although the upper respiratory tract is a common location for inflammatory polyps, for unknown reasons these non-neoplastic lesions are exceedingly rare in major bronchi or smaller-caliber airways. The World Health Organization (WHO) prefers the term bronchial inflammatory polyp to emphasize the non-neoplastic nature of the lesion. Fibroepithelial polyp, though commonly used, is a misnomer since the lesion has no true epithelial component. Nevertheless, the lesion is best discussed in this chapter along with true benign epithelial tumors.
Classification, cell of origin, pathogenesis and etiology
Inflammatory polyps are regenerative lesions representing exuberant, non-resolving, localized tissue repair following injury. As in all organs, if regeneration does not follow injury, a fibroproliferative tissue response patches the wound. This repair relies on tissue fibroblasts and vascular endothelial cells, which form granulation tissue. The leaky blood vessels allow protein and red cell extravasation into the extravascular space and form a scaffold for fibroblasts and subsequent fibrillar collagen deposition. In most instances a scar forms but in some situations the granulation tissue persists. Inflammatory polyps are an example of this persistent exuberant tissue repair process, following mucosal erosion or ulceration. The bronchial mucosa is susceptible to many insults and immunological, infectious and environmental causes abound. Neonates, infants and children are particularly susceptible to prolonged intubations, mechanical ventilation and suction while infections, reflux and aspiration as well as thermal and chemical inhalation injuries are common factors in adults (Table 1). Of note, polyps may develop months after a respiratory problem, such as smoke inhalation, chemical inhalation or aspiration.
- Type
- Chapter
- Information
- Spencer's Pathology of the Lung , pp. 847 - 888Publisher: Cambridge University PressPrint publication year: 2000
References
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