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Chapter 8 - Disinfection and Sterilization in Healthcare Facilities

from Section 2 - Infection Prevention Basics

Published online by Cambridge University Press:  02 April 2018

Ebbing Lautenbach
Affiliation:
University of Pennsylvania School of Medicine
Preeti N. Malani
Affiliation:
University of Michigan, Ann Arbor
Keith F. Woeltje
Affiliation:
Washington University School of Medicine, St Louis
Jennifer H. Han
Affiliation:
University of Pennsylvania School of Medicine
Emily K. Shuman
Affiliation:
University of Michigan, Ann Arbor
Jonas Marschall
Affiliation:
Washington University School of Medicine, St Louis
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References

Centers for Disease Control and Prevention. National hospital discharge survey: 2010 table, Procedures by selected patient characteristics-number by procedure category and age. 2010.Google Scholar
Peery, AF DE, Lund, J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterol 2012;143: 11791187.Google Scholar
Epstein, L, Hunter, JC, Arwady, MA, et al. New Delhi metallo-beta-lactamase-producing carbapenem-resistant Escherichia coli associated with exposure to duodenoscopes. JAMA 2014;312: 14471455.Google Scholar
Wendorf, KA, Kay, M, Baliga, C, et al. Endoscopic retrograde cholangiopancreatography-associated AmpC Escherichia coli outbreak. Infect Control Hosp Epidemiol 2015;36: 634642.CrossRefGoogle ScholarPubMed
Ofstead, CL, Wetzler, HP, Snyder, AK, Horton, RA. Endoscope reprocessing methods: a prospective study on the impact of human factors and automation. Gastroenterol Nurs 2010;33: 304311.CrossRefGoogle ScholarPubMed
Kovaleva, J, Peters, FT, van der Mei, HC, Degener, JE. Transmission of infection by flexible gastrointestinal endoscopy and bronchoscopy. Clin Microbiol Rev 2013;26: 231254.CrossRefGoogle ScholarPubMed
Rutala, WA, Weber, DJ. How to assess risk of disease transmission to patients when there is a failure to follow recommended disinfection and sterilization guidelines. Infect Control Hosp Epidemiol 2007;28: 146155.Google Scholar
Weber, DJ, Rutala, WA. Lessons learned from outbreaks and pseudo-outbreaks associated with bronchoscopy. Infect Control Hosp Epidemiol 2012;33: 230234.Google Scholar
Centers for Disease Control and Prevention. Immediate need for healthcare facilities to review procedures for cleaning, disinfecting, and sterilizing reusable medical devices. http://emergency.cdc.gov/han/han00382.asp; 2015.Google Scholar
Rutala, WA, Weber, DJ. Disinfection, sterilization and control of hospital waste. In: Bennett, JE DR, Blaser, MJ, eds. Principles and Practice of Infectious Diseases. Philadelphia, PA: Elsevier Saunders; 2015: 3294–309.Google Scholar
Rutala, WA, Weber, DJ. Disinfection and sterilization: an overview. Am J Infect Control 2013;41: S25.Google Scholar
Rutala, WA, Weber, DJ. Cleaning, disinfection and sterilization. In: Grota, P, ed. APIC Text of Infection Control and Epidemiology. 4th ed. Washington, DC: Association for Professionals in Infection Control and Epidemiology, Inc.; 2014: 31.131.15.Google Scholar
Rutala, WA, Weber, DJ, HICPAC. Guideline for disinfection and sterilization in healthcare facilities, 2008. wwwcdc.gov/hicpac/pdf/guidelines/Disinfection_Nov_2008.pdf. Centers for Disease Control and Prevention, 2008.Google Scholar
Spaulding, EH. Chemical disinfection of medical and surgical materials. In: Lawrence, C, Block, S. S. ed. Disinfection, Sterilization, and Preservation. Philadelphia, PA: Lea & Febiger; 1968: 517531.Google Scholar
Sehulster, L, Chinn, RYW, Healthcare Infection Control Practices Advisory Committee. Guidelines for environmental infectin control in healthcare facilities. MMWR Morb Mortal Wkly Rep 2003;52: 144.Google Scholar
McDonnell, G, Burke, P. Disinfection: is it time to reconsider Spaulding? J Hosp Infect 2011;78: 163170.Google Scholar
Rutala, WA, Weber, DJ. Gastrointestinal endoscopes: a need to shift from disinfection to sterilization? JAMA 2014;312: 14051406.Google Scholar
Rutala, WA, Weber, DJ. ERCP scopes: what can we do to prevent infections? Infect Control Hosp Epidemiol 2015;36: 643648.Google Scholar
Food and Drug Administration. FDA-cleared sterilants and high level disinfectants with general claims for processing reusable medical and dental devices, March 2015. www.fdagov/MedicalDevices/DeviceRegulationandGuidance/ReprocessingofReusableMedicalDevices/ucm437347htm 2015.Google Scholar
Tosh, PK, Disbot, M, Duffy, JM, et al. Outbreak of Pseudomonas aeruginosa surgical site infections after arthroscopic procedures: Texas, 2009. Infect Control Hosp Epidemiol 2011;32: 11791186.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Microbial contamination on used surgical instruments. Infect Control Hosp Epidemiol 2014;35: 10681070.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Efficacy of a washer-disinfector in eliminating healthcare-associated pathogens from surgical instruments. Infect Control Hosp Epidemiol 2014;35: 883885.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Disinfection of a probe used in ultrasound-guided prostate biopsy. Infect Control Hosp Epidemiol 2007;28: 916919.Google Scholar
Rutala, WA GM, Sickbert-Bennett, EE. Effectiveness of a hydrogen peroxide mist (Trophon®) system in inactivating healthcare pathogens on surface and endocavitary probes. Infect Control Hosp Epidemiol; In press.Google Scholar
Weber, DJ, Rutala, WA. Role of environmental contamination in the transmission of vancomycin-resistant enterococci. Infect Control Hosp Epidemiol 1997;18: 306309.CrossRefGoogle ScholarPubMed
Weber, DJ, Rutala, WA, Miller, MB, Huslage, K, Sickbert-Bennett, E. Role of hospital surfaces in the transmission of emerging health care-associated pathogens: norovirus, Clostridium difficile, and Acinetobacter species. Am J Infect Control 2010;38:S25S33.Google Scholar
Schembre, DB. Infectious complications associated with gastrointestinal endoscopy. Gastrointest Endosc Clin N Am 2000;10: 215232.Google Scholar
Petersen, BT, Chennat, J, Cohen, J, et al. Multisociety guideline on reprocessing flexible GI endoscopes: 2011. Infect Control Hosp Epidemiol 2011;32: 527537.Google Scholar
Society of Gastroenterology Nurses and Associates I. Standards of infection control and reprocessing of flexible gastrointestinal endoscopes. Gastroenterol Nurs 2013;36: 293303.Google Scholar
Muscarella, LF. Risk of transmission of carbapenem-resistant Enterobacteriaceae and related “superbugs” during gastrointestinal endoscopy. World J Gastrointest Endosc 2014;6: 457474.Google Scholar
Ofstead, CL, Wetzler, HP, Doyle, EM, et al. Persistent contamination on colonoscopes and gastroscopes detected by biologic cultures and rapid indicators despite reprocessing performed in accordance with guidelines. Am J Infect Control 2015;43: 794801.CrossRefGoogle ScholarPubMed
Rutala, WA, Weber, DJ. FDA labeling requirements for disinfection of endoscopes: a counterpoint. Infect Control Hosp Epidemiol 1995;16: 231235.Google Scholar
Carbonne, A, Thiolet, JM, Fournier, S, et al. Control of a multi-hospital outbreak of KPC-producing Klebsiella pneumoniae type 2 in France, September to October 2009. Euro Surveill 2010;15.Google ScholarPubMed
Roberts, CG. Studies on the bioburden on medical devices and the importance of cleaning. In: Rutala, WA, ed. Disinfection, Sterilization and Antisepsis: Principles and Practices in Healthcare Facilities. Washington, DC: Association for Professionals in Infection Control and Epidemiology; 2000: 6369.Google Scholar
Alfa, MJ, Degagne, P, Olson, N. Worst-case soiling levels for patient-used flexible endoscopes before and after cleaning. Am J Infect Control 1999;27: 392401.CrossRefGoogle ScholarPubMed
Food and Drug Administration. Brief summary of the gastroeneterology and urology devices panel meeting, May 14–15, 2015. Food and Drug Administration.Google Scholar
Pajkos, A, Vickery, K, Cossart, Y. Is biofilm accumulation on endoscope tubing a contributor to the failure of cleaning and decontamination. J Hosp Infect 2004;58: 224.Google Scholar
Roberts, CG. The role of biofilms in reprocessing medical devices. In: Rutala, WA, ed. Disinfection, Sterilization and Antisepsis: Principles, Practices, Current Issues, New Research, and New Technologies. Washington, DC: Association for Professionals in Infection Control and Epidemiology; 2010: 223229.Google Scholar
Neves, MS, daSilva, MG, Ventura, GM, Cortes, PB, Duarte, RS, deSouza, HS. Effectiveness of current disinfection procedures against biofilm on contaminated GI endoscopes. Gastrointest Endosc 2015.Google Scholar
Ren-Pei, W H-JX, Ke, Q, Dong, W, Xing, N, Zhao-Shen, L,. Correlation between the growth of bacterial biofilm in flexible endoscopes and endoscope reprocessing methods. Am J Infect Control 2014;42: 12031206.Google Scholar
Agrawal, D, Muscarella, LF. Delayed reprocessing of endoscopes. Gastrointest Endosc 2011;73: 853854.Google Scholar
Rutala, WA WD. Outbreaks of carbapenem-resistant Enteriobacteriaceae infections associated with duodenoscopes: what can we do to prevent infections? Am J Infect Control;In press.Google Scholar
Otter, JA, Yezli, S, French, GL. The role played by contaminated surfaces in the transmission of nosocomial pathogens. Infect Control Hosp Epidemiol 2011;32: 687699.Google Scholar
Boyce, JM. Environmental contamination makes an important contribution to hospital infection. J Hosp Infect 2007;65 Suppl 2: 5054.Google Scholar
Weber, DJ, Anderson, DJ, Sexton, DJ, Rutala, WA. Role of the environment in the transmission of Clostridium difficile in health care facilities. Am J Infect Control 2013;41:S105S110.Google Scholar
Rutala, WA, Weber, DJ. Disinfectants used for environmental disinfection and new room decontamination technology. Am J Infect Control 2013;41:S36S41.Google Scholar
Stiefel, U, Cadnum, JL, Eckstein, BC, Guerrero, DM, Tima, MA, Donskey, CJ. Contamination of hands with methicillin-resistant Staphylococcus aureus after contact with environmental surfaces and after contact with the skin of colonized patients. Infect Control Hosp Epidemiol 2011;32: 185187.Google Scholar
Carling, P. Methods for assessing the adequacy of practice and improving room disinfection. Am J Infect Control 2013;41:S20S25.Google Scholar
Huang, SS, Datta, R, Platt, R. Risk of acquiring antibiotic-resistant bacteria from prior room occupants. Arch Intern Med 2006;166: 19451951.Google Scholar
Shaughnessy, MK, Micielli, RL, DePestel, DD, et al. Evaluation of hospital room assignment and acquisition of Clostridium difficile infection. Infect Control Hosp Epidemiol 2011;32: 201206.Google Scholar
Han, JH SN, Leas, BF, Pegues, DA, Kaczmarek, JL, Umscheid, CA. Cleaning hospital room surfaces to prevent health care-associated infections. Ann Intern Med 2015;163: 598607.CrossRefGoogle ScholarPubMed
Leas, BF SN, Han, JH, Pegues, DA, Kaczmarek, JL, Umscheid, CA. Environmental cleaning for the prevention of healthcare-associated infection. Technical brief No. 22 (prepared by the ECRI Institute – Penn Agency for Healthcare Research and Quality). www.effectivehealthcare.ahrq.gov/ehc/products/592/2103/healthcare-infections-report-150810.pdf2015.Google Scholar
Donskey, CJ. Does improving surface cleaning and disinfection reduce health care-associated infections? Am J Infect Control 2013;41:S12S19.Google Scholar
Rutala, WA, Weber, DJ. Selection of the ideal disinfectant. Infect Control Hosp Epidemiol 2014;35: 855865.Google Scholar
Cooper, RA, Griffith, CJ, Malik, RE, Obee, P, Looker, N. Monitoring the effectiveness of cleaning in four British hospitals. Am J Infect Control 2007;35: 338341.Google Scholar
Guh, A CP. Options for evaluating environmental cleaning. wwwcdc.gov/HAI/toolkits/Environ-Cleaning-Eval-Toolkit-10–6-2010.pdf2010.Google Scholar
Alfa, MJ, Fatima, I, Olson, N. Validation of adenosine triphosphate to audit manual cleaning of flexible endoscope channels. Am J Infect Control 2013;41: 245248.Google Scholar
Dancer, SJ. How do we assess hospital cleaning? A proposal for microbiological standards for surface hygiene in hospitals. J Hosp Infect 2004;56: 1015.Google Scholar
Lewis, T, Griffith, C, Gallo, M, Weinbren, M. A modified ATP benchmark for evaluating the cleaning of some hospital environmental surfaces. J Hosp Infect 2008;69: 156163.Google Scholar
Huslage, K, Rutala, WA, Gergen, MF, Sickbert-Bennett, EE, Weber, DJ. Microbial assessment of high-, medium-, and low-touch hospital room surfaces. Infect Control Hosp Epidemiol 2013;34: 211212.CrossRefGoogle ScholarPubMed
Carling, PC, Parry, MF, Von Beheren, SM, Healthcare Environmental Hygiene Group. Identifying opportunities to enhance environmental cleaning in 23 acute care hospitals. Infect Control Hosp Epidemiol 2008;29: 17.Google Scholar
Carling, PC, Von Beheren, S, Kim, P, Woods, C, Healthcare Environmental Hygiene Study Group. Intensive care unit environmental cleaning: an evaluation in sixteen hospitals using a novel assessment tool. J Hosp Infect 2008;68: 3944.Google Scholar
Havill, NL, Havill, HL, Mangione, E, Dumigan, DG, Boyce, JM. Cleanliness of portable medical equipment disinfected by nursing staff. Am J Infect Control 2011;39: 602604.CrossRefGoogle ScholarPubMed
Mitchell, BG, Dancer, SJ, Shaban, RZ, Graves, N. Moving forward with hospital cleaning. Am J Infect Control 2013;41: 11381139.Google Scholar
Carling, PC, Bartley, JM. Evaluating hygienic cleaning in health care settings: what you do not know can harm your patients. Am J Infect Control 2010;38:S41S50.CrossRefGoogle Scholar
Boyce, JM, Havill, NL, Dumigan, DG, Golebiewski, M, Balogun, O, Rizvani, R. Monitoring the effectiveness of hospital cleaning practices by use of an adenosine triphosphate bioluminescence assay. Infect Control Hosp Epidemiol 2009;30: 678684.Google Scholar
Hota, B BD, Lyle, EA, Weinstein, RA, Hayden, MK. Interventional evaluation of environmental contamination by vancomycin-resistant enterococci: failure of personnel, product or procedure? J Hosp Infect 2009;71: 123131.Google Scholar
Goodman, ER, Platt, R, Bass, R, Onderdonk, AB, Yokoe, DS, Huang, SS. Impact of an environmental cleaning intervention on the presence of methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci on surfaces in intensive care unit rooms. Infect Control Hosp Epidemiol 2008;29: 593599.CrossRefGoogle ScholarPubMed
Eckstein, BC, Adams, DA, Eckstein, EC, et al. Reduction of Clostridium difficile and vancomycin-resistant Enterococcus contamination of environmental surfaces after an intervention to improve cleaning methods. BMC Infect Dis 2007;7: 61.Google Scholar
Huslage, K, Rutala, WA, Sickbert-Bennett, E, Weber, DJ. A quantitative approach to defining “high-touch” surfaces in hospitals. Infect Control Hosp Epidemiol 2010;31: 850853.Google Scholar
Memarzadeh, F, Olmsted, RN, Bartley, JM. Applications of ultraviolet germicidal irradiation disinfection in health care facilities: effective adjunct, but not stand-alone technology. Am J Infect Control 2010;38:S13S24.Google Scholar
Nerandzic, MM, Thota, P, Sankar, CT, et al. Evaluation of a pulsed xenon ultraviolet disinfection system for reduction of healthcare-associated pathogens in hospital rooms. Infect Control Hosp Epidemiol 2015;36: 192197.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Room decontamination with UV radiation. Infect Control Hosp Epidemiol 2010;31: 10251029.CrossRefGoogle ScholarPubMed
Rutala, WA, Gergen, MF, Tande, BM, Weber, DJ. Room decontamination using an ultraviolet-C device with short ultraviolet exposure time. Infect Control Hosp Epidemiol 2014;35: 10701072.Google Scholar
Nerandzic, MM, Cadnum, JL, Pultz, MJ, Donskey, CJ. Evaluation of an automated ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens in hospital rooms. BMC Infect Dis 2010;10: 197.Google Scholar
Boyce, JM, Havill, NL, Moore, BA. Terminal decontamination of patient rooms using an automated mobile UV light unit. Infect Control Hosp Epidemiol 2011;32: 737742.Google Scholar
Boyce, JM, Havill, NL, Otter, JA, et al. Impact of hydrogen peroxide vapor room decontamination on Clostridium difficile environmental contamination and transmission in a healthcare setting. Infect Control Hosp Epidemiol 2008;29: 723729.Google Scholar
French, GL, Otter, JA, Shannon, KP, Adams, NM, Watling, D, Parks, MJ. Tackling contamination of the hospital environment by methicillin-resistant Staphylococcus aureus (MRSA): a comparison between conventional terminal cleaning and hydrogen peroxide vapour decontamination. J Hosp Infect 2004;57: 3137.Google Scholar
Bartels, MD, Kristoffersen, K, Slotsbjerg, T, Rohde, SM, Lundgren, B, Westh, H. Environmental methicillin-resistant Staphylococcus aureus (MRSA) disinfection using dry-mist-generated hydrogen peroxide. J Hosp Infect 2008;70: 3541.Google Scholar
Hall, L, Otter, JA, Chewins, J, Wengenack, NL. Use of hydrogen peroxide vapor for deactivation of Mycobacterium tuberculosis in a biological safety cabinet and a room. J Clin Microbiol 2007;45: 810815.Google Scholar
Hardy, KJ, Gossain, S, Henderson, N, et al. Rapid recontamination with MRSA of the environment of an intensive care unit after decontamination with hydrogen peroxide vapour. J Hosp Infect 2007;66: 360368.Google Scholar
Johnston, MD, Lawson, S, Otter, JA. Evaluation of hydrogen peroxide vapour as a method for the decontamination of surfaces contaminated with Clostridium botulinum spores. J Microbiol Methods 2005;60: 403411.CrossRefGoogle ScholarPubMed
Heckert, RA, Best, M, Jordan, LT, Dulac, GC, Eddington, DL, Sterritt, WG. Efficacy of vaporized hydrogen peroxide against exotic animal viruses. Appl Environ Microbiol 1997;63: 39163918.Google Scholar
Klapes, NA, Vesley, D. Vapor-phase hydrogen peroxide as a surface decontaminant and sterilant. Appl Environ Microbiol 1990;56: 503506.Google Scholar
Bates, CJ, Pearse, R. Use of hydrogen peroxide vapour for environmental control during a Serratia outbreak in a neonatal intensive care unit. J Hosp Infect 2005;61: 364366.Google Scholar
Shapey, S, Machin, K, Levi, K, Boswell, TC. Activity of a dry mist hydrogen peroxide system against environmental Clostridium difficile contamination in elderly care wards. J Hosp Infect 2008;70: 136141.Google Scholar
Falagas, ME, Thomaidis, PC, Kotsantis, IK, Sgouros, K, Samonis, G, Karageorgopoulos, DE. Airborne hydrogen peroxide for disinfection of the hospital environment and infection control: a systematic review. J Hosp Infect 2011;78: 171177.Google Scholar
Weber, DJ RW, Anderson, DJ, Chen, LF, Sickbert-Bennett, EE, Boyce, JM. Effectiveness of UV devices and hydrogen peroxide systems for terminal room decontamination: focus on clinical trials. Am J Infect Control. In press.Google Scholar
Passaretti, CL, Otter, JA, Reich, NG, et al. An evaluation of environmental decontamination with hydrogen peroxide vapor for reducing the risk of patient acquisition of multidrug-resistant organisms. Clin Infect Dis 2013;56: 2735.Google Scholar
Levin, J RL, Parrish, C, English, D, Ahn, S. The effect of portable pulsed xenon ultraviolet light after terminal cleaning on hospital-associated Clostridium difficile infection in a community hospital. Am J Infect Control 2013;42: 586590.Google Scholar
Haas, JP MJ, Dusza, S, Montecalvo, MA. Implementation and impact of ultraviolet environmental disinfection in an acute care setting. Am J Infect Control 2014;42: 586590.Google Scholar
Meyers, J RE, Conway, MJ, Meyers, C, Robison, R,. Susceptibility of high-risk human papillomavirus type 16 to clinical disinfectants. J Antimicrob Chemother 2014;Epub February 2014.Google Scholar
Ryndock, E RR, Meyers, C. Susceptibility of HPV 16 and 18 to high-level disinfectants indicated for semi-critical ultrasound probes. J Med Virol 2015;Epub ahead of print.Google Scholar
Bringhurst, J. Disinfection and sterilization in physician practices and specialty clinics. Am J Infect Control; In press.Google Scholar
Rutala, WA GM, Bringhurst, J, Weber, DJ. Effective high-level disinfection pf cystoscopes: is perfusion of channels required? Infect Control Hosp Epidemiol; In press.Google Scholar
Wendelboe, AM BJ, Blossom, DB, Frank, P, Srinivasan, A, Sewell, CM. Outbreak of cystoscopy related infections with Pseudomonas aeurginosa: New Mexico, 2007. J Urology 2008;180: 588592.CrossRefGoogle Scholar
Dubberke, ER, Carling, P, Carrico, R, et al. Strategies to prevent Clostridium difficile infections in acute care hospitals: 2014 update. Infect Control Hosp Epidemiol 2014;35 Suppl 2:S48S65.Google Scholar
Magill, SS EJ, Bamberg, W, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med 2014;370: 11981208.Google Scholar
Khanafer, N, Voirin, N, Barbut, F, Kuijper, E, Vanhems, P. Hospital management of Clostridium difficile infection: a review of the literature. J Hosp Infect 2015;90: 91101.Google Scholar
Bartlett, JG. Narrative review: the new epidemic of Clostridium difficile-associated enteric disease. Ann Intern Med 2006;145: 758764.Google Scholar
Guerrero, DM, Nerandzic, MM, Jury, LA, Jinno, S, Chang, S, Donskey, CJ. Acquisition of spores on gloved hands after contact with the skin of patients with Clostridium difficile infection and with environmental surfaces in their rooms. Am J Infect Control 2012;40: 556558.Google Scholar
Kundrapu, S, Sunkesula, V, Jury, LA, Sitzlar, BM, Donskey, CJ. Daily disinfection of high-touch surfaces in isolation rooms to reduce contamination of healthcare workers’ hands. Infect Control Hosp Epidemiol 2012;33: 10391042.Google Scholar
Barbut, F. How to eradicate Clostridium difficile from the environment. J Hosp Infect 2015;89: 287295.Google Scholar
Kim, KH, Fekety, R, Batts, DH, et al. Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis 1981;143: 4250.Google Scholar
Jump, RL, Pultz, MJ, Donskey, CJ. Vegetative Clostridium difficile survives in room air on moist surfaces and in gastric contents with reduced acidity: a potential mechanism to explain the association between proton pump inhibitors and C. difficile-associated diarrhea? Antimicrob Agents Chemother 2007;51: 28832887.Google Scholar
Association for Professionals in Infection Control and Epidemiology. Guide to the Elimination of Clostridium difficile in Healthcare Settings. Washington DC: APIC; 2008.Google Scholar
McFarland, LV, Mulligan, ME, Kwok, RY, Stamm, WE. Nosocomial acquisition of Clostridium difficile infection. N Engl J Med 1989;320: 204210.Google Scholar
Jou, J, Ebrahim, J, Shofer, FS, et al. Environmental transmission of Clostridium difficile: association between hospital room size and C. difficile infection. Infect Control Hosp Epidemiol 2015;36: 564568.CrossRefGoogle ScholarPubMed
Wilcox, MH, Fawley, WN, Wigglesworth, N, Parnell, P, Verity, P, Freeman, J. Comparison of the effect of detergent versus hypochlorite cleaning on environmental contamination and incidence of Clostridium difficile infection. J Hosp Infect 2003;54: 109114.Google Scholar
Samore, MH, Venkataraman, L, DeGirolami, PC, Arbeit, RD, Karchmer, AW. Clinical and molecular epidemiology of sporadic and clustered cases of nosocomial Clostridium difficile diarrhea. Am J Med 1996;100: 3240.Google Scholar
Sitzlar, B, Deshpande, A, Fertelli, D, Kundrapu, S, Sethi, AK, Donskey, CJ. An environmental disinfection odyssey: evaluation of sequential interventions to improve disinfection of Clostridium difficile isolation rooms. Infect Control Hosp Epidemiol 2013;34: 459465.Google Scholar
Gerding, DN, Muto, CA, Owens, RC Jr. Measures to control and prevent Clostridium difficile infection. Clin Infect Dis 2008;46 Suppl 1:S43S49.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Efficacy of different cleaning and disinfection methods against Clostridium difficile spores: importance of physical removal versus sporicidal inactivation. Infect Control Hosp Epidemiol 2012;33: 12551258.Google Scholar
Kaatz, GW, Gitlin, SD, Schaberg, DR, et al. Acquisition of Clostridium difficile from the hospital environment. Am J Epidemiol 1988;127: 12891294.Google Scholar
Cohen, SH, Tang, YJ, Rahmani, D, Silva, J Jr. Persistence of an endemic (toxigenic) isolate of Clostridium difficile in the environment of a general medicine ward. Clin Infect Dis 2000;30: 952954.Google Scholar
Fekety, R, Kim, KH, Brown, D, Batts, DH, Cudmore, M, Silva, J Jr. Epidemiology of antibiotic-associated colitis; isolation of Clostridium difficile from the hospital environment. Am J Med 1981;70: 906908.Google Scholar
Mayfield, JL, Leet, T, Miller, J, Mundy, LM. Environmental control to reduce transmission of Clostridium difficile. Clin Infect Dis 2000;31: 9951000.Google Scholar
Cohen, SH, Tang, YJ, Muenzer, J, Gumerlock, PH, Silva, J Jr. Isolation of various genotypes of Clostridium difficile from patients and the environment in an oncology ward. Clin Infect Dis 1997;24: 889893.Google Scholar
Dubberke, ER, Reske, KA, Noble-Wang, J, et al. Prevalence of Clostridium difficile environmental contamination and strain variability in multiple health care facilities. Am J Infect Control 2007;35: 315318.Google Scholar
Verity, P, Wilcox, MH, Fawley, W, Parnell, P. Prospective evaluation of environmental contamination by Clostridium difficile in isolation side rooms. J Hosp Infect 2001;49: 204209.Google Scholar
Mulligan, ME, George, WL, Rolfe, RD, Finegold, SM. Epidemiological aspects of Clostridium difficile-induced diarrhea and colitis. Am J Clin Nutr 1980;33: 25332538.Google Scholar
Perez, J, Springthorpe, VS, Sattar, SA. Activity of selected oxidizing microbicides against the spores of Clostridium difficile: relevance to environmental control. Am J Infect Control 2005;33: 320325.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Inactivation of Clostridium difficile spores by disinfectants. Infect Control Hosp Epidemiol 1993;14: 3639.Google Scholar
Centers for Disease C, Prevention. Surveillance for Creutzfeldt-Jakob disease–United States. MMWR Morb Mortal Wkly Rep 1996;45: 665668.Google Scholar
Johnson, RT, Gibbs, CJ Jr. Creutzfeldt-Jakob disease and related transmissible spongiform encephalopathies. N Engl J Med 1998;339:19942004.Google Scholar
Collins, SJ, Lawson, VA, Masters, CL. Transmissible spongiform encephalopathies. Lancet 2004;363: 5161.Google Scholar
Brown, P, Brandel, JP, Preece, M, Sato, T. Iatrogenic Creutzfeldt-Jakob disease: the waning of an era. Neurology 2006;67: 389393.Google Scholar
WHO infection control guidelines for transmissible spongiform encephalopathies. 2003. at wwwwho.int/csr/resources/publications/bse/whocdscsraph2003.pdf.Google Scholar
Brown, P, Preece, M, Brandel, JP, et al. Iatrogenic Creutzfeldt-Jakob disease at the millennium. Neurology 2000;55: 10751081.Google Scholar
Brown, P. Environmental causes of human spongiform encephalopathy. In: Baker HR, R. M., eds., Methods in Molecular Medicine: Prion Diseases. Totowa, NJ: Humana Press Inc.; 1996: 139154.Google Scholar
Brown, P, Gibbs, CJ Jr., Rodgers-Johnson, P, et al. Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol 1994;35: 513529.Google Scholar
Rabano AdP-C, J, Pedro-Cuesta, J, Molbak, K. et al. Tissue classification for the epidemiological assessment of surgical transmission of sporadic Creutzfeldt-Jakob disease: a proposal on hypothetical risk levels. BMC Public Health 2005;5.Google Scholar
Rutala, WA, Weber, DJ, Society for Healthcare Epidemiology of A. Guideline for disinfection and sterilization of prion-contaminated medical instruments. Infect Control Hosp Epidemiol 2010;31: 107117.Google Scholar
Belay, ED, Blase, J, Sehulster, LM, Maddox, RA, Schonberger, LB. Management of neurosurgical instruments and patients exposed to Creutzfeldt-Jakob disease. Infect Control Hosp Epidemiol 2013;34: 12721280.Google Scholar
Rutala, WA, Weber, DJ. Creutzfeldt-Jakob disease: recommendations for disinfection and sterilization. Clin Infect Dis 2001;32: 13481356.Google Scholar
Favero, MS. Current issues in hospital hygiene and sterilization technology. J Infect Control (Asia Pacific Edition) 1998;1: 810.Google Scholar
Favero, MS BW. Chemical disinfection of medical and surgical materials. In: SS B, ed. Disinfection, Sterilization, and Preservation. Philadelphia, PA: Lea & Febiger; 2001: 881917.Google Scholar
Jacobs, P. Cleaning: principles, methods and benefits. In: WA R, ed. Disinfection, Sterilization, and Antisepsis in Healthcare. Champlain, NY: Polyscience Publications; 1998: 165181.Google Scholar
Merritt, K HV, Brown, SA. Safety and cleaning of medical materials and devices. Journal of Biomedical Materials Research 2000;53: 131136.Google Scholar
Alfa, MJ, Jackson, M. A new hydrogen peroxide–based medical-device detergent with germicidal properties: comparison with enzymatic cleaners. Am J Infect Control 2001;29: 168177.Google Scholar
Lipscomb, IP, Pinchin, H, Collin, R, Keevil, CW. Effect of drying time, ambient temperature and pre-soaks on prion-infected tissue contamination levels on surgical stainless steel: concerns over prolonged transportation of instruments from theatre to central sterile service departments. J Hosp Infect 2007;65: 7277.Google Scholar
Fichet, G, Comoy, E, Duval, C, et al. Novel methods for disinfection of prion-contaminated medical devices. Lancet 2004;364: 521526.Google Scholar
Baier, M, Schwarz, A, Mielke, M. Activity of an alkaline “cleaner” in the inactivation of the scrapie agent. J Hosp Infect 2004;57: 8084.Google Scholar
Yoshioka, M, Murayama, Y, Miwa, T, et al. Assessment of prion inactivation by combined use of Bacillus-derived protease and SDS. Biosci Biotechnol Biochem 2007;71: 25652658.Google Scholar
Yan ZXS, L; Heeg, P, Roth, K, Mauz, P-S. Low-temperature inactivation of prion-protein on surgical steel surfaces with hydrogen peroxide gas plasma sterilization. Zentr Steril 2008;16: 2634.Google Scholar
Jackson, GS, McKintosh, E, Flechsig, E, et al. An enzyme-detergent method for effective prion decontamination of surgical steel. J Gen Virol 2005;86: 869878.Google Scholar
Lawson, VA, Stewart, JD, Masters, CL. Enzymatic detergent treatment protocol that reduces protease-resistant prion protein load and infectivity from surgical-steel monofilaments contaminated with a human-derived prion strain. J Gen Virol 2007;88: 29052914.Google Scholar
McDonnell, G. Prion disease transmission: can we apply standard precautions to prevent or reduce risks? Healthcare Challenges 2008;18: 298304.Google Scholar
United Kingdom Department of Health. New Technologies Working Group Report on Prion Inactivating Agents. London: 2008.Google Scholar
Fichet, GH, Harrison, J, McDonnell, G. Reduction of risk of prion transmission on surgical devices with effective cleaning processes. Zentr Steril 2007;15: 418437.Google Scholar
Taylor, DM. Inactivation of transmissible degenerative encephalopathy agents: a review. Veterinary J 2000;159: 1017.Google Scholar
Kampf, G, Bloss, R, Martiny, H. Surface fixation of dried blood by glutaraldehyde and peracetic acid. J Hosp Infect 2004;57: 139143.Google Scholar
Taylor, DM, McConnell, I. Autoclaving does not decontaminate formol-fixed scrapie tissues. Lancet 1988;1: 14631464.Google Scholar
Brown, P, Liberski, PP, Wolff, A, Gajdusek, DC. Resistance of scrapie infectivity to steam autoclaving after formaldehyde fixation and limited survival after ashing at 360 degrees C: practical and theoretical implications. J Infect Dis 1990;161: 467472.Google Scholar
Fernie, K, Steele, PJ, Taylor, DM, Somerville, RA. Comparative studies on the thermostability of five strains of transmissible-spongiform-encephalopathy agent. Biotechnol Appl Biochem 2007;47: 175183.Google Scholar
Yan, ZX SL, Heeg, P, Pfaff, E, Roth, K. Infectivity of prion protein bound to stainless steel wires: a model for testing decontamination procedures for transmissible spongiform encephalopathies. Infect Control Hosp Epidemiol 2004;25: 280283.Google Scholar
Taylor, DM, Fraser, H, McConnell, I, et al. Decontamination studies with the agents of bovine spongiform encephalopathy and scrapie. Arch Virol 1994;139: 313326.Google Scholar
Vadrot, C, Darbord, JC. Quantitative evaluation of prion inactivation comparing steam sterilization and chemical sterilants: proposed method for test standardization. J Hosp Infect 2006;64: 143148.Google Scholar
Taylor, DM. Inactivation of prions by physical and chemical means. J Hosp Infect 1999;43 Suppl:S69S76.Google Scholar
Peretz, D, Supattapone, S, Giles, K, et al. Inactivation of prions by acidic sodium dodecyl sulfate. J Virol 2006;80: 322331.Google Scholar
Kimberlin, RH, Walker, CA, Millson, GC, et al. Disinfection studies with two strains of mouse-passaged scrapie agent: guidelines for Creutzfeldt-Jakob and related agents. J Neurol Sci 1983;59: 355369.Google Scholar
Taguchi, F, Tamai, Y, Uchida, K, et al. Proposal for a procedure for complete inactivation of the Creutzfeldt-Jakob disease agent. Arch Virol 1991;119: 297301.Google Scholar
Ernst, DR, Race, RE. Comparative analysis of scrapie agent inactivation methods. J Virol Methods 1993;41: 193201.Google Scholar
Brown, P, Rohwer, RG, Gajdusek, DC. Newer data on the inactivation of scrapie virus or Creutzfeldt-Jakob disease virus in brain tissue. J Infect Dis 1986;153: 11451148.Google Scholar
Taylor, DM, Fernie, K, McConnell, I. Inactivation of the 22 A strain of scrapie agent by autoclaving in sodium hydroxide. Vet Microbiol 1997;58: 8791.Google Scholar
Brown, SA, Merritt, K. Use of containment pans and lids for autoclaving caustic solutions. Am J Infect Control 2003;31: 257260.CrossRefGoogle ScholarPubMed
Association of periOperative Registered Nurses. Recommended practices for cleaning and care of surgical instruments and powered equipment. In: Nurses, Aop-OR, ed. Perioperative Standards and Recommended Practices 2014: 555563. Available at www.aornstandards.org/.Google Scholar
Association for the Advancement of Medical Instrumentation ANSI. Comprehensive Guide to Steam Sterilization and Sterility Assurance in Health Care Facilities. Arlington, VA: Association for the Advancement of Medical Instrumentation, 2010.Google Scholar
Race, RE, Raymond, GJ. Inactivation of transmissible spongiform encephalopathy (prion) agents by environ LpH. J Virol 2004;78: 21642165.Google Scholar
Brown, P, Rohwer, RG, Green, EM, Gajdusek, DC. Effect of chemicals, heat, and histopathologic processing on high-infectivity hamster-adapted scrapie virus. J Infect Dis 1982;145: 683687.Google Scholar
Brown, P, Gibbs, CJ Jr., Amyx, HL, et al. Chemical disinfection of Creutzfeldt-Jakob disease virus. N Engl J Med 1982;306: 12791282.Google Scholar
Lemmer, K, Mielke, M, Pauli, G, Beekes, M. Decontamination of surgical instruments from prion proteins: in vitro studies on the detachment, destabilization and degradation of PrPSc bound to steel surfaces. J Gen Virol 2004;85: 38053816.Google Scholar
Clinical and Laboratory Standards Institute. Protection of laboratory workers from occupationally acquired infections: Approved guideline. 2005.Google Scholar
Fichet, G CE, Dehen, C, Challier, L, Antloga, K, Deslys, JP, McDonnell, G,. Investigations of a prion infectivity assay to evaluate methods of decontamination. J Microbiol Methods 2007;70: 511518.Google Scholar
Cook BWM, CT, Nikiforuk, AM, Poliquin, PG, Court, DA, Strong, JE, Theriault, SS. Evaluating environmental persistence and disinfection of the Ebola Virus Makona Variant. Viruses 2015;7: 19751986.Google Scholar
Klein, M DA. The inactivation of viruses by germicides. Chem Specialists Manuf Assoc Proc 1963;49: 116118.Google Scholar
Rutala, WA, Gergen, MF, Weber, DJ. Sporicidal activity of a new low-temperature sterilization technology: the Sterrad 50 sterilizer. Infect Control Hosp Epidemiol 1999;20: 514516.Google Scholar
Sattar, SA. Hierarchy of susceptibility of viruses to environmental surface disinfectants: a predictor of activity against new and emerging viral pathogens. J AOAC Int 2007;90: 16551658.Google Scholar
Rutala, WA, Weber, DJ. Registration of disinfectants based on relative microbicidal activity. Infect Control Hosp Epidemiol 2004;25: 333341.Google Scholar
Hulkower, RL, Casanova, LM, Rutala, WA, Weber, DJ, Sobsey, MD. Inactivation of surrogate coronaviruses on hard surfaces by health care germicides. Am J Infect Control 2011;39: 401407.Google Scholar
Sattar, SA, Springthorpe, VS, Karim, Y, Loro, P. Chemical disinfection of non-porous inanimate surfaces experimentally contaminated with four human pathogenic viruses. Epidemiol Infect 1989;102: 493505.Google Scholar
Rutala, WA, Stiegel, MM, Sarubbi, FA, Weber, DJ. Susceptibility of antibiotic-susceptible and antibiotic-resistant hospital bacteria to disinfectants. Infect Control Hosp Epidemiol 1997;18: 417421.Google Scholar
Anderson, RL, Carr, JH, Bond, WW, Favero, MS. Susceptibility of vancomycin-resistant enterococci to environmental disinfectants. Infect Control Hosp Epidemiol 1997;18: 195199.Google Scholar
Rutala, WA, Barbee, SL, Aguiar, NC, Sobsey, MD, Weber, DJ. Antimicrobial activity of home disinfectants and natural products against potential human pathogens. Infect Control Hosp Epidemiol 2000;21: 3338.Google Scholar
Kohn, WG, Collins, AS, Cleveland, JL, et al. Guidelines for infection control in dental healthcare settings – 2003. MMWR Recomm Rep 2003;52: 161.Google Scholar
Rutala, WA, Weber, DJ Disinfection and sterilization of prion-contaminated medical instruments, Reply to Belay. Infect Control Hosp Epidemiol 2010;31: 13061307.Google Scholar
Weber, DJ, Rutala, WA, Sickbert-Bennett, EE. Outbreaks associated with contaminated antiseptics and disinfectants. Antimicrob Agents Chemother 2007;51: 42174224.Google Scholar
Rutala, WA, Cole, EC, Thomann, CA, Weber, DJ. Stability and bactericidal activity of chlorine solutions. Infect Control Hosp Epidemiol 1998;19: 323327.Google Scholar

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