Skip to main content Accessibility help
×
Hostname: page-component-848d4c4894-tn8tq Total loading time: 0 Render date: 2024-06-27T04:40:00.677Z Has data issue: false hasContentIssue false

Chapter 28 - Management of dyspnea in older adults with cancer

from Part 4 - Symptom management and supportive care of older adults

Published online by Cambridge University Press:  05 August 2011

Arti Hurria
Affiliation:
City of Hope Cancer Center, California
Harvey Jay Cohen
Affiliation:
Duke University Medical Center, Durham
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Vainio, A, Auvinen, A. Prevalence of symptoms among patients with advanced cancer: an international collaborative study. Symptom Prevalence Group. J Pain Symptom Manage. 1996;12(1):3–10.CrossRefGoogle Scholar
Krech, RL, Walsh, D. Symptoms of pancreatic cancer. J Pain Symptom Manage. 1991;6(6):360–367.CrossRefGoogle ScholarPubMed
Brescia, FJ, Adler, D, Gray, G. Hospitalized advanced cancer patients: a profile. J Pain Symptom Manage. 1990;5(4):221–227.CrossRefGoogle ScholarPubMed
Coyle, N, Adelhardt, J, Foley, KM. Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life. J Pain Symptom Manage. 1990;5(2):83–93.CrossRefGoogle ScholarPubMed
Higginson, I, McCarthy, M. Measuring symptoms in terminal cancer: are pain and dyspnoea controlled? J R Soc Med. 1989;82(5):264–267.CrossRefGoogle ScholarPubMed
Reuben, DB, Mor, V, Hiris, J. Clinical symptoms and length of survival in patients with terminal cancer. Arch Intern Med. 1988;148(7):1586–1591.CrossRefGoogle ScholarPubMed
Reuben, DB, Mor, V. Dyspnea in terminally ill cancer patients. Chest. 1986;89(2):234–236.CrossRefGoogle ScholarPubMed
Dudgeon, DJ, Kristjanson, L, Sloan, JA. Dyspnea in cancer patients: prevalence and associated factors. J Pain Symptom Manage. 2001;21(2):95–102.CrossRefGoogle ScholarPubMed
Currow, DC, Plummer, JL, Crockett, A. A community population survey of prevalence and severity of dyspnea in adults. J Pain Symptom Manage. 2009:38(4):533–545.CrossRefGoogle ScholarPubMed
Salminen, E, Clemens, KE, Syrjanen, K. Needs of developing the skills of palliative care at the oncology ward: an audit of symptoms among 203 consecutive cancer patients in Finland. Supportive Care Cancer. 2008;16(1):3–8.CrossRefGoogle ScholarPubMed
Tsai, J-S, Wu, C-H, Chiu, T-Y. Symptom patterns of advanced cancer patients in a palliative care unit. Palliative Med. 2006;20(6):617–622.CrossRefGoogle Scholar
Chiu, T-Y, Hu, W-Y, Lue, B-H. Dyspnea and its correlates in Taiwanese patients with terminal cancer. J Pain Symptom Manage. 2004;28(2):123–132.CrossRefGoogle ScholarPubMed
Mercadante, S, Casuccio, A, Fulfaro, F. The course of symptom frequency and intensity in advanced cancer patients followed at home. J Pain Symptom Manage. 2000;20(2):104–112.CrossRefGoogle ScholarPubMed
Bruera, E, Schoeller, T, MacEachern, T. Symptomatic benefit of supplemental oxygen in hypoxemic patients with terminal cancer: the use of the N of 1 randomized controlled trial. J Pain Symptom Manage. 1992;7(6):365–368.CrossRefGoogle Scholar
Dudgeon, DJ. Managing dyspnea and cough. Hematol Oncol Clin N Am. 2002;16(3):557–577.CrossRefGoogle ScholarPubMed
Dudgeon, DJ, Lertzman, M, Dudgeon, DJ. Dyspnea in the advanced cancer patient. J Pain Symptom Manage. 1998;16(4):212–219.CrossRefGoogle ScholarPubMed
Tanaka, K, Akechi, T, Okuyama, T. Development and validation of the Cancer Dyspnoea Scale: a multidimensional, brief, self-rating scale. Br J Cancer. 2000;82(4): 800–805.CrossRefGoogle ScholarPubMed
Edmonds, P, Higginson, I, Altmann, D. Is the presence of dyspnea a risk factor for morbidity in cancer patients? J Pain Symptom Manage. 2000;19(1):15–22.CrossRefGoogle ScholarPubMed
,Dyspnea: mechanisms, assessment, and management: a consensus statement. American Thoracic Society. Am J Respir Crit Care Med. 1999;159(1):321–340.Google Scholar
Luce, JM, Luce, JA, Luce, JM. Perspectives on care at the close of life: management of dyspnea in patients with far-advanced lung disease: “once I lose it, it's kind of hard to catch it.…”J Am Med Assoc. 2001;285(10):1331–1337.CrossRefGoogle Scholar
Cristiano, LM, Schwartzstein, RM, Cristiano, LM. Effect of chest wall vibration on dyspnea during hypercapnia and exercise in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1997;155(5):1552–1559.CrossRefGoogle ScholarPubMed
O';Donnell, , Webb, KA, O';Donnell, . Exertional breathlessness in patients with chronic airflow limitation: the role of lung hyperinflation. Am Rev Respir Dis. 1993;148(5):1351–1357.CrossRefGoogle Scholar
Nishino, T, Ide, T, Sudo, T. Inhaled furosemide greatly alleviates the sensation of experimentally induced dyspnea. Am J Respir Crit Care Med. 2000;161(6):1963–1967.CrossRefGoogle ScholarPubMed
Ferrell, BA. Pain evaluation and management in the nursing home. Ann Intern Med. 1995;123(9):681–687.CrossRefGoogle ScholarPubMed
Rao, AV, Hsieh, F, Feussner, JR. Geriatric evaluation and management units in the care of the frail elderly cancer patient. J Gerontol. 2005;60(6):798–803.CrossRefGoogle ScholarPubMed
Papiris, SA, Daniil, ZD, Malagari, K. The Medical Research Council dyspnea scale in the estimation of disease severity in idiopathic pulmonary fibrosis. Respir Med. 2005;99(6):755–761.CrossRefGoogle ScholarPubMed
Uronis, HE, Blackwell, S, Bosworth, H. An examination of the psychometric properties of an English version of the Cancer Dyspnea Scale (CDS) for evaluating dyspnea in patients with advanced lung cancer. Support Care Cancer. 2007;15:728.Google Scholar
Hardy, JR, Turner, R, Saunders, M. Prediction of survival in a hospital-based continuing care unit. Eur J Cancer. 1994;30A(3):284–288.CrossRefGoogle Scholar
Chang, VT, Thaler, HT, Polyak, TA. Quality of life and survival: the role of multidimensional symptom assessment. Cancer. 1998;83(1):173–179.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Abernethy, AP, Currow, DC, Frith, P. Randomised, double blind, placebo controlled crossover trial of sustained release morphine for the management of refractory dyspnoea [see comment]. Br Med J. 2003;327(7414):523–528.CrossRefGoogle Scholar
Currow, DC, Abernethy, AP, Frith, P. Morphine for management of refractory dyspnea. Br Med J. 2003;327:1288–1289.CrossRefGoogle Scholar
Pauwels, RA, Buist, AS, Calverley, PM. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med. 2001;163(5):1256–1276.CrossRefGoogle ScholarPubMed
Leach, RM.Palliative medicine and non-malignant, end-stage respiratory disease. In: Doyle, D, Hanks, G, Cherny, N, eds. Oxford Textbook of Palliative Medicine. 3rd ed. New York: Oxford University Press; 2005:895–916.Google Scholar
Eckenhoff, JE, Oech, SR. The effects of narcotics and antagonists upon respiration and circulation in man: a review. Clin Pharmacol Ther. 1960;1:483–524.Google Scholar
Santiago, TV, Pugliese, AC, Edelman, NH. Control of breathing during methadone addiction. Am J Med. 1977;62(3):347–354.CrossRefGoogle ScholarPubMed
Weil, JV, McCullough, RE, Kline, JS. Diminished ventilatory response to hypoxia and hypercapnia after morphine in normal man. N Engl J Med. 1975;292(21):1103–1106.CrossRefGoogle ScholarPubMed
Kryger, MH, Yacoub, O, Dosman, J. Effect of meperidine on occlusion pressure responses to hypercapnia and hypoxia with and without external inspiratory resistance. Am Rev Respir Dis. 1976;114(2):333–340.Google ScholarPubMed
Santiago, TV, Johnson, J, Riley, DJ. Effects of morphine on ventilatory response to exercise. J Appl Physiol. 1979;47(1):112–118.CrossRefGoogle ScholarPubMed
Jennings, AL, Davies, AN, Higgins, JP. A systematic review of the use of opioids in the management of dyspnoea. Thorax. 2002;57(11):939–944.CrossRefGoogle ScholarPubMed
Bruera, E, MacEachern, T, Ripamonti, C. Subcutaneous morphine for dyspnea in cancer patients. Ann Intern Med. 1993;119(9):906–907.CrossRefGoogle ScholarPubMed
Mazzocato, C, Buclin, T, Rapin, CH. The effects of morphine on dyspnea and ventilatory function in elderly patients with advanced cancer: a randomized double-blind controlled trial. Ann Oncol. 1999;10(12):1511–1514.CrossRefGoogle ScholarPubMed
Buck, C, Laier-Groeneveld, G, Criee, CP. The effect of dihydrocodeine and terbutaline on breathlessness and inspiratory muscle function in normal subjects and patients with COPD [abstract]. Eur Respir J. 1996;9:344S.Google Scholar
Chua, TP, Harrington, D, Ponikowski, P. Effects of dihydrocodeine on chemosensitivity and exercise tolerance in patients with chronic heart failure. J Am Coll Cardiol. 1997;29(1):147–152.CrossRefGoogle ScholarPubMed
Johnson, MA, Woodcock, AA, Geddes, DM. Dihydrocodeine for breathlessness in “pink puffers.” Br Med J Clin Res Ed. 1983;286(6366):675–677.CrossRefGoogle ScholarPubMed
Woodcock, AA, Gross, ER, Gellert, A. Effects of dihydrocodeine, alcohol, and caffeine on breathlessness and exercise tolerance in patients with chronic obstructive lung disease and normal blood gases. N Engl J Med. 1981;305(27):1611–1616.CrossRefGoogle ScholarPubMed
Viola, R, Kiteley, C, Lloyd, NS. The management of dyspnea in cancer patients: a systematic review. Support Care Cancer. 2008;16(4):329–337.CrossRefGoogle ScholarPubMed
Booth, S, Anderson, H, Swannick, M. The use of oxygen in the palliation of breathlessness: a report of the expert working group of the Scientific Committee of the Association of Palliative Medicine. Respir Med. 2004;98(1): 66–77.CrossRefGoogle Scholar
Uronis, HE, Currow, DC, McCrory, DC. Oxygen for relief of dyspnoea in mildly- or non-hypoxaemic patients with cancer: a systematic review and meta-analysis. Br J Cancer. 2008;98(2):294–299.CrossRefGoogle ScholarPubMed
Guyatt, GH, McKim, DA, Austin, P. Appropriateness of domiciliary oxygen delivery. Chest. 2000;118(5):1303–1308.CrossRefGoogle ScholarPubMed
Abernethy, AP, Currow, DC, Frith, PA. Prescribing palliative oxygen: a clinician survey of expected benefit and patterns of use. Palliative Med. 2005;19:165–172.CrossRefGoogle ScholarPubMed
Stringer, E, McParland, C, Hernandez, P. Physician practices for prescribing supplemental oxygen in the palliative care setting. J Palliative Care. 2004;20(4):303–307.Google ScholarPubMed
Abernethy, AP, McDonald, C, Frith, P. Palliative oxygen versus medical air for relief of dyspnea: results of an international, multi-site, randomized controlled trial. Paper presented at: Annual Assembly of the American Academy of Hospice and Palliative Medicine and Hospice and Palliative Nurses Association; March 27, 2009; Austin, TX.
Currow, DC, Fazekas, B, Abernethy, AP. Oxygen use – patients define symptomatic benefit discerningly. J Pain Symptom Manage. 2007;34(2):113–114.CrossRefGoogle ScholarPubMed
Kim, HF, Kunik, ME, Molinari, VA. Functional impairment in COPD patients: the impact of anxiety and depression. Psychosomatics. 2000;41(6):465–471.CrossRefGoogle ScholarPubMed
Mitchell-Heggs, P, Murphy, K, Minty, K. Diazepam in the treatment of dyspnoea in the “Pink Puffer” syndrome. Q J Med. 1980;49(193):9–20.Google ScholarPubMed
Sen, D, Jones, G, Leggat, PO. The response of the breathless patient treated with diazepam. Br J Clin Pract. 1983;37(6):232–233.Google ScholarPubMed
Woodcock, AA, Gross, ER, Geddes, DM. Drug treatment of breathlessness: contrasting effects of diazepam and promethazine in pink puffers. Br Med J Clin Res Ed. 1981;283(6287): 343–346.CrossRefGoogle ScholarPubMed
Navigante, AH, Cerchietti, LC, Castro, MA. Midazolam as adjunct therapy to morphine in the alleviation of severe dyspnea perception in patients with advanced cancer. J Pain Symptom Manage. 2006;31(1):38–47.CrossRefGoogle ScholarPubMed
Man, GC, Hsu, K, Sproule, BJ. Effect of alprazolam on exercise and dyspnea in patients with chronic obstructive pulmonary disease. Chest. 1986;90(6):832–836.CrossRefGoogle ScholarPubMed
Eimer, M, Cable, T, Gal, P. Effects of clorazepate on breathlessness and exercise tolerance in patients with chronic airflow obstruction. J Fam Pract. 1985;21(5):359–362.Google ScholarPubMed
Garner, SJ, Eldridge, FL, Wagner, PG. Buspirone, an anxiolytic drug that stimulates respiration. Am Rev Respir Dis. 1989;139(4):946–950.CrossRefGoogle ScholarPubMed
Mendelson, WB, Martin, JV, Rapoport, DM. Effects of buspirone on sleep and respiration. Am Rev Respir Dis. 1990;141(6):1527–1530.CrossRefGoogle ScholarPubMed
Argyropoulou, P, Patakas, D, Koukou, A. Buspirone effect on breathlessness and exercise performance in patients with chronic obstructive pulmonary disease. Respiration. 1993;60(4):216–220.CrossRefGoogle ScholarPubMed
Singh, NP, Despars, JA, Stansbury, DW. Effects of buspirone on anxiety levels and exercise tolerance in patients with chronic airflow obstruction and mild anxiety. Chest. 1993;103(3):800–804.CrossRefGoogle ScholarPubMed
Burns, BH, Howell, JB. Disproportionately severe breathlessness in chronic bronchitis. Q J Med. 1969;38(151):277–294.Google ScholarPubMed
Mueller, RA, Lundberg, DB, Breese, GR. The neuropharmacology of respiratory control. Pharmacol Rev. 1982;34(3):255–285.Google ScholarPubMed
Papp, , Weiss, JR, Greenberg, HE. Sertraline for chronic obstructive pulmonary disease and comorbid anxiety and mood disorders. Am J Psychiatry. 1995;152(10):1531.Google ScholarPubMed
Smoller, JW, Pollack, MH, Systrom, D. Sertraline effects on dyspnea in patients with obstructive airway disease. Psychosomatics. 1998;39(1):24–29.CrossRefGoogle Scholar
Ventresca, PG, Nichol, GM, Barnes, PJ. Inhaled furosemide inhibits cough induced by low chloride content solutions but not by capsaicin. Am Rev Respir Dis. 1990;142(1):143–146.CrossRefGoogle Scholar
Bianco, S, Pieroni, MG, Refini, RM. Protective effect of inhaled furosemide on allergen-induced early and late asthmatic reactions. N Engl J Med. 1989;321(16):1069–1073.CrossRefGoogle ScholarPubMed
Bianco, S, Vaghi, A, Robuschi, M. Prevention of exercise-induced bronchoconstriction by inhaled frusemide. Lancet. 1988;2(8605): 252–255.CrossRefGoogle ScholarPubMed
Robuschi, M, Gambaro, G, Spagnotto, S. Inhaled frusemide is highly effective in preventing ultrasonically nebulised water bronchoconstriction. Pulm Pharmacol. 1989;1(4): 187–191.CrossRefGoogle ScholarPubMed
Chung, KF, Barnes, PJ. Loop diuretics and asthma. Pulm Pharmacol. 1992;5(1):1–7.CrossRefGoogle ScholarPubMed
Ong, K-C, Kor, A-C, Chong, W-F. Effects of inhaled furosemide on exertional dyspnea in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;169(9):1028–1033.CrossRefGoogle ScholarPubMed
Ahmedzai, SH, Laude, E, Robertson, A. A double-blind, randomised, controlled phase II trial of Heliox28 gas mixture in lung cancer patients with dyspnoea on exertion. Br J Cancer. 2004;90(2):366–371.CrossRefGoogle ScholarPubMed
Corner, J, O';Driscoll, M. Development of a breathlessness assessment guide for use in palliative care. Palliative Med. 1999;13(5):375–384.CrossRefGoogle ScholarPubMed
O';Neill, S, McCarthy, DS. Postural relief of dyspnoea in severe chronic airflow limitation: relationship to respiratory muscle strength. Thorax. 1983;38(8):595–600.CrossRefGoogle Scholar
Sharp, JT, Drutz, WS, Moisan, T. Postural relief of dyspnea in severe chronic obstructive pulmonary disease. Am Rev Respir Dis. 1980;122(2):201–211.Google ScholarPubMed
Barach, AL.Chronic obstructive lung disease: postural relief of dyspnea. Arch Phys Med Rehab. 1974;55(11):494–504.Google ScholarPubMed
Barach, AL, Beck, GJ. The ventilatory effects of the head-down position in pulmonary emphysema. Am J Med. 1954;16(1):55–60.CrossRefGoogle ScholarPubMed
Tiep, BL, Burns, M, Kao, D. Pursed lips breathing training using ear oximetry. Chest. 1986;90(2):218–221.CrossRefGoogle ScholarPubMed
Madge, S, Edmond, G. End-stage management of respiratory disease. In: Esmond, G, ed. Respiratory Nursing. London: Bailliere Tindall; 2001: 229–240.Google Scholar
Smith, EL, Hann, DM, Ahles, TA. Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer. J Pain Symptom Manage. 2001;21(4):323–329.CrossRefGoogle ScholarPubMed
Booth, S, Silvester, S, Todd, C. Breathlessness in cancer and chronic obstructive pulmonary disease: using a qualitative approach to describe the experience of patients and carers. Palliative Support Care. 2003;1(4):337–344.CrossRefGoogle ScholarPubMed
Seamark, DA, Blake, SD, Seamark, CJ. Living with severe chronic obstructive pulmonary disease (COPD): perceptions of patients and their carers. An interpretative phenomenological analysis. Palliative Med. 2004;18(7):619–625.CrossRefGoogle ScholarPubMed
Saunders, C. Care of patients suffering from terminal illness at St. Joseph's Hospice, Hackney, London. Nursing Mirror. 1964;14:vii–x.Google Scholar
Abernethy, AP, Wheeler, JL. Total dyspnoea. Curr Opin Support Palliative Care. 2008;2(2):110–113.CrossRefGoogle ScholarPubMed
Zigmond, AS, Snaith, RP, Zigmond, AS. The Hospital Anxiety and Depression Scale. Acta Psych Scand. 1983;67(6):361–370.CrossRefGoogle ScholarPubMed
NCCN Clinical Practice Guidelines in Oncology: Distress Management. Fort Washington, PA: National Comprehensive Cancer Network; 2007.
Peterman, AH, Fitchett, G, Brady, MJ. Measuring spiritual well-being in people with cancer: the functional assessment of chronic illness therapy – Spiritual Well-being Scale (FACIT-Sp). Ann Behav Med. 2002;24(1):49–58.CrossRefGoogle Scholar
,VNAA Chronic Care Clearinghouse home page. Available at: http://www.chronicconditions.org/.
,Pulmonary Rehabilitation Toolkit home page. Available at: http://www.pulmonaryrehab.com.au/.
Bruera, E, MacEachern, T, Ripamonti, C. Subcutaneous morphine for dyspnea in cancer patients. Ann Intern Med. 1993;119(9):906–907.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure coreplatform@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×