In this chapter, we discuss the questions of where and when Near Eastern plant domestication occurred: Did it transpire in a single, defined area, or perhaps it took place in different areas across the entire Fertile Crescent? Was each crop domesticated separately, or perhaps several crops were domesticated together as a harmonious agricultural package, in which crops complement each other nutritionally and agronomically? Was each crop domesticated on several occasions, each in a separate location, or did each crop undergo a single domestication episode? We look into evidence for each of these questions, based on several fields of knowledge, including geobotany, archaeology, archaeobotany and genetics – some of which we touched upon in earlier chapters. Finally, we examine whether the picture that emerges through these combined lines of evidence allows us to trace the progression of the new, agriculturally based economy throughout the Near East and from there to Europe, Asia and Africa.