Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-26T19:45:40.497Z Has data issue: false hasContentIssue false

Chapter 13 - Prophylaxis for Fetal Growth Restriction: Aspirin and Low-Molecular-Weight Heparins

from Section 4 - Prophylaxis and Treatment

Published online by Cambridge University Press:  23 July 2018

Christoph Lees
Affiliation:
Imperial College London
Gerard H. A. Visser
Affiliation:
Universiteit Utrecht, The Netherlands
Kurt Hecher
Affiliation:
University Medical Centre, Hamburg
Get access

Summary

Image of the first page of this content. For PDF version, please use the ‘Save PDF’ preceeding this image.'
Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2018

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Schiff, E, Peleg, E, Goldenberg, M, Rosenthal, T, Ruppin, E, Tamarkin, M, Barkai, G, Ben-Baruch, G, Yahal, I, Blankstein, J, et al. The use of aspirin to prevent pregnancy-induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Engl J Med 1989;321:351–6.Google Scholar
Benigni, A, Gregorini, G, Frusca, T, Chiabrando, C, Ballerini, S, Valcamonico, A, Orisio, S, Piccinelli, A, Pinciroli, V, Fanelli, R, et al. Effect of low-dose aspirin on fetal and maternal generation of thromboxane by platelets in women at risk for pregnancy-induced hypertension. N Engl J Med 1989;321:357–62.Google Scholar
Quenby, S, Mountfield, S, Cartwright, JE, Whitley, GS, Vince, G. Effects of low-molecular-weight and unfractionated heparin on trophoblast function. Obstet Gynecol 2004;104:354–61.Google Scholar
Han, CS, Mulla, MJ, Brosens, JJ, Chamley, LW, Paidas, MJ, Lockwood, CJ, Abrahams, VM. Aspirin and heparin effect on basal and antiphospholipid antibody modulation of trophoblast function. Obstet Gynecol 2011;118:1021–8.CrossRefGoogle ScholarPubMed
Henderson, JT, Whitlock, EP, O’Connor, E, Senger, CA, Thompson, JH, Rowland, MG. Low-dose aspirin for prevention of morbidity and mortality from preeclampsia: A systematic evidence review for the U.S. Preventive Services Task Force. Ann Intern Med 2014;160:695703.Google Scholar
Bujold, E, Roberge, S, Lacasse, Y, Bureau, M, Audibert, F, Marcoux, S, Forest, JC, Giguere, Y. Prevention of preeclampsia and intrauterine growth restriction with aspirin started in early pregnancy: a meta-analysis. Obstet Gynecol 2010;116:402–14.CrossRefGoogle ScholarPubMed
Meher, S, Alfirevic, Z. Aspirin for pre-eclampsia: Beware of subgroup meta-analysis. Ultrasound Obstet Gynecol 2013;41:479–85.Google Scholar
Duley, L, Henderson-Smart, DJ, Meher, S, King, JF. Antiplatelet agents for preventing pre-eclampsia and its complications. Cochrane Database Syst Rev 2007, Issue 2. Art. No.: CD004659.Google Scholar
Henderson, JT, Whitlock, EP, O’Conner, E, Senger, CA, Thompson, JH, Rowland, MG. Low-Dose Aspirin for the Prevention of Morbidity and Mortality From Preeclampsia: A Systematic Evidence Review for the U.S. Preventive Services Task Force. Evidence Synthesis No. 112. AHRQ Publication No. 14-05207-EF-1. Rockville, MD: Agency for Healthcare Research and Quality; 2014.Google Scholar
Rolnik, DL, Wright, D, Poon, LC, O’Gorman, N, Syngelaki, A, de Paco Matallana, C, Akolekar, R, Cicero, S, Janga, D, Singh, M, Molina, FS, Persico, N, Jani, JC, Plasencia, W, Papaioannou, G, Tenenbaum-Gavish, K, Meiri, H, Gizurarson, S, Maclagan, K, Nicolaides, KH. Aspirin versus placebo in pregnancies at high risk for preterm preeclampsia. N Engl J Med 2017;377:613622.Google Scholar
Askie, LM, Duley, L, Henderson-Smart, DJ, Stewart, LA, Group, PC. Antiplatelet agents for prevention of pre-eclampsia: A meta-analysis of individual patient data. Lancet 2007;369:1791–8.CrossRefGoogle ScholarPubMed
Roberge, S, Nicolaides, KH, Demers, S, Villa, P, Bujold, E. Prevention of perinatal death and adverse perinatal outcome using low-dose aspirin: A meta-analysis. Ultrasound Obstet Gynecol 2013;41:491–9.CrossRefGoogle ScholarPubMed
Ayala, DE, Ucieda, R, Hermida, RC. Chronotherapy with low-dose aspirin for prevention of complications in pregnancy. Chronobiol Int 2013;30:260–79.Google Scholar
Wojtowicz, A, Undas, A, Huras, H, Musial, J, Rytlewski, K, Reron, A, Wilczak, M, Jach, R. Aspirin resistance may be associated with adverse pregnancy outcomes. Neuro Endocrinol Lett 2011;32:334–9.Google Scholar
Wallenburg, HC, Rotmans, N. Prevention of recurrent idiopathic fetal growth retardation by low-dose aspirin and dipyridamole. Am J Obstet Gynecol 1987;157:1230–5.CrossRefGoogle ScholarPubMed
CLASP: A randomised trial of low-dose aspirin for the prevention and treatment of pre-eclampsia among 9364 pregnant women. CLASP (Collaborative Low-dose Aspirin Study in Pregnancy) Collaborative Group. Lancet 1994;343:619–29.Google Scholar
McParland, P, Pearce, JM, Chamberlain, GV. Doppler ultrasound and aspirin in recognition and prevention of pregnancy-induced hypertension. Lancet 1990;335:1552–5.Google Scholar
Viinikka, L, Hartikainen-Sorri, AL, Lumme, R, Hiilesmaa, V, Ylikorkala, O. Low dose aspirin in hypertensive pregnant women: Effect on pregnancy outcome and prostacyclin-thromboxane balance in mother and newborn. BJOG 1993;100:809–15.Google Scholar
Caspi, E, Raziel, A, Sherman, D, Arieli, S, Bukovski, I, Weinraub, Z. Prevention of pregnancy-induced hypertension in twins by early administration of low-dose aspirin: A preliminary report. Am J Reprod Immunol 1994;31:1924.Google Scholar
Hermida, RC, Ayala, DE, Iglesias, M, Mojon, A, Silva, I, Ucieda, R, Fernandez, JR. Time-dependent effects of low-dose aspirin administration on blood pressure in pregnant women. Hypertension 1997;30:589–95.Google Scholar
Caritis, S, Sibai, B, Hauth, J, Lindheimer, MD, Klebanoff, M, Thom, E, Van Dorsten, P, Landon, M, Paul, R, Miodovnik, M, Meis, P, Thurnau, G. Low-dose aspirin to prevent preeclampsia in women at high risk. National Institute of Child Health and Human Development Network of Maternal-Fetal Medicine Units. N Engl J Med 1998;338:701–5.CrossRefGoogle ScholarPubMed
Vainio, M, Kujansuu, E, Iso-Mustajarvi, M, Maenpaa, J. Low dose acetylsalicylic acid in prevention of pregnancy-induced hypertension and intrauterine growth retardation in women with bilateral uterine artery notches. BJOG 2002;109:161–7.Google Scholar
Yu, CK, Papageorghiou, AT, Parra, M, Palma, Dias, R, Nicolaides, KH, Fetal Medicine Foundation Second Trimester Screening G. Randomized controlled trial using low-dose aspirin in the prevention of pre-eclampsia in women with abnormal uterine artery Doppler at 23 weeks’ gestation. Ultrasound Obstet Gynecol 2003;22:233–9.Google Scholar
Villa, PM, Kajantie, E, Raikkonen, K, Pesonen, AK, Hamalainen, E, Vainio, M, Taipale, P, Laivuori, H, Group, PS. Aspirin in the prevention of pre-eclampsia in high-risk women: A randomised placebo-controlled PREDO Trial and a meta-analysis of randomised trials. BJOG 2013;120:6474.Google Scholar
Kingdom, JC, Walker, M, Proctor, LK, Keating, S, Shah, PS, McLeod, A, Keunen, J, Windrim, RC, Dodd, JM. Unfractionated heparin for second trimester placental insufficiency: A pilot randomized trial. J Thromb Haemost 2011;9:1483–92.Google Scholar
Kupferminc, M, Rimon, E, Many, A, Maslovitz, S, Lessing, JB, Gamzu, R. Low molecular weight heparin versus no treatment in women with previous severe pregnancy complications and placental findings without thrombophilia. Blood Coagul Fibrinolysis 2011;22:123–6.Google Scholar
Duffett, L, Rodger, M. LMWH to prevent placenta-mediated pregnancy complications: An update. Br J Haematol 2014.Google Scholar
Greer, IA, Brenner, B, Gris, JC. Antithrombotic treatment for pregnancy complications: Which path for the journey to precision medicine? Br J Haematol 2014;165:585–99.Google Scholar
Dodd, JM, McLeod, A, Windrim, RC, Kingdom, J. Antithrombotic therapy for improving maternal or infant health outcomes in women considered at risk of placental dysfunction. Cochrane Database Sys Rev 2013, Issue 7. Art. No.: CD006780.Google Scholar
Rodger, MA, Carrier, M, Le Gal, G, Martinelli, I, Perna, A, Rey, E, De Vries, JI, Gris, JC, Low-Molecular-Weight Heparin for Placenta-Mediated Pregnancy Complications Study G. Meta-analysis of low-molecular-weight heparin to prevent recurrent placenta-mediated pregnancy complications. Blood 2014;123:822–8.Google Scholar
Rodger, MA, Hague, WM, Kingdom, J, Kahn, SR, Karovitch, A, Sermer, M, Clement, AM, Coat, S, Chan, WS, Said, J, Rey, E, Robinson, S, Khurana, R, Demers, C, Kovacs, MJ, Solymoss, S, Hinshaw, K, Dwyer, J, Smith, G, McDonald, S, Newstead-Angel, J, McLeod, A, Khandelwal, M, Silver, RM, Le Gal, G, Greer, IA, Keely, E, Rosene-Montella, K, Walker, M, Wells, PS, Investigators, T. Antepartum dalteparin versus no antepartum dalteparin for the prevention of pregnancy complications in pregnant women with thrombophilia (TIPPS): a multinational open-label randomised trial. Lancet 2014;384:1673–83.CrossRefGoogle Scholar
Mello, G, Parretti, E, Fatini, C, Riviello, C, Gensini, F, Marchionni, M, Scarselli, GF, Gensini, GF, Abbate, R. Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women. Hypertension 2005;45:8691.Google Scholar
Rey, E, Garneau, P, David, M, Gauthier, R, Leduc, L, Michon, N, Morin, F, Demers, C, Kahn, SR, Magee, LA, Rodger, M. Dalteparin for the prevention of recurrence of placental-mediated complications of pregnancy in women without thrombophilia: A pilot randomized controlled trial. J Thromb Haemost 2009;7:5864.Google Scholar
Gris, JC, Chauleur, C, Molinari, N, Mares, P, Fabbro-Peray, P, Quere, I, Lefrant, JY, Haddad, B, Dauzat, M. Addition of enoxaparin to aspirin for the secondary prevention of placental vascular complications in women with severe pre-eclampsia. The pilot randomised controlled NOH-PE trial. Thromb Haemost 2011;106:1053–61.Google Scholar
De Vries, JI, Van Pampus, MG, Hague, WM, Bezemer, PD, Joosten, JH, Investigators, F. Low-molecular-weight heparin added to aspirin in the prevention of recurrent early-onset pre-eclampsia in women with inheritable thrombophilia: The FRUIT-RCT. J Thromb Haemost 2012;10:6472.CrossRefGoogle ScholarPubMed
Martinelli, I, Ruggenenti, P, Cetin, I, Pardi, G, Perna, A, Vergani, P, Acaia, B, Facchinetti, F, La Sala, GB, Bozzo, M, Rampello, S, Marozio, L, Diadei, O, Gherardi, G, Carminati, S, Remuzzi, G, Mannucci, PM, Group, HS. Heparin in pregnant women with previous placenta-mediated pregnancy complications: A prospective, randomized, multicenter, controlled clinical trial. Blood 2012;119:3269–75.Google Scholar
Greer, IA, Nelson-Piercy, C. Low-molecular-weight heparins for thromboprophylaxis and treatment of venous thromboembolism in pregnancy: A systematic review of safety and efficacy. Blood 2005;106:401–7.CrossRefGoogle ScholarPubMed
Casele, H, Haney, EI, James, A, Rosene-Montella, K, Carson, M. Bone density changes in women who receive thromboprophylaxis in pregnancy. Am J Obstet Gynecol 2006;195:1109–13.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure no-reply@cambridge.org is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×