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Chapter 26 - Non-Neoplastic Accumulation of Histiocytes

from Section VI - Histiocytic Disorders and Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Jennifer Picarsic
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

The ontogeny of native Langerhans cells (LCs) in the epidermis has been debated over the past decade, with most agreeing that such LCs are now best classified as specialized resident-tissue macrophages derived from the embryonic yolk sac that have a self-renewal capacity in the steady state, along with migratory dendritic cell (DC)–like properties (albeit with much slower migration as compared to conventional or classic DCs [cDCs]) (1). The diversity of the epidermal pool of resident and inflammatory macrophages and DCs may be greater than previously realized – with LCs, monocyte-derived LC-like cells, and inflammatory dendritic epidermal cells (IDECs) all acting as human antigen-presenting cells (1).

Type
Chapter
Information
Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 312 - 319
Publisher: Cambridge University Press
Print publication year: 2024

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References

Otsuka, M, Egawa, G, Kabashima, K. Uncovering the mysteries of Langerhans Cells, inflammatory dendritic epidermal cells, and monocyte-derived Langerhans cell-like cells in the epidermis. Front Immunol. 2018;9:1768.Google Scholar
Collin, M, Bigley, V. Human dendritic cell subsets: an update. Immunology. 2018;154(1):3–20.Google Scholar
McGovern, N, Shin, A, Low, G, Low, D, Duan, K, Yao, LJ, et al. Human fetal dendritic cells promote prenatal T-cell immune suppression through arginase-2. Nature. 2017;546(7660):662–6.Google Scholar
McGovern, N, Chan, JKY, Ginhoux, F. Dendritic cells in humans – from fetus to adult. Int Immunol. 2014;27(2):65–72.Google Scholar
Garces, S, Yin, CC, Miranda, RN, Patel, KP, Li, S, Xu, J, et al. Clinical, histopathologic, and immunoarchitectural features of dermatopathic lymphadenopathy: an update. Mod Pathol. 2020;33(6):1104–21.Google Scholar
Facchetti, F, Blanzuoli, L, Ungari, M, Alebardi, O, Vermi, W. Lymph node pathology in primary combined immunodeficiency diseases. Springer Semin Immunopathol. 1998;19(4):459–78.Google Scholar
Picarsic, J, Jaffe, R. Nosology and pathology of Langerhans cell histiocytosis. Hematol Oncol Clin North Am. 2015;29(5):799–823.CrossRefGoogle ScholarPubMed
Shanmugam, V, Craig, JW, Hornick, JL, Morgan, EA, Pinkus, GS, Pozdnyakova, O. Cyclin D1 is expressed in neoplastic cells of Langerhans cell histiocytosis but not reactive Langerhans cell proliferations. Am J Surg Pathol. 2017;41(10):1390–6.Google Scholar
Cruz, PD, East, C, Bergstresser, PR. Dermal, subcutaneous, and tendon xanthomas: Diagnostic markers for specific lipoprotein disorders. J Am Acad Dermatol. 1988;19(1, Part 1):95–111.CrossRefGoogle ScholarPubMed
Lynch, JM, Barrett, TL. Collagenolytic (necrobiotic) granulomas: part II – the “red” granulomas. J Cutan Pathol. 2004;31(6):409–18.Google Scholar
Doffinger, R, Patel, S, Kumararatne, DS. Human immunodeficiencies that predispose to intracellular bacterial infections. Curr Opin Rheumatol. 2005;17(4):440–6.Google Scholar
Liew, W-K, Thoon, K-C, Chong, C-Y, Tan, NWH, Cheng, D-T, Chan, BSW, et al. Juvenile-onset immunodeficiency secondary to anti-interferon-gamma autoantibodies. J Clin Immunol. 2019;39(5):512–8.Google Scholar
Landing, BH, Shirkey, HS. A syndrome of recurrent infection and infiltration of viscera by pigmented lipid histiocytes. Pediatrics. 1957;20(3):431–8.Google Scholar
Yousef, GM, Naghibi, B. Malakoplakia outside the urinary tract. Arch Pathol Lab Med. 2007;131(2):297–300.Google Scholar
Dogan, S, Barnes, L, Cruz-Vetrano, WP. Crystal-storing histiocytosis: report of a case, review of the literature (80 cases) and a proposed classification. Head Neck Pathol. 2012;6(1):111–20.Google Scholar
Lewis, JT, Candelora, JN, Hogan, RB, Briggs, FR, Abraham, SC. Crystal-storing histiocytosis due to massive accumulation of charcot-leyden crystals: a unique association producing colonic polyposis in a 78-year-old woman with eosinophilic colitis. Am J Surg Pathol. 2007;31(3):481–5.Google Scholar
Parizhskaya, M, Youssef, NN, Di Lorenzo, C, Goyal, RK. Clofazimine enteropathy in a pediatric bone marrow transplant recipient. J Pediatrics. 2001;138(4):574–6.Google Scholar
Turk, JL. The mononuclear phagocyte system in granulomas. Br J Dermatol. 1985;113(s28):49–54.Google Scholar
Uzzan, M, Ko, HM, Mehandru, S, Cunningham-Rundles, C. Gastrointestinal disorders associated with common variable immune deficiency (CVID) and chronic granulomatous disease (CGD). Curr Gastroenterol Rep. 2016;18(4):17.Google Scholar
Morimoto, Y, Routes, JM. Granulomatous disease in common variable immunodeficiency. Curr Allergy Asthma Rep. 2005;5(5):370–5.Google Scholar
Leung, J, Sullivan, KE, Perelygina, L, Icenogle, JP, Fuleihan, RL, Lanzieri, TM. Prevalence of granulomas in patients with primary immunodeficiency disorders, United States: data from national health care claims and the US Immunodeficiency Network Registry. J Clin Immunol. 2018;38(6):717–26.CrossRefGoogle ScholarPubMed
Nanda, A, Al-Herz, W, Al-Sabah, H, Al-Ajmi, H. Noninfectious cutaneous granulomas in primary immunodeficiency disorders: report from a national registry. Am J Dermatopathol. 2014;36(10):832–7.Google Scholar
Schaffer, JV, Chandra, P, Keegan, BR, Heller, P, Shin, HT. Widespread granulomatous dermatitis of infancy: an early sign of Blau syndrome. Arch Dermatol. 2007;143(3):386–91.Google Scholar
Ferreira, CR, Gahl, WA. Lysosomal storage diseases. Transl Sci Rare Dis. 2017;2(1–2):1–71.Google Scholar
Pileri, S, Falini, B, Delsol, G, Stein, H, Baglioni, P, Poggi, S, et al. Lymphohistiocytic T-cell lymphoma (anaplastic large cell lymphoma CD30+/Ki-1+ with a high content of reactive histiocytes). Histopathology. 1990;16(4):383–91.Google Scholar
Berklite, L, Ranganathan, S, John, I, Picarsic, J, Santoro, L, Alaggio, R. Fibrous histiocytoma/dermatofibroma in children: the same as adults? Human Pathology. 2020;99:107–15.Google Scholar
Martinez, AP, Fritchie, KJ, Weiss, SW, Agaimy, A, Haller, F, Huang, H-Y, et al. Histiocyte-rich rhabdomyoblastic tumor: rhabdomyosarcoma, rhabdomyoma, or rhabdomyoblastic tumor of uncertain malignant potential? A histologically distinctive rhabdomyoblastic tumor in search of a place in the classification of skeletal muscle neoplasms. Mod Pathol. 2019;32(3):446–57.Google Scholar

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