Published online by Cambridge University Press: 27 July 2023
The primitive gut tube arises as a consequence of folding of the embryo, a process which is complete by the end of the fourth week after fertilisation. The primitive gut tube is formed as an endoderm lined tube with blind diverticula at the cranial and caudal extremities. These blind-ending diverticula are bounded from the exterior by the buccopharyngeal and cloacal membranes at the cranial and caudal ends, respectively. At its formation, and critical to development of the gastrointestinal (GI) tract, the primitive gut tube maintains continuity with the yolk sac from which it is formed via the vitelline duct at the umbilicus.
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