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  • Print publication year: 2011
  • Online publication date: July 2011

12 - Memory development and learning

Summary

Introduction

Distinct cognitive profiles among individuals with mental retardation (MR) of different etiologies have recently been documented. Studies from different laboratories, for example, have demonstrated a complex neuropsychological profile in people with Down syndrome (DS), with atypical development in the cognitive and linguistic domains (for a review see Vicari et al., 2004; Vicari, 2006). However, a quite different pattern is often reported in other syndromes such as Williams syndrome (WS). This is another genetic condition, less frequent but equally characterized by MR and typified by a number of severe medical anomalies, such as facial dysmorphology and abnormalities of the cardiovascular system (Bellugi et al., 1999). Differently from DS, WS children often show marked impairment in certain spatial abilities (especially praxic–constructive) and relative preservation of both productive and receptive language, at least concerning the phonological elements (Vicari et al., 2004).

Within the neuropsychological approach to MR, the study of memory and learning is particularly relevant. In fact, altered development of the memory function can seriously interfere with adequate maturation of general intellectual abilities, and thus with the possibility of learning and modifying behavior on the basis of experience.

This chapter is dedicated to reviewing the neuropsychological literature and recent experimental studies on memory and learning development in people with DS, reporting their memory capacities and deficits. Consistent with a neuropsychological approach, distinct memory profiles can be traced to the characteristics of the DS brain development and architecture.

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References
Ashburner, J. & Friston, K. J. (2000). Voxel-based morphometry: the methods. NeuroImage, 11, 805–821.
Atkinson, R. C. & Shiffrin, R. M. (1971). The control of short-term memory. Scientific American, 225, 82–90.
Baddeley, A. D. (1986). Working Memory. London: Oxford University Press.
Baddeley, A. D. & Hitch, G. (1974). Working memory. In Bower, G. (ed.), The Psychology of Learning and Motivation, Vol. 8, pp. 47–90. New York: Holt, Rinehart & Winston.
Bellugi, U., Mills, D., Jerningan, T., Hickok, G., Galaburda, A. (1999). Linking cognition, brain structure, and brain function in Williams syndrome. In Tager-Flusberg, H. ed.), Neurodevelopmental Disorders, pp. 111–136. Cambridge: MIT Press.
Carlesimo, G. A., Marotta, L., Vicari, S. (1997). Long-term memory in mental retardation: evidence for a specific impairment in subjects with Down's syndrome. Neuropsychologia, 35, 71–79.
Chapman, R. S. (1995). Language development in children and adolescents with Down syndrome. In Fletcher, P. & MacWinney, B. (eds.), The Handbook of Child Language, pp. 641–663. Oxford: Blackwell.
Della Sala, S. & Logie, R. H. (2002). Neuropsychological impairments of visual and spatial working memory. In Baddeley, A., Wilson, B., Kopelman, M. (eds.), Handbook of Memory Disorders, pp. 271 –292. Chichester: Wiley.
Fabbro, F., Alberti, A., Gagliardi, C., Borgatti, R. (2002). Differences in native and foreign language repetition task between subjects with Williams and Down syndromes. Journal of Neurolinguistics, 15, 1–10.
Fowler, A. E. (1995). Linguistic variability in persons with Down syndrome. In Nadel, L. & Rosenthal, D. (eds.), Down Syndrome: Living and Learning in the Community, pp. 121–131. New York: Wiley-Liss.
Gathercole, S. E. & Baddeley, A. D. (1993). Working Memory and Language. Hove: Erlbaum.
Good, C. D., Johnsrude, I., Ashburner, J., et al. (2001). A voxel-based morphometric study of ageing in 465 normal adult human brains. NeuroImage, 14, 21–36.
Hulme, C. & Mackenzie, S. (1992). Working Memory and Severe Learning Difficulties. Hove: Erlbaum.
Ikeda, M. & Arai, Y. (2002). Longitudinal changes in brain CT scans and development of dementia in Down's syndrome. European Neurology, 47, 205–208.
Jarrold, C., Baddeley, A. D., Hewes, A. K. (1999). Genetically dissociated components of working memory: evidence from Down and Williams syndrome. Neuropsychologia, 37, 637–651.
Jarrold, C., Baddeley, A. D., Hewes, A. K. (2000). Verbal short-term memory deficits in Down syndrome: a consequence of problems in rehearsal? Journal of Child Psychology and Psychiatry, 40(2), 233–244.
Kanno, K. & Ikeda, Y. (2002). Word-length effect in verbal short-term memory in individuals with Down's syndrome. Journal of Intellectual Disability Research, 46, 613–618.
Kesslak, J. P., Nagata, B. S., Lott, I., Nalcioglu, O. (1994). MRI analysis of age-related changes in the brains of individuals with DS. Neurology, 44, 1039–1045.
Krasuski, J. S., Alexander, G. E., Horowitz, B., Rapoport, S. I., Shapiro, M. B. (2002). Relation of medial temporal volumes to age and memory function in non-demented adults with Down's syndrome: implications for the prodromal phase of Alzheimer's disease. American Journal of Psychiatry, 159, 74–81.
Laws, G. (2002). Working memory in children and adolescents with Down syndrome: evidence from a colour memory experiment. Journal of Child Psychology and Psychiatry, 43, 353–364.
Laws, G. (2004). Contributions of phonological memory, language comprehension and hearing to the expressive language of adolescents and young adults with Down syndrome. Journal of Child Psychology and Psychiatry, 45, 1–11.
Laws, G. & Gunn, D. (2003). Phonological memory as a predictor of language comprehension in Down syndrome: a five-year follow-up study. Journal of Child Psychology and Psychiatry, 44, 1–11.
Logie, R. H. (1995). Visuo-spatial Working Memory. Hove: Erlbaum.
Menghini, D., Costanzo, F., & Vicari, S. (in press). Relationship between brain and cognitive processes in Down syndrome. Behavior Genetics. DOI 10.1007/s10519-011-9448-3.
Mishkin, M. & Ungerleider, L. G. (1982). Contribution of striate inputs to the visuospatial functions of parieto-preoccipital cortex in monkeys. Behavioral Brain Research, 6, 57–77.
Molinari, M., Leggio, M. G., Solida, A., et al. (1997). Cerebellum and procedural learning: evidence from focal cerebellar lesions. Brain, 120, 1753–1762.
Moscovitch, C., Kapur, S., Kohler, S., Houle, S. (1995). Distinct neural correlates of visual long-term memory for spatial location and object identity: a positron emission tomography study in humans. Proceedings of the National Academy of Science of the United States of America, 92, 3721–3725.
Nadel, L. (1999). Learning and memory in Down syndrome. In Rondal, J. A., Perera, J., Nadel, L. (eds.), Down Syndrome: A Review of Current Knowledge, pp. 133–142. London: Whurr.
Pennington, B. F., Moon, J., Edgin, J., Stedron, J., Nadel, L. (2003). The neuropsychology of Down syndrome: evidence for hippocampal dysfunction. Child Development, 74, 75–93.
Pinter, J. D., Eliez, S., Schmitt, J. E., Capone, G. T., Reiss, A. L. (2001). Neuroanatomy of Down's syndrome: a high-resolution MRI study. American Journal of Psychiatry, 158, 1659–1665.
Squire, L. R. (1987). Memory and Brain. Oxford: Oxford University Press.
Teipel, S. J., Alexander, G. E., Schapiro, M. B., et al. (2004). Age-related cortical grey matter reductions in nondemented Down's syndrome adults determined by MRI with voxel-based morphometry. Brain, 127, 811–824.
Graaf, F. H., Jong, B. M., Maguire, R. P., Meiners, L. C., Leenders, K. L. (2004). Cerebral activation related to skills practice in a double serial reaction time task: striatal involvement in random-order sequence learning. Brain Research and Cognitive Brain Research, 20, 120–131.
Vicari, S. (2006). Motor development and neuropsychological patterns in persons with Down syndrome. Behavior Genetics, 36, 355–364.
Vicari, S., Bates, E., Caselli, M. C., et al. (2004). Neuropsychological profile of Italians with Williams syndrome: an example of a dissociation between language and cognition?Journal of the International Neuropsychological Society, 10, 862–876.
Vicari, S., Bellucci, S., Carlesimo, G. A. (2000). Implicit and explicit memory: a functional dissociation in persons with Down syndrome. Neuropsychologia, 38, 240–251.
Vicari, S., Bellucci, S., Carlesimo, G. A. (2001). Procedural learning deficit in children with Williams syndrome. Neuropsychologia, 39, 665–677.
Vicari, S., Bellucci, S., Carlesimo, G. A. (2003). Visual and spatial working memory dissociation: evidence from a genetic syndrome. Developmental Medicine and Child Neurology, 45, 269–273.
Vicari, S., Bellucci, S., Carlesimo, G. A. (2005). Visual and spatial long-term memory: differential pattern of impairments in Williams and Down syndromes. Developmental Medicine and Child Neurology, 47, 305–311.
Vicari, S., Bellucci, S., Carlesimo, G. A. (2006). Evidence from two genetic syndromes for the independence of spatial and visual working memory. Developmental Medicine and Child Neurology, 48, 126–131.
Vicari, S. & Carlesimo, G. A. (2002). Children with intellectual disabilities. In Baddeley, A., Wilson, B., Kopelman, M. (eds.), Handbook of Memory Disorders, pp. 501–518. Chichester: Wiley.
Vicari, S. & Carlesimo, G. A. (2006). Short-term memory deficits are not uniform in Down and Williams syndromes. Neuropsychological review, 16, 87–94.
Vicari, S., Carlesimo, G. A., Caltagirone, C. (1995). Short-term memory in persons with intellectual disabilities and Down syndrome. Journal of Intellectual Disability Research, 39, 532–537.
Vicari, S., Verucci, L., Carlesimo, G. A. (2007). Implicit memory is independent from IQ and age but not from etiology: evidence from Down and Williams syndromes. Journal of Intellectual Disability Research, 51, 932–941.
Wang, P. P. & Bellugi, U. (1994). Evidence from two genetic syndromes for dissociation between verbal and visual-spatial short-term memory. Journal of Clinical Experimental Neuropsychology, 16, 317–322.
Wisniewski, K. E. (1990). Down syndrome children often have brain with maturation delay, retardation of growth, and cortical digenesis. American Journal of Medical Genetics, 7, 274–281.
White, N. S., Alkire, M. T., Haier, R. J. (2003). A voxel-based morphometric study of nondemented adults with Down syndrome. NeuroImage, 20, 393–403.